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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SPIB
Z-value: 2.79
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Transcription factors associated with SPIB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SPIB | hg38_v1_chr19_+_50418930_50418958 | 0.43 | 2.4e-11 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SPIB
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 165.0 | GO:0050672 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 1.3 | 132.7 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 1.1 | 121.9 | GO:0002819 | regulation of adaptive immune response(GO:0002819) |
| 9.3 | 120.9 | GO:2001300 | lipoxin metabolic process(GO:2001300) |
| 7.5 | 112.2 | GO:0048298 | positive regulation of isotype switching to IgA isotypes(GO:0048298) |
| 4.8 | 96.6 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 29.6 | 88.8 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 0.6 | 85.3 | GO:1990823 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 5.0 | 85.2 | GO:0045651 | positive regulation of macrophage differentiation(GO:0045651) |
| 14.0 | 84.3 | GO:0061502 | early endosome to recycling endosome transport(GO:0061502) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 249.2 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.7 | 213.1 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 1.2 | 192.0 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.9 | 155.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.2 | 134.3 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.3 | 133.3 | GO:0031965 | nuclear membrane(GO:0031965) |
| 5.0 | 130.0 | GO:0001891 | phagocytic cup(GO:0001891) |
| 1.3 | 118.3 | GO:0035580 | specific granule lumen(GO:0035580) |
| 19.3 | 96.6 | GO:0034688 | integrin alphaM-beta2 complex(GO:0034688) |
| 1.4 | 96.4 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 215.6 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 9.0 | 152.4 | GO:0019864 | IgG binding(GO:0019864) |
| 6.3 | 133.3 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 2.7 | 131.2 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 4.2 | 125.0 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 24.2 | 120.9 | GO:0004464 | leukotriene-C4 synthase activity(GO:0004464) |
| 0.3 | 105.1 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 34.9 | 104.8 | GO:0050528 | acyloxyacyl hydrolase activity(GO:0050528) |
| 0.3 | 104.1 | GO:0003924 | GTPase activity(GO:0003924) |
| 13.8 | 96.6 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.0 | 198.0 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 3.6 | 190.7 | PID EPO PATHWAY | EPO signaling pathway |
| 1.9 | 158.1 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 5.6 | 140.6 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 3.0 | 133.3 | PID RAS PATHWAY | Regulation of Ras family activation |
| 2.7 | 123.0 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 1.9 | 122.8 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 1.5 | 112.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 3.7 | 110.1 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.3 | 109.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 290.7 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 4.9 | 133.4 | REACTOME REGULATION OF KIT SIGNALING | Genes involved in Regulation of KIT signaling |
| 3.3 | 129.1 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 1.0 | 121.4 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 0.7 | 120.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.6 | 120.0 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 1.4 | 115.1 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 4.9 | 108.5 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 3.1 | 103.9 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 1.2 | 85.9 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |