ISMARA results: SOX5

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SOX5

Z-value: 0.86

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Transcription factors associated with SOX5

Gene Symbol	Gene ID	Gene Info
SOX5 Ensembl NCBI GeneCards UniProt	ENSG00000134532.19	SOX5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SOX5	hg38_v1_chr12_-_23584600_23584613, hg38_v1_chr12_-_23951020_23951037	0.42	6.3e-11	Click!

Activity profile of SOX5 motif

Sorted Z-values of SOX5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX5

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Promoter	Score	Transcript	Gene	Gene Info
chr17_-_10549694 Show fit	11.73	ENST00000622564.4	MYH2 Ensembl NCBI GeneCards UniProt Show fit	myosin heavy chain 2
chr7_-_112206380 Show fit	11.17	ENST00000437633.6 ENST00000428084.6	DOCK4 Ensembl NCBI GeneCards UniProt Show fit	dedicator of cytokinesis 4
chr18_+_24014733 Show fit	10.14	ENST00000317571.8	TTC39C Ensembl NCBI GeneCards UniProt Show fit	tetratricopeptide repeat domain 39C
chr12_-_6124662 Show fit	9.87	ENST00000261405.10	VWF Ensembl NCBI GeneCards UniProt Show fit	von Willebrand factor
chr14_-_23435652 Show fit	9.67	ENST00000355349.4	MYH7 Ensembl NCBI GeneCards UniProt Show fit	myosin heavy chain 7
chr12_-_16606102 Show fit	9.22	ENST00000537304.6	LMO3 Ensembl NCBI GeneCards UniProt Show fit	LIM domain only 3
chr17_-_10549612 Show fit	9.14	ENST00000532183.6 ENST00000397183.6 ENST00000420805.1	MYH2 Ensembl NCBI GeneCards UniProt Show fit	myosin heavy chain 2
chr12_-_16605939 Show fit	9.02	ENST00000541295.5 ENST00000535535.5	LMO3 Ensembl NCBI GeneCards UniProt Show fit	LIM domain only 3
chr1_-_182391363 Show fit	8.42	ENST00000417584.6	GLUL Ensembl NCBI GeneCards UniProt Show fit	glutamate-ammonia ligase
chr17_-_10549652 Show fit	8.18	ENST00000245503.10	MYH2 Ensembl NCBI GeneCards UniProt Show fit	myosin heavy chain 2

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	29.0	GO:0001778	plasma membrane repair(GO:0001778)
0.1	18.6	GO:0043401	steroid hormone mediated signaling pathway(GO:0043401)
2.6	18.2	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.2	17.5	GO:0043268	positive regulation of potassium ion transport(GO:0043268)
0.8	14.3	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
1.2	13.2	GO:0098735	positive regulation of the force of heart contraction(GO:0098735)
1.0	11.9	GO:0048251	elastic fiber assembly(GO:0048251)
0.4	11.8	GO:0014850	response to muscle activity(GO:0014850)
2.2	11.2	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
2.1	10.6	GO:1904073	regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)

Showing 1 to 10 of 136 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.8	29.0	GO:0005826	actomyosin contractile ring(GO:0005826)
0.5	23.3	GO:0016460	myosin II complex(GO:0016460)
0.1	18.8	GO:0031901	early endosome membrane(GO:0031901)
0.1	15.6	GO:0031225	anchored component of membrane(GO:0031225)
0.6	14.7	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.8	13.2	GO:0097512	cardiac myofibril(GO:0097512)
1.3	11.9	GO:0071953	elastic fiber(GO:0071953)
0.3	11.2	GO:0032420	stereocilium(GO:0032420)
0.3	10.1	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
1.2	9.3	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)

Showing 1 to 10 of 59 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	38.1	GO:0000146	microfilament motor activity(GO:0000146)
0.4	28.8	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.2	27.1	GO:0003707	steroid hormone receptor activity(GO:0003707)
0.4	20.8	GO:0030507	spectrin binding(GO:0030507)
0.1	16.2	GO:0044325	ion channel binding(GO:0044325)
0.7	15.1	GO:0032036	myosin heavy chain binding(GO:0032036)
0.2	12.7	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.1	12.2	GO:0005178	integrin binding(GO:0005178)
0.0	11.9	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1	11.2	GO:0048365	Rac GTPase binding(GO:0048365)

Showing 1 to 10 of 87 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	43.8	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.7	38.4	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.2	24.1	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
0.3	13.3	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.8	13.2	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.2	11.4	PID IGF1 PATHWAY	IGF1 pathway
0.1	10.7	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.2	9.8	PID FGF PATHWAY	FGF signaling pathway
0.1	9.3	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.1	9.2	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms

Showing 1 to 10 of 38 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	19.9	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.2	12.7	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.4	12.6	REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.6	9.9	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.1	9.8	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2	9.1	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.1	9.1	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.1	9.0	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.3	8.4	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.2	8.2	REACTOME MUSCLE CONTRACTION	Genes involved in Muscle contraction

Showing 1 to 10 of 33 entries

Results for SOX5

Z-value: 0.86

Motif logo

Transcription factors associated with SOX5

Activity-expression correlation:

Activity profile of SOX5 motif

Sorted Z-values of SOX5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX5

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: