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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for STAT1_STAT3_BCL6
Z-value: 1.17
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Transcription factors associated with STAT1_STAT3_BCL6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| STAT1 | hg38_v1_chr2_-_191014137_191014231 | -0.33 | 4.2e-07 | Click! |
| BCL6 | hg38_v1_chr3_-_187736493_187736569 | 0.33 | 4.7e-07 | Click! |
| STAT3 | hg38_v1_chr17_-_42388360_42388463 | 0.05 | 4.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of STAT1_STAT3_BCL6
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_-_27611325 Show fit | 37.06 |
ENST00000523500.5
|
clusterin |
|
| chr1_-_230714112 Show fit | 28.19 |
ENST00000681514.1
ENST00000366667.6 ENST00000680041.1 |
angiotensinogen |
|
| chr8_-_27611424 Show fit | 27.80 |
ENST00000405140.7
|
clusterin |
|
| chr12_-_91146195 Show fit | 23.38 |
ENST00000548218.1
|
decorin |
|
| chr12_-_7092422 Show fit | 21.23 |
ENST00000543835.5
ENST00000647956.2 ENST00000535233.6 |
complement C1r |
|
| chr12_+_53050179 Show fit | 20.63 |
ENST00000546602.5
ENST00000552570.5 ENST00000549700.5 |
tensin 2 |
|
| chr12_+_53050014 Show fit | 20.38 |
ENST00000314250.11
|
tensin 2 |
|
| chr17_+_34255274 Show fit | 20.23 |
ENST00000580907.5
ENST00000225831.4 |
C-C motif chemokine ligand 2 |
|
| chr3_-_50611767 Show fit | 19.92 |
ENST00000443053.6
ENST00000348721.4 |
cytokine inducible SH2 containing protein |
|
| chr11_+_57597563 Show fit | 18.79 |
ENST00000619430.2
ENST00000457869.1 ENST00000340687.10 ENST00000278407.9 ENST00000378323.8 ENST00000378324.6 ENST00000403558.1 |
serpin family G member 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.0 | 64.9 | GO:1902847 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.5 | 52.3 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 1.4 | 41.0 | GO:0014850 | response to muscle activity(GO:0014850) |
| 2.1 | 39.8 | GO:0018214 | peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214) |
| 11.6 | 34.8 | GO:0060739 | mesenchymal-epithelial cell signaling involved in prostate gland development(GO:0060739) |
| 10.3 | 30.8 | GO:0071139 | resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140) |
| 5.8 | 29.2 | GO:0038123 | toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727) |
| 9.4 | 28.2 | GO:0014873 | G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199) response to muscle activity involved in regulation of muscle adaptation(GO:0014873) |
| 1.7 | 26.1 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
| 0.3 | 25.0 | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 137.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 4.3 | 64.9 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.0 | 52.9 | GO:0005615 | extracellular space(GO:0005615) |
| 3.8 | 37.8 | GO:0005614 | interstitial matrix(GO:0005614) |
| 3.2 | 29.2 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 1.7 | 26.2 | GO:0030478 | actin cap(GO:0030478) |
| 1.8 | 23.4 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 19.0 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.0 | 15.7 | GO:0005813 | centrosome(GO:0005813) |
| 1.3 | 15.0 | GO:0005577 | fibrinogen complex(GO:0005577) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 66.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 2.8 | 64.9 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.4 | 52.6 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 3.9 | 34.8 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.3 | 34.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 4.4 | 30.8 | GO:0008821 | crossover junction endodeoxyribonuclease activity(GO:0008821) |
| 7.3 | 29.2 | GO:0016019 | peptidoglycan receptor activity(GO:0016019) |
| 1.6 | 28.2 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 8.5 | 25.4 | GO:0031727 | CCR2 chemokine receptor binding(GO:0031727) |
| 6.2 | 24.7 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 59.0 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.4 | 49.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.2 | 49.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.7 | 43.9 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.2 | 35.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.6 | 24.4 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 1.4 | 19.9 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.6 | 19.0 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 14.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 8.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 66.7 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.4 | 52.8 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 2.9 | 51.6 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.2 | 39.8 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.6 | 30.4 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.5 | 28.7 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 2.1 | 27.0 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.3 | 24.6 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.9 | 23.4 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 1.0 | 22.0 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |