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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SOX18
Z-value: 0.66
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Transcription factors associated with SOX18
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX18 | hg38_v1_chr20_-_64049631_64049646 | 0.01 | 8.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX18
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.9 | GO:0043401 | steroid hormone mediated signaling pathway(GO:0043401) |
| 0.2 | 17.0 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 2.2 | 13.2 | GO:0098707 | ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707) |
| 0.4 | 10.0 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
| 0.9 | 9.4 | GO:0090292 | nuclear matrix anchoring at nuclear membrane(GO:0090292) |
| 0.0 | 8.2 | GO:0010038 | response to metal ion(GO:0010038) |
| 0.8 | 7.2 | GO:0060125 | negative regulation of growth hormone secretion(GO:0060125) |
| 0.3 | 6.9 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 1.6 | 6.5 | GO:0006542 | glutamine biosynthetic process(GO:0006542) |
| 0.1 | 6.2 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 22.6 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 2.4 | 14.1 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.3 | 10.0 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.7 | 9.4 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 8.3 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.3 | 6.9 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.2 | 6.5 | GO:0097386 | glial cell projection(GO:0097386) |
| 0.0 | 5.2 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 4.5 | GO:0044306 | neuron projection terminus(GO:0044306) |
| 0.3 | 4.0 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.1 | GO:0005496 | steroid binding(GO:0005496) |
| 0.2 | 15.4 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 1.0 | 13.2 | GO:0008199 | iron ion transmembrane transporter activity(GO:0005381) ferric iron binding(GO:0008199) |
| 0.1 | 13.2 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 11.7 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.1 | 10.0 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.3 | 9.5 | GO:0005521 | lamin binding(GO:0005521) |
| 0.2 | 7.2 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 1.6 | 6.5 | GO:0004356 | glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880) |
| 0.6 | 6.2 | GO:0004064 | arylesterase activity(GO:0004064) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 11.9 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.2 | 10.1 | PID ATR PATHWAY | ATR signaling pathway |
| 0.2 | 7.2 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.0 | 6.5 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 5.9 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.1 | 4.6 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 3.8 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 3.6 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 3.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 3.3 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 12.1 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 0.1 | 10.4 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.2 | 9.4 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 7.9 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.2 | 6.5 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.4 | 6.2 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.1 | 4.0 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.1 | 3.6 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 3.6 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.2 | 3.5 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |