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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SPI1
Z-value: 3.12
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Transcription factors associated with SPI1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SPI1 | hg38_v1_chr11_-_47378391_47378410, hg38_v1_chr11_-_47378527_47378555 | 0.48 | 4.7e-14 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SPI1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 268.9 | GO:0002433 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) |
| 1.6 | 165.0 | GO:1902036 | regulation of hematopoietic stem cell differentiation(GO:1902036) |
| 18.1 | 145.2 | GO:0050859 | negative regulation of B cell receptor signaling pathway(GO:0050859) |
| 1.1 | 143.5 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 3.9 | 133.6 | GO:0045730 | respiratory burst(GO:0045730) |
| 5.7 | 131.3 | GO:0051639 | actin filament network formation(GO:0051639) |
| 43.6 | 130.7 | GO:0002378 | immunoglobulin biosynthetic process(GO:0002378) |
| 8.5 | 127.8 | GO:0048298 | positive regulation of isotype switching to IgA isotypes(GO:0048298) |
| 3.5 | 125.1 | GO:0070207 | protein homotrimerization(GO:0070207) |
| 6.2 | 117.4 | GO:0035855 | megakaryocyte development(GO:0035855) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 253.7 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 3.2 | 205.2 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.1 | 201.1 | GO:0070062 | extracellular exosome(GO:0070062) |
| 7.7 | 192.0 | GO:0001891 | phagocytic cup(GO:0001891) |
| 2.3 | 177.4 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 15.6 | 171.3 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 18.2 | 164.1 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.4 | 163.5 | GO:0016607 | nuclear speck(GO:0016607) |
| 1.4 | 146.0 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 17.7 | 124.1 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 234.6 | GO:0051015 | actin filament binding(GO:0051015) |
| 1.0 | 214.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 5.4 | 174.1 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.6 | 170.7 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.5 | 170.6 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 8.4 | 167.1 | GO:0005522 | profilin binding(GO:0005522) |
| 20.5 | 164.1 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 7.2 | 130.5 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 4.4 | 124.1 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.5 | 120.0 | GO:0003713 | transcription coactivator activity(GO:0003713) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.8 | 589.1 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 4.5 | 416.1 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 3.1 | 266.5 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 5.6 | 244.8 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 2.9 | 197.3 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 1.7 | 195.1 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 1.5 | 178.1 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 3.0 | 146.2 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 1.8 | 139.0 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 4.2 | 125.9 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.5 | 323.7 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 2.2 | 312.9 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 5.5 | 303.2 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 3.1 | 258.8 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 1.5 | 250.7 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 5.3 | 232.0 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 4.4 | 144.3 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.8 | 135.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.0 | 114.6 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 2.1 | 113.1 | REACTOME G1 PHASE | Genes involved in G1 Phase |