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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SOX6
Z-value: 0.85
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Transcription factors associated with SOX6
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX6
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_+_6226136 Show fit | 14.96 |
ENST00000676764.1
ENST00000646407.1 |
CD9 molecule |
|
| chr6_-_106974721 Show fit | 13.26 |
ENST00000606017.2
ENST00000620405.1 |
CD24 molecule |
|
| chr5_+_102808057 Show fit | 13.21 |
ENST00000684043.1
ENST00000682407.1 |
peptidylglycine alpha-amidating monooxygenase |
|
| chr16_+_3018390 Show fit | 12.47 |
ENST00000573001.5
|
TNF receptor superfamily member 12A |
|
| chr7_+_134779663 Show fit | 12.26 |
ENST00000361901.6
|
caldesmon 1 |
|
| chr13_-_110307131 Show fit | 11.92 |
ENST00000543140.6
ENST00000375820.10 |
collagen type IV alpha 1 chain |
|
| chr1_-_25906457 Show fit | 11.00 |
ENST00000426559.6
|
stathmin 1 |
|
| chr7_+_134779625 Show fit | 10.67 |
ENST00000454108.5
ENST00000361675.7 |
caldesmon 1 |
|
| chr6_+_113857333 Show fit | 10.37 |
ENST00000612661.2
|
myristoylated alanine rich protein kinase C substrate |
|
| chr4_+_41612892 Show fit | 10.26 |
ENST00000509454.5
ENST00000396595.7 ENST00000381753.8 |
LIM and calponin homology domains 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 21.9 | GO:0070495 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 0.0 | 18.8 | GO:0042493 | response to drug(GO:0042493) |
| 4.6 | 18.4 | GO:0032597 | B cell receptor transport within lipid bilayer(GO:0032595) B cell receptor transport into membrane raft(GO:0032597) protein transport out of membrane raft(GO:0032599) chemokine receptor transport out of membrane raft(GO:0032600) negative regulation of transforming growth factor beta3 production(GO:0032913) chemokine receptor transport within lipid bilayer(GO:0033606) |
| 0.0 | 17.1 | GO:0006936 | muscle contraction(GO:0006936) |
| 1.2 | 15.0 | GO:0009414 | response to water deprivation(GO:0009414) |
| 0.2 | 14.3 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 4.7 | 14.2 | GO:0035026 | leading edge cell differentiation(GO:0035026) |
| 0.9 | 13.9 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 2.3 | 13.7 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 1.2 | 13.3 | GO:2000645 | negative regulation of receptor catabolic process(GO:2000645) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 42.1 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 25.3 | GO:0005925 | focal adhesion(GO:0005925) |
| 1.5 | 22.9 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 22.2 | GO:0043197 | dendritic spine(GO:0043197) |
| 2.6 | 21.0 | GO:0005587 | collagen type IV trimer(GO:0005587) |
| 0.0 | 19.2 | GO:0005874 | microtubule(GO:0005874) |
| 0.8 | 18.4 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.3 | 18.4 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 17.2 | GO:0016607 | nuclear speck(GO:0016607) |
| 2.4 | 14.2 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 29.1 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.8 | 22.1 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.7 | 19.8 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.1 | 18.6 | GO:0005178 | integrin binding(GO:0005178) |
| 0.5 | 18.4 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.3 | 18.4 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 18.3 | GO:0003779 | actin binding(GO:0003779) |
| 0.1 | 16.7 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 5.5 | 16.5 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.6 | 14.2 | GO:0098748 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 30.7 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.4 | 24.4 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.2 | 24.0 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.3 | 20.8 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 20.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 17.7 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.9 | 17.5 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.2 | 13.8 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.3 | 12.0 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.2 | 11.2 | PID INSULIN PATHWAY | Insulin Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 39.5 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 30.7 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.3 | 22.2 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.4 | 19.8 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.1 | 19.1 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.8 | 16.5 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.5 | 16.4 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.7 | 14.2 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.3 | 11.0 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.8 | 9.6 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |