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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SREBF2
Z-value: 0.66
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Transcription factors associated with SREBF2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SREBF2 | hg38_v1_chr22_+_41833079_41833142 | 0.07 | 3.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SREBF2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.5 | 32.3 | GO:0019747 | regulation of isoprenoid metabolic process(GO:0019747) |
| 0.8 | 15.0 | GO:0006107 | oxaloacetate metabolic process(GO:0006107) |
| 1.4 | 12.6 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 1.4 | 8.7 | GO:0008204 | ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204) |
| 0.4 | 8.7 | GO:0033689 | negative regulation of osteoblast proliferation(GO:0033689) |
| 1.2 | 8.4 | GO:0048050 | post-embryonic eye morphogenesis(GO:0048050) |
| 0.7 | 7.5 | GO:0032914 | positive regulation of transforming growth factor beta1 production(GO:0032914) |
| 0.5 | 6.6 | GO:0051599 | response to hydrostatic pressure(GO:0051599) |
| 2.1 | 6.3 | GO:1905167 | positive regulation of lysosomal protein catabolic process(GO:1905167) |
| 0.6 | 6.3 | GO:2000189 | positive regulation of cholesterol homeostasis(GO:2000189) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 47.3 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 4.2 | 12.6 | GO:0016222 | procollagen-proline 4-dioxygenase complex(GO:0016222) |
| 0.1 | 9.4 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.7 | 8.8 | GO:0005583 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.2 | 6.6 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 6.5 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.6 | 6.3 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.2 | 6.3 | GO:0043218 | compact myelin(GO:0043218) |
| 0.0 | 6.3 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.0 | 6.0 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 38.5 | GO:0015485 | cholesterol binding(GO:0015485) |
| 3.0 | 20.8 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 2.5 | 12.6 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) |
| 1.4 | 8.7 | GO:0051996 | farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996) |
| 2.1 | 8.4 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 0.1 | 7.5 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 7.2 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.8 | 6.3 | GO:0030229 | very-low-density lipoprotein particle receptor activity(GO:0030229) |
| 2.0 | 5.9 | GO:0005017 | platelet-derived growth factor-activated receptor activity(GO:0005017) |
| 0.2 | 5.6 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 8.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 6.8 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 6.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 6.6 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 6.3 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 5.9 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.1 | 5.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 4.7 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 4.5 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 23.2 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.4 | 14.4 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.3 | 8.1 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.5 | 7.5 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 6.4 | REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.3 | 6.3 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.3 | 5.6 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.1 | 3.9 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 3.5 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.2 | 3.2 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |