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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SRF
Z-value: 1.95
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Transcription factors associated with SRF
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SRF | hg38_v1_chr6_+_43171260_43171281 | 0.05 | 4.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SRF
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 267.1 | GO:0045652 | regulation of megakaryocyte differentiation(GO:0045652) |
| 30.3 | 151.4 | GO:0090131 | mesenchyme migration(GO:0090131) |
| 0.3 | 125.3 | GO:0007517 | muscle organ development(GO:0007517) |
| 19.0 | 76.1 | GO:0055014 | atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014) |
| 10.3 | 62.1 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 11.6 | 34.9 | GO:0098759 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) interleukin-1 beta biosynthetic process(GO:0050720) response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759) regulation of progesterone biosynthetic process(GO:2000182) |
| 2.3 | 34.9 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 2.9 | 34.8 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 8.9 | 26.8 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) |
| 0.4 | 25.2 | GO:0033275 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.5 | 307.5 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 1.7 | 158.5 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 1.7 | 79.0 | GO:0031430 | M band(GO:0031430) |
| 8.8 | 61.3 | GO:0032982 | myosin filament(GO:0032982) |
| 7.4 | 59.3 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.1 | 52.5 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 46.6 | GO:0005615 | extracellular space(GO:0005615) |
| 12.2 | 36.7 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 5.1 | 25.3 | GO:0042643 | actomyosin, actin portion(GO:0042643) |
| 0.3 | 23.6 | GO:0035577 | azurophil granule membrane(GO:0035577) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.5 | 283.6 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 1.0 | 76.1 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.3 | 76.0 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 74.0 | GO:0005524 | ATP binding(GO:0005524) |
| 15.5 | 62.1 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.7 | 58.3 | GO:0017022 | myosin binding(GO:0017022) |
| 0.1 | 45.9 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 7.0 | 34.9 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
| 4.4 | 34.9 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 1.9 | 34.8 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 291.7 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 2.0 | 115.9 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.4 | 84.5 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 2.0 | 76.1 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 1.0 | 61.4 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.7 | 36.7 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 1.1 | 34.9 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.3 | 34.9 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.5 | 22.8 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.6 | 22.7 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.3 | 456.3 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.6 | 99.7 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.8 | 42.8 | REACTOME MUSCLE CONTRACTION | Genes involved in Muscle contraction |
| 0.4 | 40.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 24.9 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.2 | 23.7 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.8 | 22.7 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.6 | 21.7 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.7 | 17.6 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.2 | 15.4 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |