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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SRF

Z-value: 1.95

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Transcription factors associated with SRF

Gene Symbol Gene ID Gene Info
SRF
ENSG00000112658.8 SRF

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SRFhg38_v1_chr6_+_43171260_431712810.054.3e-01Click!

Activity profile of SRF motif

Sorted Z-values of SRF motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SRF

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr20_+_36541511 133.69 ENST00000279022.7
MYL9
myosin light chain 9
chr20_+_36541484 133.44 ENST00000346786.2
MYL9
myosin light chain 9
chr11_+_117199363 62.93 ENST00000392951.9
ENST00000525531.5
ENST00000278968.10
TAGLN
transgelin
chr2_+_73892967 61.28 ENST00000409731.7
ENST00000409918.5
ENST00000442912.5
ENST00000345517.8
ENST00000409624.1
ACTG2
actin gamma 2, smooth muscle
chr2_-_105438503 39.13 ENST00000393352.7
ENST00000607522.1
FHL2
four and a half LIM domains 2
chr2_-_105398978 36.97 ENST00000408995.5
ENST00000530340.6
ENST00000393353.7
ENST00000322142.13
ENST00000344213.9
ENST00000358129.8
FHL2
four and a half LIM domains 2
chr10_-_88952763 36.68 ENST00000224784.10
ACTA2
actin alpha 2, smooth muscle
chr19_-_45322867 34.88 ENST00000221476.4
CKM
creatine kinase, M-type
chr5_+_138465472 34.86 ENST00000239938.5
EGR1
early growth response 1
chr3_-_123620571 31.03 ENST00000583087.5
MYLK
myosin light chain kinase
chr3_-_123620496 31.02 ENST00000578202.1
MYLK
myosin light chain kinase
chr1_-_229434086 28.20 ENST00000366684.7
ENST00000684723.1
ENST00000366683.4
ACTA1
actin alpha 1, skeletal muscle
chr5_+_151025343 26.81 ENST00000521632.1
GPX3
glutathione peroxidase 3
chr15_-_34795541 25.28 ENST00000290378.6
ACTC1
actin alpha cardiac muscle 1
chr8_+_96584920 22.74 ENST00000521590.5
SDC2
syndecan 2
chr10_-_29634964 22.23 ENST00000375398.6
ENST00000355867.8
SVIL
supervillin
chr1_+_223701582 20.53 ENST00000433674.6
CAPN2
calpain 2
chr7_-_94656197 20.44 ENST00000643903.1
ENST00000644122.1
ENST00000447873.6
ENST00000644816.1
ENST00000644375.1
SGCE
sarcoglycan epsilon
chr7_-_94655993 19.53 ENST00000647110.1
ENST00000647048.1
ENST00000643020.1
ENST00000644682.1
ENST00000646119.1
ENST00000646265.1
ENST00000645445.1
ENST00000647334.1
ENST00000645262.1
ENST00000428696.7
ENST00000647096.1
ENST00000642394.1
ENST00000645725.1
ENST00000647351.1
ENST00000646943.1
ENST00000648936.2
ENST00000642707.1
ENST00000645109.1
ENST00000646489.1
ENST00000642933.1
ENST00000643128.1
ENST00000445866.7
ENST00000645101.1
ENST00000644116.1
ENST00000642441.1
ENST00000646879.1
ENST00000647018.1
SGCE
sarcoglycan epsilon
chr7_-_94656160 19.29 ENST00000644609.1
ENST00000643272.1
ENST00000646137.1
ENST00000646098.1
ENST00000643193.1
ENST00000437425.7
ENST00000644551.1
ENST00000415788.3
SGCE
sarcoglycan epsilon
chr19_-_35757009 18.52 ENST00000587965.1
ENST00000004982.6
HSPB6
heat shock protein family B (small) member 6
chr3_-_99876193 18.44 ENST00000383694.3
FILIP1L
filamin A interacting protein 1 like
chr14_+_75278820 17.58 ENST00000554617.1
ENST00000554212.5
ENST00000535987.5
ENST00000303562.9
ENST00000555242.1
FOS
Fos proto-oncogene, AP-1 transcription factor subunit
chr6_+_151240368 17.57 ENST00000253332.5
AKAP12
A-kinase anchoring protein 12
chr3_-_52452828 17.54 ENST00000496590.1
TNNC1
troponin C1, slow skeletal and cardiac type
chr15_+_96330691 17.29 ENST00000394166.8
NR2F2
nuclear receptor subfamily 2 group F member 2
chr6_+_151239951 17.26 ENST00000402676.7
AKAP12
A-kinase anchoring protein 12
chr10_+_73998104 17.25 ENST00000372755.7
ENST00000211998.10
VCL
vinculin
chr3_-_99876104 15.43 ENST00000471562.1
ENST00000495625.2
FILIP1L
filamin A interacting protein 1 like
chr7_-_108003122 15.19 ENST00000393559.2
ENST00000222399.11
ENST00000676777.1
ENST00000439976.6
ENST00000393560.5
ENST00000677793.1
ENST00000679244.1
LAMB1
laminin subunit beta 1
chr3_+_188212931 14.44 ENST00000618621.4
ENST00000640853.1
LPP
LIM domain containing preferred translocation partner in lipoma
chr3_-_46863435 14.06 ENST00000395869.5
ENST00000653454.1
ENST00000292327.6
MYL3
myosin light chain 3
chr12_+_75480800 13.40 ENST00000456650.7
GLIPR1
GLI pathogenesis related 1
chr1_+_19644284 13.28 ENST00000375136.8
NBL1
NBL1, DAN family BMP antagonist
chr17_+_44557476 13.25 ENST00000315323.5
FZD2
frizzled class receptor 2
chr7_-_80919017 12.44 ENST00000265361.8
SEMA3C
semaphorin 3C
chr6_-_3751703 12.04 ENST00000380283.5
PXDC1
PX domain containing 1
chr19_+_16067526 11.89 ENST00000646974.2
TPM4
tropomyosin 4
chr11_-_65900375 11.82 ENST00000312562.7
FOSL1
FOS like 1, AP-1 transcription factor subunit
chr12_-_50222694 11.73 ENST00000552783.5
LIMA1
LIM domain and actin binding 1
chr19_+_2476118 11.65 ENST00000215631.9
ENST00000587345.1
GADD45B
growth arrest and DNA damage inducible beta
chr19_+_45467988 11.61 ENST00000615753.4
ENST00000585836.5
ENST00000417353.6
ENST00000591858.5
ENST00000443841.6
ENST00000590335.1
ENST00000353609.8
FOSB
FosB proto-oncogene, AP-1 transcription factor subunit
chr11_-_65900413 11.02 ENST00000448083.6
ENST00000531493.5
ENST00000532401.1
FOSL1
FOS like 1, AP-1 transcription factor subunit
chr1_-_89065200 10.98 ENST00000370473.5
GBP1
guanylate binding protein 1
chr19_+_13151975 10.72 ENST00000588173.1
IER2
immediate early response 2
chr2_-_127675065 10.61 ENST00000545738.6
ENST00000409808.6
LIMS2
LIM zinc finger domain containing 2
chr12_-_50222348 10.52 ENST00000552823.5
ENST00000552909.5
LIMA1
LIM domain and actin binding 1
chr10_+_122163426 10.35 ENST00000360561.7
TACC2
transforming acidic coiled-coil containing protein 2
chr12_+_75480745 10.18 ENST00000266659.8
GLIPR1
GLI pathogenesis related 1
chr2_-_208254232 10.04 ENST00000415913.5
ENST00000415282.5
ENST00000446179.5
IDH1
isocitrate dehydrogenase (NADP(+)) 1
chr7_+_143381286 9.85 ENST00000449630.5
ENST00000322764.10
ENST00000457235.5
ZYX
zyxin
chr2_-_127675459 9.80 ENST00000355119.9
LIMS2
LIM zinc finger domain containing 2
chr16_+_56932134 9.57 ENST00000439977.7
ENST00000300302.9
ENST00000344114.8
ENST00000379792.6
HERPUD1
homocysteine inducible ER protein with ubiquitin like domain 1
chr7_-_27143672 9.27 ENST00000222726.4
HOXA5
homeobox A5
chr16_-_11281322 9.09 ENST00000312511.4
PRM1
protamine 1
chr7_+_143381561 9.09 ENST00000354434.8
ZYX
zyxin
chr20_+_4721901 8.67 ENST00000305817.3
PRND
prion like protein doppel
chr1_+_11934651 8.16 ENST00000449038.5
ENST00000196061.5
ENST00000429000.6
PLOD1
procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
chr19_+_1026566 8.16 ENST00000562015.5
ENST00000263097.9
ENST00000348419.7
ENST00000565096.6
ENST00000562958.6
ENST00000568865.3
ENST00000606983.5
ENST00000562075.6
ENST00000607102.1
CNN2
calponin 2
chr10_-_17617326 7.95 ENST00000326961.6
ENST00000361271.8
HACD1
3-hydroxyacyl-CoA dehydratase 1
chr16_+_30372291 7.84 ENST00000568749.5
MYLPF
myosin light chain, phosphorylatable, fast skeletal muscle
chr1_-_207911384 7.77 ENST00000356522.4
CD34
CD34 molecule
chr1_-_207911027 7.65 ENST00000310833.12
CD34
CD34 molecule
chr12_+_52051402 7.54 ENST00000243050.5
ENST00000550763.1
ENST00000394825.6
ENST00000394824.2
ENST00000548232.1
ENST00000562373.1
NR4A1
nuclear receptor subfamily 4 group A member 1
chr10_+_110497898 7.54 ENST00000369583.4
DUSP5
dual specificity phosphatase 5
chr10_-_16817362 7.35 ENST00000377921.7
ENST00000345264.10
RSU1
Ras suppressor protein 1
chr10_-_16817443 7.32 ENST00000602389.1
RSU1
Ras suppressor protein 1
chr22_-_35961623 7.22 ENST00000408983.2
RBFOX2
RNA binding fox-1 homolog 2
chr7_-_44141074 6.98 ENST00000457314.5
ENST00000447951.1
ENST00000431007.1
MYL7
myosin light chain 7
chrX_-_32412220 6.76 ENST00000619831.5
DMD
dystrophin
chrX_+_35798791 6.43 ENST00000399985.1
MAGEB16
MAGE family member B16
chr7_-_44141285 6.29 ENST00000458240.5
ENST00000223364.7
MYL7
myosin light chain 7
chr2_+_26692686 6.24 ENST00000620977.1
ENST00000302909.4
KCNK3
potassium two pore domain channel subfamily K member 3
chrX_-_11265975 5.91 ENST00000303025.10
ENST00000657361.1
ARHGAP6
Rho GTPase activating protein 6
chr17_-_81512671 5.86 ENST00000679480.1
ENST00000644774.2
ENST00000571721.6
ENST00000575842.5
ENST00000575087.5
ENST00000573283.7
ENST00000571691.6
ENST00000570382.2
ACTG1
actin gamma 1
chr1_-_85578345 5.83 ENST00000426972.8
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr9_+_89605004 5.50 ENST00000252506.11
ENST00000375769.1
GADD45G
growth arrest and DNA damage inducible gamma
chrX_+_35798342 5.47 ENST00000399988.5
ENST00000399992.5
ENST00000399987.5
ENST00000399989.5
MAGEB16
MAGE family member B16
chr1_-_89126066 5.42 ENST00000370466.4
GBP2
guanylate binding protein 2
chr15_-_65067938 5.33 ENST00000421977.7
ENST00000220062.9
RASL12
RAS like family 12
chr10_-_17617235 5.33 ENST00000466335.1
HACD1
3-hydroxyacyl-CoA dehydratase 1
chr14_-_23408265 5.23 ENST00000405093.9
MYH6
myosin heavy chain 6
chr18_-_3219961 5.09 ENST00000356443.9
MYOM1
myomesin 1
chr12_-_11310420 5.08 ENST00000621732.4
ENST00000445719.2
ENST00000279575.7
PRB4
proline rich protein BstNI subfamily 4
chr5_-_177496845 4.93 ENST00000506537.1
PDLIM7
PDZ and LIM domain 7
chr5_-_177496802 4.72 ENST00000506161.5
PDLIM7
PDZ and LIM domain 7
chr5_+_66958870 4.44 ENST00000405643.5
ENST00000407621.1
ENST00000432426.5
MAST4
microtubule associated serine/threonine kinase family member 4
chr14_-_89417148 4.21 ENST00000557258.6
FOXN3
forkhead box N3
chr17_-_48593748 4.04 ENST00000239151.6
HOXB5
homeobox B5
chr4_+_87006736 3.87 ENST00000544085.6
AFF1
AF4/FMR2 family member 1
chr10_-_62816309 3.78 ENST00000411732.3
EGR2
early growth response 2
chr1_-_11848345 3.70 ENST00000376476.1
NPPA
natriuretic peptide A
chr7_+_94656325 3.18 ENST00000482108.1
ENST00000488574.5
ENST00000612748.1
ENST00000613043.1
PEG10
paternally expressed 10
chr17_-_81514629 3.15 ENST00000681052.1
ENST00000575659.6
ACTG1
actin gamma 1
chr2_-_207167220 3.05 ENST00000421199.5
ENST00000457962.5
KLF7
Kruppel like factor 7
chr2_-_160200289 3.05 ENST00000409872.1
ITGB6
integrin subunit beta 6
chr18_-_3219849 3.04 ENST00000261606.11
MYOM1
myomesin 1
chr1_-_11847772 2.88 ENST00000376480.7
ENST00000610706.1
NPPA
natriuretic peptide A
chr2_-_160200310 2.83 ENST00000620391.4
ITGB6
integrin subunit beta 6
chr5_+_93583212 2.78 ENST00000327111.8
NR2F1
nuclear receptor subfamily 2 group F member 1
chr4_+_87006988 2.77 ENST00000307808.10
AFF1
AF4/FMR2 family member 1
chr8_+_85438850 2.73 ENST00000285381.3
CA3
carbonic anhydrase 3
chr2_-_160200251 2.67 ENST00000428609.6
ENST00000409967.6
ENST00000283249.7
ITGB6
integrin subunit beta 6
chr19_+_57389839 2.67 ENST00000366197.9
ENST00000336128.12
ENST00000596282.5
ENST00000597400.5
ENST00000598895.5
ENST00000596617.5
ZNF548
ENSG00000269533.5
zinc finger protein 548
novel transcript
chr5_-_33891941 2.57 ENST00000352040.7
ENST00000504830.6
ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif 12
chr11_-_47352693 2.41 ENST00000256993.8
ENST00000399249.6
ENST00000545968.6
MYBPC3
myosin binding protein C3
chr7_-_5530581 2.34 ENST00000676397.1
ENST00000645576.1
ENST00000674681.1
ENST00000646664.1
ENST00000493945.6
ENST00000676319.1
ENST00000473257.3
ENST00000647275.1
ENST00000432588.6
ACTB
actin beta
chr11_-_2141238 2.12 ENST00000434045.6
IGF2
insulin like growth factor 2
chr8_+_2045058 1.85 ENST00000523438.1
MYOM2
myomesin 2
chr20_-_35147285 1.82 ENST00000374491.3
ENST00000374492.8
EDEM2
ER degradation enhancing alpha-mannosidase like protein 2
chr12_+_18242955 1.78 ENST00000676171.1
PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr16_+_30065777 1.77 ENST00000395240.7
ENST00000566846.5
ALDOA
aldolase, fructose-bisphosphate A
chr10_+_31321152 1.67 ENST00000446923.7
ZEB1
zinc finger E-box binding homeobox 1
chr11_-_2140967 1.67 ENST00000381389.5
IGF2
insulin like growth factor 2
chr10_+_6144883 1.66 ENST00000379789.8
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr8_+_2045037 1.64 ENST00000262113.9
MYOM2
myomesin 2
chr17_+_7583828 1.54 ENST00000396501.8
ENST00000250124.11
ENST00000584378.5
ENST00000423172.6
ENST00000579445.5
ENST00000585217.5
ENST00000581380.1
MPDU1
mannose-P-dolichol utilization defect 1
chr16_+_30065753 1.18 ENST00000642816.3
ENST00000643777.4
ENST00000569798.5
ALDOA
aldolase, fructose-bisphosphate A
chr3_-_9792691 1.01 ENST00000343450.2
TADA3
transcriptional adaptor 3
chr12_-_27780236 0.99 ENST00000381273.4
MANSC4
MANSC domain containing 4
chr12_+_59596010 0.93 ENST00000547379.6
ENST00000552432.5
SLC16A7
solute carrier family 16 member 7
chr19_-_17245889 0.86 ENST00000291442.4
NR2F6
nuclear receptor subfamily 2 group F member 6
chr5_-_58999885 0.85 ENST00000317118.12
PDE4D
phosphodiesterase 4D
chr10_-_62816341 0.66 ENST00000242480.4
ENST00000637191.1
EGR2
early growth response 2
chr2_+_206159580 0.60 ENST00000236957.9
ENST00000392221.5
ENST00000445505.5
EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr5_-_54310545 0.54 ENST00000504924.6
ENST00000620747.4
ENST00000507646.2
ENST00000502271.5
ARL15
ADP ribosylation factor like GTPase 15
chr12_-_11395556 0.43 ENST00000565533.1
ENST00000389362.6
ENST00000546254.3
PRB2
PRB1
proline rich protein BstNI subfamily 2
proline rich protein BstNI subfamily 1
chr1_-_168137430 0.29 ENST00000546300.5
ENST00000271357.9
ENST00000367835.1
ENST00000537209.5
GPR161
G protein-coupled receptor 161
chr13_+_27251545 0.20 ENST00000311549.11
RPL21
ribosomal protein L21
chr15_+_83107572 0.15 ENST00000379390.10
ENST00000322019.14
ENST00000565774.5
ENST00000565982.1
TM6SF1
transmembrane 6 superfamily member 1
chr3_+_9792495 0.14 ENST00000498623.6
ARPC4
actin related protein 2/3 complex subunit 4
chr12_-_6663083 0.14 ENST00000467678.5
ENST00000493873.1
ENST00000412586.6
ENST00000423703.6
ENST00000444704.5
ENST00000341550.9
ING4
inhibitor of growth family member 4
chr12_-_6663136 0.12 ENST00000396807.8
ENST00000619641.4
ENST00000446105.6
ING4
inhibitor of growth family member 4
chr5_-_179623659 0.09 ENST00000519056.5
ENST00000506721.5
ENST00000503105.5
ENST00000504348.5
ENST00000508103.5
ENST00000510431.5
ENST00000515158.5
ENST00000393432.8
ENST00000442819.6
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1
chr3_+_9793074 0.06 ENST00000397261.8
ENST00000485273.1
ENST00000433034.1
ENST00000397256.5
ARPC4
ARPC4-TTLL3
actin related protein 2/3 complex subunit 4
ARPC4-TTLL3 readthrough
chr18_-_56651122 0.06 ENST00000590954.5
TXNL1
thioredoxin like 1
chr3_-_9792404 0.01 ENST00000301964.7
TADA3
transcriptional adaptor 3
chr11_+_4704782 0.01 ENST00000380390.6
MMP26
matrix metallopeptidase 26

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
30.3 151.4 GO:0090131 mesenchyme migration(GO:0090131)
19.0 76.1 GO:0055014 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
11.6 34.9 GO:0098759 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) interleukin-1 beta biosynthetic process(GO:0050720) response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759) regulation of progesterone biosynthetic process(GO:2000182)
10.3 62.1 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
8.9 26.8 GO:0006982 response to lipid hydroperoxide(GO:0006982)
5.8 17.5 GO:0002086 diaphragm contraction(GO:0002086)
5.1 15.4 GO:0035759 mesangial cell-matrix adhesion(GO:0035759) positive regulation of granulocyte colony-stimulating factor production(GO:0071657) metanephric mesangial cell differentiation(GO:0072209) metanephric glomerular mesangial cell differentiation(GO:0072254) positive regulation of macrophage colony-stimulating factor production(GO:1901258)
4.3 17.3 GO:0009956 radial pattern formation(GO:0009956) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
3.8 22.8 GO:0007296 vitellogenesis(GO:0007296)
3.8 22.7 GO:0008218 bioluminescence(GO:0008218)
3.3 10.0 GO:0006097 glyoxylate cycle(GO:0006097)
3.3 267.1 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652)
3.3 13.3 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
3.1 9.3 GO:0060435 bronchiole development(GO:0060435)
2.9 34.8 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
2.7 11.0 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
2.5 12.4 GO:0003350 pulmonary myocardium development(GO:0003350)
2.3 11.6 GO:0002074 extraocular skeletal muscle development(GO:0002074)
2.3 34.9 GO:0006600 creatine metabolic process(GO:0006600)
2.0 20.4 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
2.0 8.2 GO:0046946 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
2.0 17.6 GO:0001661 conditioned taste aversion(GO:0001661)
1.7 13.3 GO:0003150 muscular septum morphogenesis(GO:0003150)
1.5 4.4 GO:0021593 rhombomere morphogenesis(GO:0021593) rhombomere 3 morphogenesis(GO:0021658)
1.4 7.2 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724) definitive erythrocyte differentiation(GO:0060318)
1.1 6.6 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
1.1 7.5 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
1.0 5.2 GO:0055009 atrial cardiac muscle tissue development(GO:0003228) atrial cardiac muscle tissue morphogenesis(GO:0055009)
1.0 15.6 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.9 1.8 GO:1904154 positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.8 15.2 GO:0016540 protein autoprocessing(GO:0016540)
0.8 2.4 GO:0032971 regulation of muscle filament sliding(GO:0032971)
0.8 9.6 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.8 13.3 GO:0030497 fatty acid elongation(GO:0030497) very long-chain fatty acid biosynthetic process(GO:0042761)
0.8 2.3 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.8 8.5 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.7 17.1 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.6 18.5 GO:0010667 negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.5 3.8 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.5 6.8 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.5 6.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.5 2.6 GO:1902202 proteoglycan catabolic process(GO:0030167) regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.5 7.5 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.5 11.6 GO:0051412 response to corticosterone(GO:0051412)
0.4 22.2 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.4 8.7 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.4 25.2 GO:0033275 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.4 22.2 GO:0031529 ruffle organization(GO:0031529)
0.3 5.8 GO:1900038 negative regulation of cellular response to hypoxia(GO:1900038)
0.3 15.2 GO:0021801 cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.3 8.9 GO:0045214 sarcomere organization(GO:0045214)
0.3 4.2 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.3 1.7 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.3 125.3 GO:0007517 muscle organ development(GO:0007517)
0.3 9.1 GO:0030261 chromosome condensation(GO:0030261)
0.2 1.7 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.2 5.9 GO:1903392 negative regulation of focal adhesion assembly(GO:0051895) negative regulation of adherens junction organization(GO:1903392)
0.2 18.9 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.2 2.9 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 8.2 GO:0031032 actomyosin structure organization(GO:0031032)
0.1 0.9 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.1 9.6 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.1 0.8 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 1.0 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.1 1.5 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.1 10.8 GO:0071774 response to fibroblast growth factor(GO:0071774)
0.1 1.8 GO:0039703 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0 4.0 GO:0048704 embryonic skeletal system morphogenesis(GO:0048704)
0.0 2.7 GO:0015701 bicarbonate transport(GO:0015701)
0.0 3.2 GO:1903845 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.0 5.4 GO:0071357 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0 0.9 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0 12.4 GO:0006936 muscle contraction(GO:0006936)
0.0 0.3 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0 2.7 GO:0021987 cerebral cortex development(GO:0021987)
0.0 0.1 GO:0018094 protein polyglycylation(GO:0018094)
0.0 2.8 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.0 8.9 GO:0019216 regulation of lipid metabolic process(GO:0019216)
0.0 0.3 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 3.1 GO:0007411 axon guidance(GO:0007411)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
12.2 36.7 GO:0030485 smooth muscle contractile fiber(GO:0030485)
8.8 61.3 GO:0032982 myosin filament(GO:0032982)
7.5 307.5 GO:0005859 muscle myosin complex(GO:0005859)
7.4 59.3 GO:0016012 sarcoglycan complex(GO:0016012)
5.1 15.2 GO:0005606 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
5.1 25.3 GO:0042643 actomyosin, actin portion(GO:0042643)
2.9 17.5 GO:1990584 cardiac Troponin complex(GO:1990584)
2.5 22.2 GO:0036449 microtubule minus-end(GO:0036449)
2.2 17.6 GO:0035976 AP1 complex(GO:0035976)
2.1 8.5 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
1.7 158.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
1.7 79.0 GO:0031430 M band(GO:0031430)
1.4 9.6 GO:1990037 Lewy body core(GO:1990037)
1.0 15.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.9 17.3 GO:0005916 fascia adherens(GO:0005916)
0.8 11.3 GO:0097433 dense body(GO:0097433)
0.7 15.4 GO:0046930 pore complex(GO:0046930)
0.6 13.3 GO:0031672 A band(GO:0031672)
0.6 6.8 GO:0016013 syntrophin complex(GO:0016013)
0.5 9.1 GO:0000786 nucleosome(GO:0000786)
0.3 23.6 GO:0035577 azurophil granule membrane(GO:0035577)
0.3 8.2 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.2 22.8 GO:0042734 presynaptic membrane(GO:0042734)
0.2 13.3 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.2 10.0 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 22.7 GO:0005796 Golgi lumen(GO:0005796)
0.2 6.6 GO:0042629 mast cell granule(GO:0042629)
0.1 1.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 6.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 13.3 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 52.5 GO:0005925 focal adhesion(GO:0005925)
0.1 1.0 GO:0000124 SAGA complex(GO:0000124)
0.1 1.8 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 5.9 GO:0005884 actin filament(GO:0005884)
0.1 8.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 3.8 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 46.6 GO:0005615 extracellular space(GO:0005615)
0.0 4.0 GO:0001650 fibrillar center(GO:0001650)
0.0 13.4 GO:0000139 Golgi membrane(GO:0000139)
0.0 2.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 11.2 GO:0005815 microtubule organizing center(GO:0005815)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
15.5 62.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
13.5 283.6 GO:0032036 myosin heavy chain binding(GO:0032036)
7.0 34.9 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
4.4 13.3 GO:0080023 3R-hydroxyacyl-CoA dehydratase activity(GO:0080023)
4.4 34.9 GO:0004111 creatine kinase activity(GO:0004111)
3.3 10.0 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
2.2 26.8 GO:0008430 selenium binding(GO:0008430)
2.0 8.2 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
1.9 34.8 GO:0008179 adenylate cyclase binding(GO:0008179)
1.8 17.5 GO:0031013 troponin I binding(GO:0031013)
1.5 15.4 GO:0043199 sulfate binding(GO:0043199)
1.5 13.3 GO:0016015 morphogen activity(GO:0016015)
1.2 17.3 GO:0045294 alpha-catenin binding(GO:0045294)
1.0 76.1 GO:0050681 androgen receptor binding(GO:0050681)
0.9 2.8 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.9 4.4 GO:0017018 myosin phosphatase activity(GO:0017018)
0.8 5.8 GO:0016403 dimethylargininase activity(GO:0016403)
0.8 2.3 GO:0098973 structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.8 12.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.7 58.3 GO:0017022 myosin binding(GO:0017022)
0.6 22.2 GO:0003785 actin monomer binding(GO:0003785)
0.6 6.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.6 18.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.6 11.6 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.6 13.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.5 17.3 GO:0001972 retinoic acid binding(GO:0001972)
0.4 22.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.4 15.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.3 76.0 GO:0051015 actin filament binding(GO:0051015)
0.3 0.9 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.3 1.7 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.3 2.9 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 1.8 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.2 11.0 GO:0030507 spectrin binding(GO:0030507)
0.2 1.8 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.2 22.7 GO:0030165 PDZ domain binding(GO:0030165)
0.2 6.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 7.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 15.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.2 2.7 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 4.0 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 8.7 GO:0005507 copper ion binding(GO:0005507)
0.1 45.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 3.8 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 9.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 10.4 GO:0035257 nuclear hormone receptor binding(GO:0035257)
0.1 1.7 GO:0070888 E-box binding(GO:0070888)
0.1 8.5 GO:0001618 virus receptor activity(GO:0001618)
0.1 0.9 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.1 1.0 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 5.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 8.3 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 12.0 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 74.0 GO:0005524 ATP binding(GO:0005524)
0.0 0.8 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 7.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 2.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0047134 protein-disulfide reductase activity(GO:0047134)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 291.7 PID ILK PATHWAY Integrin-linked kinase signaling
2.0 115.9 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
2.0 76.1 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
1.1 34.9 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
1.0 61.4 PID RHOA PATHWAY RhoA signaling pathway
0.8 15.2 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.7 36.7 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.6 9.6 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.6 22.7 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.5 22.8 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.5 17.1 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.4 15.2 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.4 84.5 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.4 13.3 PID WNT SIGNALING PATHWAY Wnt signaling network
0.4 8.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.3 34.9 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.3 18.2 PID AP1 PATHWAY AP-1 transcription factor network
0.3 17.3 PID HNF3A PATHWAY FOXA1 transcription factor network
0.2 7.5 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.2 22.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.2 7.5 PID ATF2 PATHWAY ATF-2 transcription factor network
0.2 7.8 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.1 13.6 PID CMYB PATHWAY C-MYB transcription factor network
0.1 0.4 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 4.4 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 3.8 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 12.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.3 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 3.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 7.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
8.3 456.3 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.9 6.2 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.8 22.7 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.8 42.8 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.8 6.6 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.7 17.6 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.6 99.7 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.6 21.7 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.4 40.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.4 12.0 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.3 10.0 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.3 9.6 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.2 15.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 23.7 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 7.5 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.2 11.0 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.2 2.7 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.2 3.8 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 8.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 1.8 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 13.3 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 24.9 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 4.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 1.8 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 0.9 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 2.3 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 3.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.8 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events