Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for SOX3_SOX2
Z-value: 2.26
Motif logo
Transcription factors associated with SOX3_SOX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX2 | hg38_v1_chr3_+_181711915_181711934 | 0.33 | 8.0e-07 | Click! |
| SOX3 | hg38_v1_chrX_-_140505058_140505076 | 0.12 | 8.9e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX3_SOX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.9 | 143.1 | GO:0070494 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 0.8 | 133.6 | GO:0030705 | cytoskeleton-dependent intracellular transport(GO:0030705) |
| 25.2 | 125.8 | GO:1904209 | regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
| 3.3 | 92.6 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 6.0 | 83.5 | GO:0030050 | vesicle transport along actin filament(GO:0030050) |
| 0.5 | 81.3 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 3.0 | 76.9 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 4.2 | 70.9 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 9.2 | 55.4 | GO:0051581 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 4.3 | 55.4 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 405.2 | GO:0005874 | microtubule(GO:0005874) |
| 0.7 | 191.4 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 1.0 | 177.1 | GO:0030426 | growth cone(GO:0030426) |
| 0.8 | 162.6 | GO:0043209 | myelin sheath(GO:0043209) |
| 23.6 | 141.6 | GO:0033269 | internode region of axon(GO:0033269) |
| 1.6 | 121.3 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.7 | 119.3 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 1.0 | 103.5 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.5 | 103.5 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 4.5 | 72.5 | GO:0097512 | cardiac myofibril(GO:0097512) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 249.8 | GO:0015631 | tubulin binding(GO:0015631) |
| 19.2 | 230.4 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 1.3 | 221.0 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.3 | 202.3 | GO:0005509 | calcium ion binding(GO:0005509) |
| 2.6 | 89.8 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 2.6 | 70.5 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.4 | 66.4 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.2 | 65.8 | GO:0003779 | actin binding(GO:0003779) |
| 5.0 | 64.5 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 2.2 | 64.5 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.7 | 153.9 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 1.5 | 119.1 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.9 | 54.2 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.8 | 51.1 | PID ATR PATHWAY | ATR signaling pathway |
| 1.5 | 44.0 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.6 | 43.5 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.8 | 39.2 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.8 | 32.3 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 1.1 | 30.7 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.6 | 30.0 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.6 | 162.7 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 4.5 | 124.6 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 1.7 | 90.7 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 1.5 | 80.0 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 1.3 | 66.9 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 3.8 | 45.2 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.8 | 33.7 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.8 | 33.0 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 1.4 | 27.1 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.6 | 26.0 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |