Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for SOX8
Z-value: 1.00
Motif logo
Transcription factors associated with SOX8
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX8
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 69.5 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 1.6 | 24.3 | GO:0047484 | regulation of response to osmotic stress(GO:0047484) |
| 0.1 | 19.9 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 2.0 | 18.1 | GO:0072564 | response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
| 0.2 | 17.1 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.2 | 16.8 | GO:0031295 | T cell costimulation(GO:0031295) |
| 4.0 | 15.8 | GO:0035606 | peptidyl-cysteine S-trans-nitrosylation(GO:0035606) |
| 1.7 | 15.5 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 0.4 | 14.7 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.8 | 12.6 | GO:0001778 | plasma membrane repair(GO:0001778) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 84.7 | GO:0016021 | integral component of membrane(GO:0016021) |
| 1.1 | 53.6 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.2 | 20.9 | GO:0005901 | caveola(GO:0005901) |
| 0.1 | 19.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.5 | 18.1 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.9 | 16.2 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 1.9 | 15.5 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.0 | 13.8 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.2 | 12.6 | GO:0030315 | T-tubule(GO:0030315) |
| 0.2 | 11.8 | GO:0043198 | dendritic shaft(GO:0043198) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 53.6 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.2 | 39.5 | GO:0003823 | antigen binding(GO:0003823) |
| 0.3 | 29.4 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.2 | 26.8 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.3 | 25.2 | GO:0001190 | transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811) |
| 0.1 | 20.2 | GO:0003774 | motor activity(GO:0003774) |
| 2.3 | 18.1 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.0 | 17.4 | GO:0004888 | transmembrane signaling receptor activity(GO:0004888) |
| 1.2 | 16.2 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.2 | 16.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 26.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 19.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.5 | 18.2 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.7 | 15.5 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.3 | 14.7 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.2 | 14.7 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.2 | 12.6 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.6 | 12.3 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 11.9 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.3 | 9.4 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 32.8 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 23.0 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.8 | 22.5 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.2 | 18.1 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.8 | 16.2 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.2 | 10.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 9.7 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.9 | 8.0 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.1 | 7.9 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.2 | 7.6 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |