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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SREBF1_TFE3
Z-value: 1.77
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Transcription factors associated with SREBF1_TFE3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TFE3 | hg38_v1_chrX_-_49043345_49043365 | 0.51 | 1.1e-15 | Click! |
| SREBF1 | hg38_v1_chr17_-_17836973_17836993 | 0.01 | 8.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SREBF1_TFE3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.2 | 314.9 | GO:0015988 | energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.4 | 123.7 | GO:0006457 | protein folding(GO:0006457) |
| 9.2 | 92.5 | GO:1904715 | negative regulation of chaperone-mediated autophagy(GO:1904715) |
| 1.9 | 84.3 | GO:0006921 | cellular component disassembly involved in execution phase of apoptosis(GO:0006921) |
| 0.6 | 77.8 | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886) |
| 12.6 | 75.5 | GO:0071874 | cellular response to norepinephrine stimulus(GO:0071874) |
| 19.8 | 59.5 | GO:1902905 | positive regulation of fibril organization(GO:1902905) |
| 0.2 | 59.2 | GO:0010038 | response to metal ion(GO:0010038) |
| 0.5 | 53.4 | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919) |
| 8.1 | 48.3 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 254.6 | GO:0016021 | integral component of membrane(GO:0016021) |
| 1.4 | 208.5 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 10.5 | 167.8 | GO:0033179 | proton-transporting two-sector ATPase complex, proton-transporting domain(GO:0033177) proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 1.8 | 125.7 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.5 | 112.0 | GO:0005770 | late endosome(GO:0005770) |
| 11.6 | 92.8 | GO:0098575 | lumenal side of lysosomal membrane(GO:0098575) |
| 22.0 | 88.0 | GO:0000221 | vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) |
| 0.1 | 73.6 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.3 | 58.9 | GO:0005765 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 4.5 | 58.1 | GO:0097413 | Lewy body(GO:0097413) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 207.1 | GO:0005507 | copper ion binding(GO:0005507) |
| 8.6 | 154.1 | GO:0036442 | hydrogen-exporting ATPase activity(GO:0036442) |
| 12.9 | 103.0 | GO:0016997 | exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) |
| 7.9 | 102.2 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 1.9 | 92.1 | GO:0050699 | WW domain binding(GO:0050699) |
| 1.0 | 88.0 | GO:0019003 | GDP binding(GO:0019003) |
| 16.8 | 84.1 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 20.0 | 79.8 | GO:0005163 | nerve growth factor receptor binding(GO:0005163) |
| 3.5 | 73.8 | GO:0015929 | hexosaminidase activity(GO:0015929) |
| 0.5 | 67.7 | GO:0001618 | virus receptor activity(GO:0001618) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 150.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.6 | 66.4 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 1.4 | 62.3 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.3 | 52.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.5 | 40.7 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.6 | 39.9 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 1.1 | 35.3 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.7 | 33.5 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.4 | 32.4 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.6 | 31.8 | PID AURORA A PATHWAY | Aurora A signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.4 | 312.1 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 3.4 | 176.9 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.5 | 107.6 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.9 | 100.1 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 1.7 | 78.5 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 1.1 | 74.5 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.8 | 62.8 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 4.0 | 60.7 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.6 | 55.3 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.1 | 35.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |