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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for STAT5B
Z-value: 1.36
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Transcription factors associated with STAT5B
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| STAT5B | hg38_v1_chr17_-_42276341_42276443 | -0.06 | 3.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of STAT5B
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 457.0 | GO:0006355 | regulation of transcription, DNA-templated(GO:0006355) |
| 14.1 | 42.4 | GO:1900195 | positive regulation of oocyte maturation(GO:1900195) negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777) |
| 8.2 | 32.8 | GO:1904749 | regulation of protein localization to nucleolus(GO:1904749) |
| 1.0 | 30.3 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
| 1.2 | 28.5 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
| 0.1 | 21.9 | GO:0048232 | spermatogenesis(GO:0007283) male gamete generation(GO:0048232) |
| 0.2 | 21.6 | GO:0042795 | snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795) |
| 1.4 | 21.5 | GO:0047484 | regulation of response to osmotic stress(GO:0047484) |
| 0.3 | 20.7 | GO:0035307 | positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307) |
| 5.1 | 20.5 | GO:1903116 | positive regulation of actin filament-based movement(GO:1903116) positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 221.7 | GO:0005634 | nucleus(GO:0005634) |
| 4.7 | 42.4 | GO:0072687 | meiotic spindle(GO:0072687) |
| 2.2 | 35.6 | GO:0030914 | STAGA complex(GO:0030914) |
| 2.0 | 32.8 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.0 | 30.6 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 1.9 | 27.1 | GO:0001741 | XY body(GO:0001741) |
| 0.2 | 21.5 | GO:0005901 | caveola(GO:0005901) |
| 4.1 | 20.5 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
| 0.2 | 20.5 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.2 | 20.4 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 339.0 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.1 | 190.5 | GO:0003677 | DNA binding(GO:0003677) |
| 14.1 | 42.4 | GO:0034739 | histone deacetylase activity (H4-K16 specific)(GO:0034739) |
| 0.0 | 35.8 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.5 | 35.5 | GO:0004402 | histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733) |
| 2.0 | 32.8 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.5 | 30.4 | GO:0030552 | cAMP binding(GO:0030552) |
| 5.5 | 27.7 | GO:0047273 | galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273) |
| 0.7 | 20.5 | GO:0050998 | nitric-oxide synthase binding(GO:0050998) |
| 0.6 | 20.3 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 42.4 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.5 | 24.8 | PID MYC PATHWAY | C-MYC pathway |
| 0.6 | 20.3 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.2 | 11.5 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 7.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 6.5 | ST ADRENERGIC | Adrenergic Pathway |
| 0.0 | 6.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 5.3 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.2 | 4.3 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.1 | 3.2 | PID IL23 PATHWAY | IL23-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 333.2 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.7 | 23.8 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.2 | 21.8 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.4 | 21.7 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.3 | 20.3 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.4 | 17.7 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.2 | 15.2 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.2 | 14.7 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.4 | 13.8 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.2 | 13.2 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |