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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SRY
Z-value: 1.02
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Transcription factors associated with SRY
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SRY | hg38_v1_chrY_-_2787676_2787687 | 0.35 | 1.0e-07 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SRY
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.0 | 84.4 | GO:0030050 | vesicle transport along actin filament(GO:0030050) |
| 0.3 | 71.8 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 1.7 | 40.8 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
| 0.7 | 31.9 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.1 | 25.1 | GO:0043401 | steroid hormone mediated signaling pathway(GO:0043401) |
| 2.5 | 24.9 | GO:0090292 | nuclear matrix anchoring at nuclear membrane(GO:0090292) |
| 4.9 | 24.3 | GO:0002904 | positive regulation of B cell apoptotic process(GO:0002904) |
| 0.0 | 19.6 | GO:0006397 | mRNA processing(GO:0006397) |
| 0.6 | 19.3 | GO:0048665 | neuron fate specification(GO:0048665) |
| 0.1 | 18.9 | GO:0060333 | interferon-gamma-mediated signaling pathway(GO:0060333) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 84.5 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.4 | 76.3 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.5 | 52.8 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 1.0 | 40.8 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 27.1 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 26.6 | GO:0000139 | Golgi membrane(GO:0000139) |
| 1.9 | 24.9 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.6 | 24.0 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.2 | 20.9 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.7 | 16.8 | GO:0044295 | axonal growth cone(GO:0044295) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.0 | 84.4 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 4.0 | 83.3 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.4 | 46.0 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 0.5 | 40.8 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.7 | 31.9 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.8 | 24.9 | GO:0005521 | lamin binding(GO:0005521) |
| 6.1 | 24.3 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.6 | 21.0 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.6 | 19.6 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 4.5 | 17.8 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 78.5 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.4 | 22.1 | PID ATR PATHWAY | ATR signaling pathway |
| 0.2 | 19.9 | PID FGF PATHWAY | FGF signaling pathway |
| 0.6 | 19.6 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.3 | 17.9 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.2 | 15.4 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 15.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 14.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 13.7 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.3 | 10.2 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 80.3 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.3 | 18.9 | REACTOME SIGNAL TRANSDUCTION BY L1 | Genes involved in Signal transduction by L1 |
| 1.1 | 17.9 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.3 | 16.9 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.2 | 16.4 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.4 | 15.4 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.4 | 15.2 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.7 | 13.2 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.3 | 11.9 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.7 | 9.5 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |