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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SP3
Z-value: 2.40
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Transcription factors associated with SP3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP3 | hg38_v1_chr2_-_173964180_173964240, hg38_v1_chr2_-_173964069_173964157 | 0.66 | 6.7e-29 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.1 | 1002.6 | GO:0051439 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) |
| 11.4 | 867.6 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 9.2 | 652.4 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 6.4 | 473.9 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 4.4 | 439.0 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 19.3 | 425.1 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 9.2 | 404.1 | GO:0006283 | transcription-coupled nucleotide-excision repair(GO:0006283) |
| 12.4 | 384.7 | GO:0070911 | global genome nucleotide-excision repair(GO:0070911) |
| 15.2 | 380.2 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 5.5 | 365.8 | GO:0090114 | COPII-coated vesicle budding(GO:0090114) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3286.5 | GO:0070062 | extracellular exosome(GO:0070062) |
| 4.6 | 2643.1 | GO:0005925 | focal adhesion(GO:0005925) |
| 7.6 | 1164.5 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 6.5 | 1034.0 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 5.0 | 986.3 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 2.6 | 576.6 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 1.9 | 514.7 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 5.5 | 481.9 | GO:0000776 | kinetochore(GO:0000776) |
| 15.7 | 440.3 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 4.7 | 435.5 | GO:0035578 | azurophil granule lumen(GO:0035578) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.5 | 2177.7 | GO:0045296 | cadherin binding(GO:0045296) |
| 5.9 | 1240.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.6 | 632.3 | GO:0003723 | RNA binding(GO:0003723) |
| 7.8 | 595.4 | GO:0019003 | GDP binding(GO:0019003) |
| 11.4 | 514.1 | GO:0061650 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
| 3.4 | 488.1 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 1.1 | 479.3 | GO:0003712 | transcription cofactor activity(GO:0003712) |
| 14.7 | 411.4 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 2.5 | 379.1 | GO:0005178 | integrin binding(GO:0005178) |
| 2.5 | 374.7 | GO:0042393 | histone binding(GO:0042393) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.2 | 1610.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 9.3 | 509.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 7.8 | 504.7 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 9.9 | 463.6 | PID BARD1 PATHWAY | BARD1 signaling events |
| 5.0 | 423.8 | PID E2F PATHWAY | E2F transcription factor network |
| 5.4 | 391.7 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 8.3 | 382.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 7.1 | 353.5 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 8.0 | 344.5 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 7.6 | 341.6 | PID ATR PATHWAY | ATR signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.4 | 1121.2 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 5.4 | 637.6 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 4.0 | 606.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 10.4 | 595.2 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 18.4 | 590.3 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 13.6 | 544.3 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 7.1 | 538.7 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 16.3 | 538.3 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 9.6 | 538.0 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 4.4 | 505.8 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |