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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SPIC
Z-value: 2.64
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Transcription factors associated with SPIC
Network of associatons between targets according to the STRING database.
First level regulatory network of SPIC
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 233.6 | GO:0032945 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 5.6 | 210.9 | GO:0045730 | respiratory burst(GO:0045730) |
| 0.5 | 209.7 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 0.9 | 152.6 | GO:0038096 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) |
| 5.6 | 118.2 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 8.4 | 109.5 | GO:2001300 | lipoxin metabolic process(GO:2001300) |
| 21.1 | 105.6 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 14.9 | 104.6 | GO:1990822 | basic amino acid transmembrane transport(GO:1990822) |
| 29.0 | 86.9 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 5.9 | 77.3 | GO:0045651 | positive regulation of macrophage differentiation(GO:0045651) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 234.9 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 7.3 | 188.7 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.7 | 186.3 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 20.2 | 181.8 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.1 | 177.5 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 1.7 | 110.1 | GO:0001772 | immunological synapse(GO:0001772) |
| 1.5 | 106.0 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.8 | 99.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 7.5 | 97.0 | GO:0031209 | SCAR complex(GO:0031209) |
| 18.7 | 93.6 | GO:0034688 | integrin alphaM-beta2 complex(GO:0034688) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 268.0 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 22.7 | 181.8 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 2.6 | 155.9 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 21.9 | 109.5 | GO:0004464 | leukotriene-C4 synthase activity(GO:0004464) |
| 8.7 | 104.6 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 5.5 | 94.1 | GO:0019864 | IgG binding(GO:0019864) |
| 0.5 | 90.1 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 10.9 | 86.9 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 4.9 | 77.6 | GO:0015923 | mannosidase activity(GO:0015923) |
| 18.2 | 72.7 | GO:0030107 | HLA-A specific inhibitory MHC class I receptor activity(GO:0030107) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 234.2 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 2.9 | 202.3 | PID EPO PATHWAY | EPO signaling pathway |
| 3.7 | 181.4 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 1.6 | 120.1 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 1.3 | 82.7 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 1.4 | 67.2 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.4 | 52.0 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 1.9 | 50.1 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 2.1 | 47.4 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 1.2 | 43.6 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 319.8 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 1.2 | 218.8 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 4.3 | 187.7 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.7 | 115.9 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 2.8 | 113.4 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 2.3 | 109.0 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 5.6 | 95.9 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 1.6 | 90.6 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 6.1 | 60.9 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.7 | 50.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |