Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for SP100
Z-value: 1.44
Motif logo
Transcription factors associated with SP100
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP100 | hg38_v1_chr2_+_230416156_230416186 | 0.31 | 4.1e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP100
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 113.0 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.2 | 79.5 | GO:0008380 | RNA splicing(GO:0008380) |
| 4.2 | 70.9 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
| 4.7 | 61.0 | GO:1900625 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 1.9 | 55.0 | GO:0051084 | 'de novo' posttranslational protein folding(GO:0051084) |
| 0.4 | 52.9 | GO:0007062 | sister chromatid cohesion(GO:0007062) |
| 12.2 | 48.9 | GO:0002188 | translation reinitiation(GO:0002188) |
| 0.4 | 39.0 | GO:1902653 | cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653) |
| 2.3 | 37.0 | GO:0036500 | ATF6-mediated unfolded protein response(GO:0036500) |
| 2.3 | 32.3 | GO:1902166 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.5 | 61.0 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.9 | 60.4 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 1.0 | 58.5 | GO:0005871 | kinesin complex(GO:0005871) |
| 14.1 | 56.4 | GO:1990423 | RZZ complex(GO:1990423) |
| 5.2 | 51.8 | GO:0097255 | R2TP complex(GO:0097255) |
| 3.2 | 48.7 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.1 | 45.4 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.3 | 39.2 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 2.8 | 36.9 | GO:0005688 | U6 snRNP(GO:0005688) |
| 0.1 | 35.8 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 62.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.4 | 55.0 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 1.1 | 53.9 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.7 | 48.9 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 1.7 | 47.1 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 4.1 | 41.0 | GO:0016721 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.5 | 39.4 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 2.6 | 37.0 | GO:0046790 | virion binding(GO:0046790) |
| 1.2 | 36.8 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.5 | 30.9 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 84.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 1.6 | 61.0 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.7 | 43.8 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.5 | 39.9 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.4 | 31.0 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.2 | 27.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.5 | 26.1 | PID ATR PATHWAY | ATR signaling pathway |
| 0.8 | 24.2 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 1.5 | 21.1 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.6 | 20.2 | PID BARD1 PATHWAY | BARD1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 113.0 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 2.5 | 61.0 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.5 | 57.5 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 2.0 | 56.0 | REACTOME KINESINS | Genes involved in Kinesins |
| 1.4 | 54.5 | REACTOME G2 M CHECKPOINTS | Genes involved in G2/M Checkpoints |
| 1.1 | 45.3 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 2.8 | 44.4 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |
| 0.5 | 43.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 2.7 | 38.4 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.3 | 37.5 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |