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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SPDEF
Z-value: 1.36
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Transcription factors associated with SPDEF
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SPDEF | hg38_v1_chr6_-_34556319_34556339 | -0.43 | 4.0e-11 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SPDEF
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 136.1 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.6 | 66.1 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.7 | 49.9 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 1.0 | 44.6 | GO:0051123 | RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123) |
| 2.4 | 44.0 | GO:1903504 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
| 2.4 | 37.8 | GO:0021670 | lateral ventricle development(GO:0021670) |
| 0.7 | 37.4 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 8.2 | 32.9 | GO:0006408 | snRNA export from nucleus(GO:0006408) positive regulation of RNA export from nucleus(GO:0046833) |
| 0.8 | 31.8 | GO:0071431 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 10.2 | 30.5 | GO:0016344 | meiotic chromosome movement towards spindle pole(GO:0016344) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 92.3 | GO:0070062 | extracellular exosome(GO:0070062) |
| 2.3 | 76.3 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 4.0 | 72.2 | GO:0031597 | cytosolic proteasome complex(GO:0031597) |
| 7.8 | 69.9 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 4.6 | 55.7 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 11.7 | 46.7 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.5 | 45.7 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 2.3 | 45.2 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 3.1 | 43.8 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 1.5 | 43.5 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.6 | 81.1 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.3 | 73.1 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.7 | 67.8 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 2.0 | 55.7 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 1.1 | 44.6 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.6 | 42.7 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 4.0 | 40.0 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 1.6 | 37.8 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.2 | 33.0 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 3.3 | 32.9 | GO:0000340 | RNA 7-methylguanosine cap binding(GO:0000340) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 50.1 | PID ATR PATHWAY | ATR signaling pathway |
| 0.2 | 47.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.5 | 35.8 | PID BMP PATHWAY | BMP receptor signaling |
| 0.4 | 24.2 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.3 | 23.6 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.7 | 20.7 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 1.6 | 17.1 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.3 | 15.7 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.4 | 15.5 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.3 | 14.4 | PID RAS PATHWAY | Regulation of Ras family activation |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 146.7 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.5 | 69.2 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.6 | 66.7 | REACTOME ASPARAGINE N LINKED GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |
| 1.5 | 65.0 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.9 | 62.6 | REACTOME RNA POL II PRE TRANSCRIPTION EVENTS | Genes involved in RNA Polymerase II Pre-transcription Events |
| 0.8 | 59.6 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 3.3 | 49.0 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 1.3 | 34.9 | REACTOME ADP SIGNALLING THROUGH P2RY12 | Genes involved in ADP signalling through P2Y purinoceptor 12 |
| 0.9 | 33.8 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.9 | 31.8 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |