ISMARA results: STAT4

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for STAT4

Z-value: 0.81

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Transcription factors associated with STAT4

Gene Symbol	Gene ID	Gene Info
STAT4 Ensembl NCBI GeneCards UniProt	ENSG00000138378.19	STAT4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
STAT4	hg38_v1_chr2_-_191150971_191151017, hg38_v1_chr2_-_191151568_191151596	0.35	8.8e-08	Click!

Activity profile of STAT4 motif

Sorted Z-values of STAT4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT4

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Promoter	Score	Transcript	Gene	Gene Info
chr19_-_34677157 Show fit	13.71	ENST00000601241.6	SCGB2B2 Ensembl NCBI GeneCards UniProt Show fit	secretoglobin family 2B member 2
chr8_-_27611325 Show fit	12.35	ENST00000523500.5	CLU Ensembl NCBI GeneCards UniProt Show fit	clusterin
chr10_+_104269163 Show fit	11.14	ENST00000338595.7	GSTO2 Ensembl NCBI GeneCards UniProt Show fit	glutathione S-transferase omega 2
chr5_-_140633690 Show fit	10.90	ENST00000512545.1 ENST00000401743.6	CD14 Ensembl NCBI GeneCards UniProt Show fit	CD14 molecule
chr2_+_68734861 Show fit	10.86	ENST00000467265.5	ARHGAP25 Ensembl NCBI GeneCards UniProt Show fit	Rho GTPase activating protein 25
chr5_-_140633167 Show fit	10.82	ENST00000302014.11	CD14 Ensembl NCBI GeneCards UniProt Show fit	CD14 molecule
chr4_+_157220654 Show fit	10.55	ENST00000393815.6	GRIA2 Ensembl NCBI GeneCards UniProt Show fit	glutamate ionotropic receptor AMPA type subunit 2
chr4_+_157220691 Show fit	10.38	ENST00000509417.5 ENST00000645636.1 ENST00000296526.12 ENST00000264426.14	GRIA2 Ensembl NCBI GeneCards UniProt Show fit	glutamate ionotropic receptor AMPA type subunit 2
chr1_+_232950580 Show fit	10.17	ENST00000366628.10 ENST00000366627.4	NTPCR Ensembl NCBI GeneCards UniProt Show fit	nucleoside-triphosphatase, cancer-related
chr14_-_21022817 Show fit	9.94	ENST00000554104.5	NDRG2 Ensembl NCBI GeneCards UniProt Show fit	NDRG family member 2

Showing 1 to 10 of 193 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	43.6	GO:0090361	platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.5	24.4	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
4.3	21.7	GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
4.3	21.4	GO:1902847	regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.0	18.1	GO:0051056	regulation of small GTPase mediated signal transduction(GO:0051056)
0.7	13.9	GO:0006957	complement activation, alternative pathway(GO:0006957)
1.2	11.1	GO:0090487	toxin catabolic process(GO:0009407) secondary metabolite catabolic process(GO:0090487)
0.0	10.2	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
1.2	9.3	GO:0061709	reticulophagy(GO:0061709)
0.4	9.0	GO:0030277	maintenance of gastrointestinal epithelium(GO:0030277)

Showing 1 to 10 of 102 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	45.0	GO:0030426	growth cone(GO:0030426)
2.4	21.7	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
1.4	21.4	GO:0097418	neurofibrillary tangle(GO:0097418)
7.0	20.9	GO:0098843	postsynaptic endocytic zone(GO:0098843)
0.1	9.5	GO:0015030	Cajal body(GO:0015030)
0.0	9.4	GO:0072562	blood microparticle(GO:0072562)
0.5	9.3	GO:0031089	platelet dense granule lumen(GO:0031089)
0.1	9.3	GO:0005801	cis-Golgi network(GO:0005801)
0.4	8.8	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.2	7.9	GO:0034451	centriolar satellite(GO:0034451)

Showing 1 to 10 of 59 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.4	21.7	GO:0016019	peptidoglycan receptor activity(GO:0016019)
0.9	21.4	GO:0051787	misfolded protein binding(GO:0051787)
2.6	20.9	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
2.2	11.1	GO:0045174	glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
3.4	10.2	GO:0098519	nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.1	9.3	GO:0008307	structural constituent of muscle(GO:0008307)
0.5	8.6	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
1.7	8.3	GO:0004522	ribonuclease A activity(GO:0004522)
1.6	8.2	GO:0031726	CCR1 chemokine receptor binding(GO:0031726)
0.1	8.2	GO:0050681	androgen receptor binding(GO:0050681)

Showing 1 to 10 of 81 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	79.5	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.3	21.9	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.5	17.7	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.1	8.8	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.3	8.6	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.0	8.1	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	6.9	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4	4.9	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.0	4.5	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	4.3	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4

Showing 1 to 10 of 27 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	24.1	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
1.7	21.7	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.8	20.9	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1	16.4	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.1	13.0	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.1	11.9	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.3	11.1	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.2	9.4	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	7.4	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.1	6.5	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction

Showing 1 to 10 of 43 entries

Results for STAT4

Z-value: 0.81

Motif logo

Transcription factors associated with STAT4

Activity-expression correlation:

Activity profile of STAT4 motif

Sorted Z-values of STAT4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT4

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: