GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Gene | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
STAT5A | hg38_v1_chr17_+_42289213_42289327, hg38_v1_chr17_+_42288464_42288543, hg38_v1_chr17_+_42288429_42288448 | 0.50 | 6.5e-15 | Click! |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.7 | 78.4 | GO:0032731 | positive regulation of interleukin-1 beta production(GO:0032731) |
0.4 | 31.7 | GO:0045576 | mast cell activation(GO:0045576) |
10.2 | 30.7 | GO:0071461 | cellular response to redox state(GO:0071461) |
0.8 | 28.9 | GO:0035455 | response to interferon-alpha(GO:0035455) |
3.1 | 28.3 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
0.4 | 27.8 | GO:0070125 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
0.3 | 26.5 | GO:0031295 | T cell costimulation(GO:0031295) |
0.4 | 26.2 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
0.2 | 26.1 | GO:0002431 | Fc receptor mediated stimulatory signaling pathway(GO:0002431) immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) |
0.2 | 25.7 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 127.6 | GO:0016607 | nuclear speck(GO:0016607) |
0.0 | 60.0 | GO:0005654 | nucleoplasm(GO:0005654) |
0.4 | 46.9 | GO:0045335 | phagocytic vesicle(GO:0045335) |
0.6 | 36.4 | GO:0001772 | immunological synapse(GO:0001772) |
0.3 | 28.7 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
4.7 | 28.3 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
0.2 | 26.8 | GO:0001650 | fibrillar center(GO:0001650) |
1.3 | 23.8 | GO:0042613 | MHC class II protein complex(GO:0042613) |
1.1 | 23.6 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
1.1 | 21.7 | GO:0000974 | Prp19 complex(GO:0000974) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 70.7 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.2 | 39.3 | GO:0051015 | actin filament binding(GO:0051015) |
0.2 | 38.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
3.8 | 30.7 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
1.0 | 28.9 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
0.0 | 25.2 | GO:0003723 | RNA binding(GO:0003723) |
0.1 | 24.3 | GO:0042393 | histone binding(GO:0042393) |
1.7 | 23.8 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
5.7 | 22.7 | GO:0008311 | double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311) |
1.3 | 20.4 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 44.9 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
1.0 | 40.5 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
0.7 | 39.4 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
0.4 | 36.1 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
0.8 | 35.0 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
0.6 | 29.4 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
0.5 | 23.4 | PID FANCONI PATHWAY | Fanconi anemia pathway |
0.3 | 21.3 | PID PLK1 PATHWAY | PLK1 signaling events |
0.8 | 20.7 | PID IL5 PATHWAY | IL5-mediated signaling events |
0.1 | 18.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 56.9 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
0.4 | 44.0 | REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | Genes involved in Processing of Capped Intron-Containing Pre-mRNA |
0.5 | 43.7 | REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE | Genes involved in p53-Dependent G1 DNA Damage Response |
0.5 | 39.9 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
1.8 | 38.2 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
1.6 | 37.7 | REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
2.0 | 32.2 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |
0.2 | 30.0 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
0.5 | 28.5 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
0.8 | 28.1 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |