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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SOX9
Z-value: 0.89
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Transcription factors associated with SOX9
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX9 | hg38_v1_chr17_+_72121012_72121033 | 0.13 | 4.7e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX9
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.7 | 33.7 | GO:1904207 | regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
| 5.0 | 29.7 | GO:0071874 | cellular response to norepinephrine stimulus(GO:0071874) |
| 2.8 | 28.4 | GO:0036309 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 1.7 | 27.2 | GO:0070444 | oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445) |
| 2.4 | 23.6 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 1.5 | 21.5 | GO:0030050 | vesicle transport along actin filament(GO:0030050) |
| 0.1 | 19.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.5 | 18.6 | GO:0048665 | neuron fate specification(GO:0048665) |
| 1.6 | 17.1 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 4.3 | 17.0 | GO:0006542 | glutamine biosynthetic process(GO:0006542) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 44.0 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.1 | 41.8 | GO:0005874 | microtubule(GO:0005874) |
| 5.6 | 33.7 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.2 | 28.4 | GO:0005604 | basement membrane(GO:0005604) |
| 0.4 | 26.2 | GO:0031430 | M band(GO:0031430) |
| 0.9 | 23.6 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 4.5 | 22.5 | GO:0072534 | perineuronal net(GO:0072534) |
| 0.1 | 19.9 | GO:0030426 | growth cone(GO:0030426) |
| 0.2 | 18.7 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.6 | 17.4 | GO:0097386 | glial cell projection(GO:0097386) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 57.6 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.7 | 41.6 | GO:0030507 | spectrin binding(GO:0030507) |
| 9.9 | 29.7 | GO:0031696 | alpha-2C adrenergic receptor binding(GO:0031696) |
| 0.9 | 28.9 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.2 | 24.9 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.2 | 22.5 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 20.6 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.8 | 18.4 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
| 4.3 | 17.0 | GO:0004356 | glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880) |
| 0.7 | 16.7 | GO:0031005 | filamin binding(GO:0031005) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.7 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.2 | 14.9 | PID ATR PATHWAY | ATR signaling pathway |
| 0.6 | 13.9 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.7 | 13.6 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.2 | 13.0 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.2 | 9.9 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.2 | 9.3 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
| 0.2 | 8.9 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 8.6 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.1 | 8.3 | PID FGF PATHWAY | FGF signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 31.5 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.2 | 25.4 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.6 | 18.2 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.2 | 14.0 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.5 | 13.9 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.6 | 13.0 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.7 | 10.3 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.1 | 10.1 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 8.8 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.3 | 7.7 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |