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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SOX4
Z-value: 0.67
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Transcription factors associated with SOX4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX4 | hg38_v1_chr6_+_21593742_21593757 | -0.07 | 3.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 21.1 | GO:0033617 | mitochondrial respiratory chain complex IV assembly(GO:0033617) |
| 4.4 | 17.8 | GO:0031117 | positive regulation of microtubule depolymerization(GO:0031117) |
| 0.2 | 14.0 | GO:0006826 | iron ion transport(GO:0006826) |
| 0.8 | 11.6 | GO:0030050 | vesicle transport along actin filament(GO:0030050) |
| 0.5 | 11.3 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.1 | 10.8 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 1.3 | 10.1 | GO:1903026 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) negative regulation of interleukin-8 secretion(GO:2000483) |
| 2.5 | 10.0 | GO:0072011 | diapedesis(GO:0050904) glomerular endothelium development(GO:0072011) |
| 0.2 | 9.9 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 1.0 | 9.3 | GO:0001661 | conditioned taste aversion(GO:0001661) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 28.3 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 23.6 | GO:0031966 | mitochondrial membrane(GO:0031966) |
| 0.1 | 14.3 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.4 | 13.1 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 11.9 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 1.1 | 11.7 | GO:0098651 | basement membrane collagen trimer(GO:0098651) |
| 1.4 | 11.3 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 0.1 | 10.1 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 1.2 | 9.3 | GO:0035976 | AP1 complex(GO:0035976) |
| 1.5 | 8.9 | GO:0033269 | internode region of axon(GO:0033269) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 21.7 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.2 | 17.8 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.2 | 11.6 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.2 | 10.1 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.2 | 9.9 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.1 | 9.3 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 2.9 | 8.6 | GO:0030350 | iron-responsive element binding(GO:0030350) |
| 0.1 | 6.6 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.9 | 6.3 | GO:0030023 | extracellular matrix constituent conferring elasticity(GO:0030023) |
| 0.1 | 6.1 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 12.4 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.3 | 10.9 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.1 | 10.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 9.8 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 8.4 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 8.1 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 6.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 5.6 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 5.5 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.1 | 5.4 | PID ATR PATHWAY | ATR signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.2 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 10.8 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.6 | 9.8 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.3 | 9.3 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.2 | 6.6 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.3 | 4.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 4.7 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 4.3 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.2 | 4.2 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.1 | 4.2 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |