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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for STAT6

Z-value: 0.61

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Transcription factors associated with STAT6

Gene Symbol Gene ID Gene Info
ENSG00000166888.12 STAT6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
STAT6hg38_v1_chr12_-_57129001_57129100,
hg38_v1_chr12_-_57110284_57110340
0.162.0e-02Click!

Activity profile of STAT6 motif

Sorted Z-values of STAT6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT6

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr5_-_151686908 7.46 ENST00000231061.9
secreted protein acidic and cysteine rich
chrX_+_136169624 7.33 ENST00000394153.6
four and a half LIM domains 1
chrX_+_136169833 6.11 ENST00000628032.2
four and a half LIM domains 1
chrX_-_107717054 5.82 ENST00000503515.1
ENST00000372397.6
TSC22 domain family member 3
chr4_+_165378998 5.79 ENST00000402744.9
carboxypeptidase E
chr8_-_81447428 5.50 ENST00000256103.3
ENST00000519260.1
peripheral myelin protein 2
chrX_+_136169664 5.49 ENST00000456445.5
four and a half LIM domains 1
chr11_+_73647549 5.25 ENST00000227214.10
ENST00000398494.8
ENST00000543085.5
pleckstrin homology domain containing B1
chr15_-_23687290 4.64 ENST00000649030.2
necdin, MAGE family member
chr9_+_137742957 4.49 ENST00000637318.1
ENST00000478940.1
euchromatic histone lysine methyltransferase 1
chr5_-_141958174 4.47 ENST00000231484.4
protocadherin 12
chr3_+_159069252 4.43 ENST00000640015.1
ENST00000476809.7
ENST00000485419.7
IQCJ-SCHIP1 readthrough
chr11_-_60952559 4.20 ENST00000538739.2
solute carrier family 15 member 3
chr4_+_112860981 4.16 ENST00000671704.1
ankyrin 2
chr4_+_112860912 4.06 ENST00000671951.1
ankyrin 2
chr12_-_110920710 4.00 ENST00000546404.1
myosin light chain 2
chr3_-_73624840 3.98 ENST00000308537.4
ENST00000263666.9
PDZ domain containing ring finger 3
chrX_+_136169891 3.92 ENST00000449474.5
four and a half LIM domains 1
chr11_-_60952134 3.88 ENST00000679573.1
ENST00000681882.1
ENST00000681951.1
ENST00000227880.8
solute carrier family 15 member 3
chr3_+_159273235 3.88 ENST00000638749.1
IQCJ-SCHIP1 readthrough
chr4_+_112861053 3.87 ENST00000672221.1
ankyrin 2
chr15_+_24954912 3.85 ENST00000584968.5
ENST00000346403.10
ENST00000554227.6
ENST00000390687.9
ENST00000579070.5
ENST00000577565.1
ENST00000577949.5
ENST00000338327.4
small nuclear ribonucleoprotein polypeptide N
SNRPN upstream reading frame
chr14_-_22815856 3.84 ENST00000554758.1
ENST00000397528.8
solute carrier family 7 member 7
chr16_+_30064462 3.52 ENST00000412304.6
aldolase, fructose-bisphosphate A
chr11_-_60952067 3.52 ENST00000681275.1
solute carrier family 15 member 3
chr15_+_91100194 3.47 ENST00000394232.6
synaptic vesicle glycoprotein 2B
chr14_-_24609660 3.30 ENST00000557220.6
ENST00000216338.9
ENST00000382548.4
granzyme H
chr14_-_22815801 3.23 ENST00000397532.9
solute carrier family 7 member 7
chr5_+_36608146 3.15 ENST00000381918.4
ENST00000513646.1
solute carrier family 1 member 3
chr12_-_110920568 3.14 ENST00000548438.1
ENST00000228841.15
myosin light chain 2
chr4_-_185956652 3.02 ENST00000355634.9
sorbin and SH3 domain containing 2
chr16_+_30064274 2.95 ENST00000563060.6
aldolase, fructose-bisphosphate A
chr17_-_35880350 2.93 ENST00000605140.6
ENST00000651122.1
ENST00000603197.6
C-C motif chemokine ligand 5
chr16_+_30064142 2.86 ENST00000562168.5
ENST00000569545.5
aldolase, fructose-bisphosphate A
chr13_+_52652828 2.74 ENST00000310528.9
ENST00000343788.10
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
chr17_+_42760747 2.73 ENST00000589683.5
receptor activity modifying protein 2
chr17_+_42760805 2.53 ENST00000588928.1
receptor activity modifying protein 2
chr7_-_77199808 2.51 ENST00000248598.6
fibrinogen like 2
chr5_-_147081428 2.46 ENST00000394413.7
protein phosphatase 2 regulatory subunit Bbeta
chr4_+_6693870 2.44 ENST00000296370.4
S100 calcium binding protein P
chr6_-_41286665 2.42 ENST00000589614.5
ENST00000244709.9
ENST00000334475.10
ENST00000591620.1
triggering receptor expressed on myeloid cells 1
chr11_-_72752376 2.39 ENST00000393609.8
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr2_+_68734861 2.27 ENST00000467265.5
Rho GTPase activating protein 25
chr6_-_11232658 2.21 ENST00000379433.5
ENST00000379446.10
ENST00000620854.4
neural precursor cell expressed, developmentally down-regulated 9
chr18_-_26865689 2.14 ENST00000675739.1
ENST00000383168.9
ENST00000672981.2
ENST00000578776.1
aquaporin 4
chr6_-_24877262 2.13 ENST00000378023.8
ENST00000540914.5
RHO family interacting cell polarization regulator 2
chr17_+_36103819 2.13 ENST00000615863.2
ENST00000621626.1
C-C motif chemokine ligand 4
chr2_-_174597795 2.13 ENST00000679041.1
WAS/WASL interacting protein family member 1
chr18_-_26865732 2.07 ENST00000672188.1
aquaporin 4
chr7_-_38265678 2.06 ENST00000443402.6
T cell receptor gamma constant 1
chr2_-_174597728 2.06 ENST00000409891.5
ENST00000410117.5
WAS/WASL interacting protein family member 1
chr2_-_151971750 1.96 ENST00000636598.1
calcium voltage-gated channel auxiliary subunit beta 4
chr2_+_68734773 1.90 ENST00000409202.8
Rho GTPase activating protein 25
chr9_+_87497852 1.87 ENST00000408954.8
death associated protein kinase 1
chrX_-_73214793 1.84 ENST00000373517.4
nucleosome assembly protein 1 like 2
chr2_+_113127588 1.77 ENST00000409930.4
interleukin 1 receptor antagonist
chr4_+_95051671 1.71 ENST00000440890.7
bone morphogenetic protein receptor type 1B
chr3_+_50269140 1.71 ENST00000616701.5
ENST00000433753.4
ENST00000611067.4
semaphorin 3B
chr7_-_38249572 1.67 ENST00000436911.6
T cell receptor gamma constant 2
chr5_-_147081462 1.66 ENST00000508267.5
ENST00000504198.5
protein phosphatase 2 regulatory subunit Bbeta
chr9_+_87497675 1.64 ENST00000472284.5
ENST00000469640.6
death associated protein kinase 1
chr15_+_84981981 1.62 ENST00000339708.9
phosphodiesterase 8A
chr3_+_41194741 1.60 ENST00000643541.1
ENST00000426215.5
ENST00000645210.1
ENST00000646381.1
ENST00000405570.6
ENST00000642248.1
ENST00000433400.6
catenin beta 1
chr2_-_108989206 1.58 ENST00000258443.7
ENST00000409271.5
ENST00000376651.1
ectodysplasin A receptor
chr20_-_23086316 1.57 ENST00000246006.5
CD93 molecule
chrX_-_103064164 1.56 ENST00000372728.4
brain expressed X-linked 1
chr17_+_70075215 1.55 ENST00000283936.5
ENST00000615244.4
ENST00000392671.6
potassium inwardly rectifying channel subfamily J member 16
chr11_+_112961480 1.53 ENST00000621850.4
neural cell adhesion molecule 1
chr12_-_6342066 1.51 ENST00000162749.7
ENST00000440083.6
TNF receptor superfamily member 1A
chr11_-_56292254 1.48 ENST00000641600.1
olfactory receptor family 8 subfamily H member 1
chr17_-_36534883 1.48 ENST00000620640.4
myosin XIX
chr15_-_29822418 1.48 ENST00000614355.5
ENST00000495972.6
ENST00000346128.10
tight junction protein 1
chr2_+_131011683 1.47 ENST00000355771.7
Rho guanine nucleotide exchange factor 4
chr11_+_112961402 1.47 ENST00000613217.4
ENST00000316851.12
ENST00000620046.4
ENST00000531044.5
ENST00000529356.5
neural cell adhesion molecule 1
chr5_+_7396099 1.35 ENST00000338316.9
adenylate cyclase 2
chr22_-_29061831 1.34 ENST00000216071.5
chromosome 22 open reading frame 31
chr14_-_68979314 1.33 ENST00000684713.1
ENST00000683198.1
ENST00000684598.1
ENST00000682331.1
ENST00000682291.1
ENST00000683342.1
actinin alpha 1
chr2_+_190927649 1.32 ENST00000409428.5
ENST00000409215.5
glutaminase
chr4_-_46390039 1.26 ENST00000540012.5
gamma-aminobutyric acid type A receptor subunit alpha2
chr7_+_139231225 1.22 ENST00000473989.8
ubinuclein 2
chr17_+_34255274 1.21 ENST00000580907.5
ENST00000225831.4
C-C motif chemokine ligand 2
chr9_+_87497222 1.20 ENST00000358077.9
death associated protein kinase 1
chr6_-_119149124 1.19 ENST00000368475.8
family with sequence similarity 184 member A
chr6_+_137867241 1.19 ENST00000612899.5
ENST00000420009.5
TNF alpha induced protein 3
chr3_+_141402322 1.19 ENST00000510338.5
ENST00000504673.5
zinc finger and BTB domain containing 38
chr1_-_201946469 1.14 ENST00000367288.5
leiomodin 1
chr4_-_10684749 1.06 ENST00000226951.11
cytokine dependent hematopoietic cell linker
chr15_+_64094060 1.06 ENST00000560829.5
sorting nexin 1
chr11_+_112961247 1.06 ENST00000621518.4
ENST00000618266.4
ENST00000615112.4
ENST00000615285.4
ENST00000619839.4
ENST00000401611.6
ENST00000621128.4
neural cell adhesion molecule 1
chr17_+_7558465 1.05 ENST00000349228.8
TNF superfamily member 13
chr1_+_121087343 1.04 ENST00000616817.4
ENST00000623603.3
ENST00000369384.9
ENST00000369383.8
ENST00000369178.5
Fc fragment of IgG receptor Ib
chr14_-_68979436 1.04 ENST00000193403.10
actinin alpha 1
chr16_-_67719300 1.02 ENST00000602279.2
ENST00000268797.12
ENST00000602855.2
ENST00000602377.1
glucose-fructose oxidoreductase domain containing 2
chr6_+_26440472 1.01 ENST00000494393.5
ENST00000482451.5
ENST00000471353.5
ENST00000361232.7
ENST00000487627.5
ENST00000496719.1
ENST00000244519.7
ENST00000490254.5
ENST00000487272.1
butyrophilin subfamily 3 member A3
chr12_+_8992029 1.01 ENST00000543895.1
killer cell lectin like receptor G1
chr17_+_7558258 0.98 ENST00000483039.5
ENST00000380535.8
ENST00000396542.5
TNF superfamily member 13
chr5_+_35856883 0.95 ENST00000506850.5
ENST00000303115.8
ENST00000511982.1
interleukin 7 receptor
chr15_+_84981834 0.93 ENST00000394553.6
phosphodiesterase 8A
chr9_-_133121228 0.92 ENST00000372050.8
ral guanine nucleotide dissociation stimulator
chr1_+_149782671 0.91 ENST00000444948.5
ENST00000369168.5
Fc fragment of IgG receptor Ia
chr17_+_7558712 0.91 ENST00000338784.9
ENST00000625791.2
TNF superfamily member 13
chr17_-_36534841 0.90 ENST00000614623.5
ENST00000621344.4
myosin XIX
chr1_+_150272772 0.89 ENST00000369098.3
ENST00000369099.8
chromosome 1 open reading frame 54
chr2_-_26478032 0.86 ENST00000338581.10
ENST00000402415.8
otoferlin
chr17_+_7558774 0.83 ENST00000396545.4
TNF superfamily member 13
chr14_+_38207893 0.83 ENST00000267377.3
somatostatin receptor 1
chr8_+_122781621 0.82 ENST00000314393.6
zinc fingers and homeoboxes 2
chr7_-_83649097 0.80 ENST00000643230.2
semaphorin 3E
chr4_-_46390100 0.80 ENST00000381620.9
gamma-aminobutyric acid type A receptor subunit alpha2
chr6_-_27912396 0.79 ENST00000303324.4
olfactory receptor family 2 subfamily B member 2
chr12_+_12611839 0.79 ENST00000228865.3
cAMP responsive element binding protein like 2
chr8_-_30912998 0.76 ENST00000643185.2
testis expressed 15, meiosis and synapsis associated
chr10_+_12068945 0.76 ENST00000263035.9
dehydrogenase E1 and transketolase domain containing 1
chr17_+_36211055 0.74 ENST00000617405.5
ENST00000617416.4
ENST00000613173.4
ENST00000620732.4
ENST00000620098.4
ENST00000620576.4
ENST00000620055.4
ENST00000610565.4
ENST00000620250.1
C-C motif chemokine ligand 4 like 2
chr2_+_119366924 0.72 ENST00000535757.5
ENST00000535617.5
ENST00000627093.2
ENST00000355857.8
ENST00000409094.5
ENST00000542275.5
ENST00000311521.8
diazepam binding inhibitor, acyl-CoA binding protein
chr11_-_119381629 0.69 ENST00000260187.7
ENST00000455332.6
ubiquitin specific peptidase 2
chr12_+_94262521 0.68 ENST00000545312.1
plexin C1
chr14_-_24634266 0.68 ENST00000382540.5
granzyme B
chr14_+_22052503 0.66 ENST00000390449.3
T cell receptor alpha variable 21
chr3_-_49813880 0.65 ENST00000333486.4
ubiquitin like modifier activating enzyme 7
chr1_-_153348825 0.61 ENST00000368739.3
ENST00000359650.10
peptidoglycan recognition protein 4
chr7_-_15686671 0.60 ENST00000262041.6
mesenchyme homeobox 2
chr11_+_7597182 0.60 ENST00000528883.5
PPFIA binding protein 2
chr12_+_43758936 0.59 ENST00000440781.6
ENST00000431837.5
ENST00000550616.5
ENST00000613694.5
ENST00000551736.5
interleukin 1 receptor associated kinase 4
chr20_-_18497218 0.59 ENST00000337227.9
RB binding protein 9, serine hydrolase
chrX_+_101623121 0.58 ENST00000491568.6
ENST00000479298.5
ENST00000471229.7
armadillo repeat containing X-linked 3
chr12_-_9999176 0.57 ENST00000298527.10
ENST00000348658.4
C-type lectin domain family 1 member B
chr4_+_70472189 0.55 ENST00000304887.6
mucin 7, secreted
chr7_+_32979445 0.54 ENST00000418354.5
ENST00000490776.3
FKBP prolyl isomerase 9
chr3_+_189789672 0.52 ENST00000434928.5
tumor protein p63
chr11_+_77821105 0.52 ENST00000532481.5
adipogenesis associated Mth938 domain containing
chr2_-_26478113 0.51 ENST00000339598.8
otoferlin
chr12_-_70637405 0.50 ENST00000548122.2
ENST00000551525.5
ENST00000550358.5
ENST00000334414.11
protein tyrosine phosphatase receptor type B
chr2_-_60550900 0.50 ENST00000643222.1
ENST00000643459.1
ENST00000489516.7
BAF chromatin remodeling complex subunit BCL11A
chr14_-_24634160 0.49 ENST00000616551.1
ENST00000382542.5
ENST00000216341.9
ENST00000526004.1
ENST00000415355.7
granzyme B
chr3_+_154121366 0.47 ENST00000465093.6
ENST00000496710.5
ENST00000465817.1
Rho guanine nucleotide exchange factor 26
chr8_+_96493803 0.47 ENST00000518385.5
ENST00000302190.9
syndecan 2
chr2_+_106487349 0.42 ENST00000643224.2
ENST00000416057.2
CD8b2 molecule
chr10_-_100009860 0.41 ENST00000324109.9
dynamin binding protein
chr5_-_84384871 0.40 ENST00000296591.10
EGF like repeats and discoidin domains 3
chr6_-_32853813 0.39 ENST00000643049.2
transporter 1, ATP binding cassette subfamily B member
chr6_-_41201128 0.39 ENST00000483722.2
triggering receptor expressed on myeloid cells like 2
chr19_+_15944299 0.37 ENST00000641275.1
olfactory receptor family 10 subfamily H member 4
chr6_-_32853618 0.34 ENST00000354258.5
transporter 1, ATP binding cassette subfamily B member
chr11_+_8019193 0.33 ENST00000534099.5
TUB bipartite transcription factor
chr22_-_41946729 0.32 ENST00000402420.1
centromere protein M
chr2_-_132670194 0.32 ENST00000397463.3
LY6/PLAUR domain containing 1
chr3_+_189789734 0.31 ENST00000437221.5
ENST00000392463.6
ENST00000392461.7
ENST00000449992.5
ENST00000456148.1
tumor protein p63
chr16_+_67660946 0.31 ENST00000602551.5
ENST00000219255.3
ENST00000458121.7
par-6 family cell polarity regulator alpha
chr1_-_203229660 0.31 ENST00000255427.7
ENST00000367229.6
chitinase 1
chr17_-_41350824 0.27 ENST00000007735.4
keratin 33A
chr13_+_73054969 0.25 ENST00000539231.5
Kruppel like factor 5
chr1_+_241532370 0.23 ENST00000366559.9
ENST00000366557.8
kynurenine 3-monooxygenase
chr9_-_13175824 0.22 ENST00000545857.5
multiple PDZ domain crumbs cell polarity complex component
chr4_+_159241016 0.22 ENST00000644902.1
Rap guanine nucleotide exchange factor 2
chr19_-_7702139 0.21 ENST00000346664.9
Fc fragment of IgE receptor II
chr3_+_132660305 0.17 ENST00000683741.1
ENST00000468022.5
ENST00000356232.10
ENST00000473651.5
ENST00000494238.6
ubiquitin like modifier activating enzyme 5
chr11_+_36594369 0.16 ENST00000678060.1
ENST00000446510.6
ENST00000676979.1
ENST00000677808.1
ENST00000617650.5
ENST00000334307.10
ENST00000531554.6
ENST00000679022.1
ENST00000347206.8
ENST00000534635.5
ENST00000676921.1
ENST00000678950.1
ENST00000530697.6
ENST00000527108.6
ENST00000532470.3
intraflagellar transport associated protein
chr1_-_94121105 0.14 ENST00000649773.1
ENST00000370225.4
ATP binding cassette subfamily A member 4
chr1_+_174447944 0.14 ENST00000367685.5
G protein-coupled receptor 52
chr11_-_790062 0.14 ENST00000330106.5
cell cycle exit and neuronal differentiation 1
chr15_+_67548992 0.13 ENST00000354498.9
mitogen-activated protein kinase kinase 5
chr2_-_189179754 0.13 ENST00000374866.9
ENST00000618828.1
collagen type V alpha 2 chain
chr11_+_63888515 0.12 ENST00000509502.6
ENST00000512060.1
microtubule affinity regulating kinase 2
chr17_+_36210924 0.09 ENST00000615418.4
C-C motif chemokine ligand 4 like 2
chr17_+_7558296 0.08 ENST00000438470.5
ENST00000436057.5
TNF superfamily member 13
chr1_+_45500287 0.07 ENST00000401061.9
ENST00000616135.1
metabolism of cobalamin associated C
chr19_-_7702124 0.07 ENST00000597921.6
Fc fragment of IgE receptor II
chrX_-_101291325 0.07 ENST00000356784.2
TATA-box binding protein associated factor 7 like
chr8_-_42768781 0.07 ENST00000276410.7
cholinergic receptor nicotinic alpha 6 subunit
chr6_+_31571957 0.02 ENST00000454783.5
lymphotoxin alpha
chr14_-_24081928 0.01 ENST00000396995.1
neural retina leucine zipper
chr2_-_202871433 0.00 ENST00000457524.5
ENST00000421334.1
ENST00000617388.4
islet cell autoantigen 1 like

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 12.1 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
1.2 5.8 GO:0030070 insulin processing(GO:0030070)
1.1 7.5 GO:0033591 response to L-ascorbic acid(GO:0033591)
1.0 7.1 GO:1990822 regulation of arginine metabolic process(GO:0000821) basic amino acid transmembrane transport(GO:1990822)
0.8 5.1 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.7 5.8 GO:0070235 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.6 7.1 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.6 1.2 GO:2000501 regulation of natural killer cell chemotaxis(GO:2000501)
0.6 2.4 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.5 5.3 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.5 9.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.4 4.5 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.4 2.1 GO:2001107 negative regulation of establishment of T cell polarity(GO:1903904) negative regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001107)
0.4 2.4 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
0.4 1.2 GO:0072573 negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573)
0.4 2.7 GO:0052422 modulation by symbiont of host molecular function(GO:0052055) modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.4 1.8 GO:2000035 regulation of stem cell division(GO:2000035)
0.3 4.5 GO:0060992 response to fungicide(GO:0060992)
0.3 1.6 GO:0061324 glial cell fate determination(GO:0007403) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of chromatin-mediated maintenance of transcription(GO:1904499) positive regulation of chromatin-mediated maintenance of transcription(GO:1904501) regulation of euchromatin binding(GO:1904793)
0.3 22.9 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.3 3.8 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.2 0.7 GO:0046967 cytosol to ER transport(GO:0046967)
0.2 1.7 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731)
0.2 1.8 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.2 4.7 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.2 0.6 GO:0051710 regulation of cytolysis in other organism(GO:0051710)
0.2 0.6 GO:0001757 somite specification(GO:0001757)
0.2 1.1 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.2 4.1 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.2 0.8 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.2 0.6 GO:1904674 ectoderm and mesoderm interaction(GO:0007499) positive regulation of somatic stem cell population maintenance(GO:1904674)
0.2 9.1 GO:0008038 neuron recognition(GO:0008038)
0.2 1.5 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.1 1.2 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.1 4.2 GO:0006833 water transport(GO:0006833)
0.1 1.4 GO:1904322 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.1 0.5 GO:1903860 negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173)
0.1 2.4 GO:0051639 actin filament network formation(GO:0051639)
0.1 1.6 GO:0060605 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.1 0.9 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.1 3.0 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.6 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 0.5 GO:0008218 bioluminescence(GO:0008218)
0.1 5.4 GO:0007602 phototransduction(GO:0007602)
0.1 1.1 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 5.9 GO:0007528 neuromuscular junction development(GO:0007528)
0.1 2.6 GO:1903206 negative regulation of hydrogen peroxide-induced cell death(GO:1903206)
0.1 3.3 GO:0019835 cytolysis(GO:0019835)
0.1 10.4 GO:0015992 proton transport(GO:0015992)
0.1 2.4 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.1 0.2 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.1 1.5 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.0 0.3 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.7 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.2 GO:1900377 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377) positive regulation of dendritic cell apoptotic process(GO:2000670)
0.0 0.5 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 1.7 GO:0050919 negative chemotaxis(GO:0050919)
0.0 1.5 GO:0010107 potassium ion import(GO:0010107)
0.0 6.0 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
0.0 0.3 GO:1904781 positive regulation of protein localization to centrosome(GO:1904781)
0.0 0.3 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.0 0.7 GO:0018345 protein palmitoylation(GO:0018345)
0.0 1.6 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.1 GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.0 0.1 GO:2000542 negative regulation of gastrulation(GO:2000542)
0.0 0.3 GO:0051712 regulation of killing of cells of other organism(GO:0051709) positive regulation of killing of cells of other organism(GO:0051712)
0.0 0.2 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.8 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.0 0.1 GO:0021590 cerebellum maturation(GO:0021590) cerebellar cortex maturation(GO:0021699)
0.0 0.6 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
0.0 0.2 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 4.2 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.0 1.5 GO:0046847 filopodium assembly(GO:0046847)
0.0 1.6 GO:0042116 macrophage activation(GO:0042116)
0.0 0.5 GO:0031640 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364)
0.0 2.2 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 0.3 GO:1905145 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.0 1.5 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.8 GO:0046326 positive regulation of glucose import(GO:0046326)
0.0 1.0 GO:0006968 cellular defense response(GO:0006968)
0.0 1.4 GO:0016079 synaptic vesicle exocytosis(GO:0016079)
0.0 4.6 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 0.1 GO:1901350 cell-cell signaling involved in cell-cell junction organization(GO:1901350)
0.0 0.5 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.3 GO:1903439 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.4 7.1 GO:0097512 cardiac myofibril(GO:0097512)
0.4 21.4 GO:0031430 M band(GO:0031430)
0.3 7.5 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.3 1.6 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.3 3.8 GO:0005687 U4 snRNP(GO:0005687)
0.2 2.5 GO:0005577 fibrinogen complex(GO:0005577)
0.2 2.1 GO:0060171 stereocilium membrane(GO:0060171)
0.2 0.5 GO:0097679 other organism cytoplasm(GO:0097679)
0.2 1.1 GO:0030905 retromer, tubulation complex(GO:0030905)
0.1 0.7 GO:0042825 MHC class I peptide loading complex(GO:0042824) TAP complex(GO:0042825)
0.1 2.1 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 1.7 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 2.4 GO:0005916 fascia adherens(GO:0005916)
0.1 0.8 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.1 4.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 2.4 GO:0031528 microvillus membrane(GO:0031528)
0.1 1.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 4.8 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 2.0 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 4.4 GO:0005884 actin filament(GO:0005884)
0.0 4.0 GO:0031594 neuromuscular junction(GO:0031594)
0.0 4.7 GO:0030658 transport vesicle membrane(GO:0030658)
0.0 12.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 25.3 GO:0005924 cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925)
0.0 2.4 GO:0016459 myosin complex(GO:0016459)
0.0 4.6 GO:0043204 perikaryon(GO:0043204)
0.0 10.4 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 4.4 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.2 GO:0001772 immunological synapse(GO:0001772)
0.0 5.7 GO:0043209 myelin sheath(GO:0043209)
0.0 2.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 2.1 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 0.6 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 1.5 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.8 GO:0001726 ruffle(GO:0001726)
0.0 2.4 GO:0005802 trans-Golgi network(GO:0005802)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 11.6 GO:0015333 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
1.0 5.1 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.8 9.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.7 5.3 GO:0097643 amylin receptor activity(GO:0097643)
0.6 5.8 GO:0043426 MRF binding(GO:0043426)
0.6 7.1 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.6 1.8 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.5 4.5 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.4 1.2 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.3 5.8 GO:0042043 neurexin family protein binding(GO:0042043)
0.3 7.1 GO:0032036 myosin heavy chain binding(GO:0032036)
0.3 2.4 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.3 4.2 GO:0015250 water channel activity(GO:0015250)
0.3 1.5 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.2 0.7 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.2 3.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.2 1.6 GO:0001849 complement component C1q binding(GO:0001849)
0.2 1.3 GO:0004359 glutaminase activity(GO:0004359)
0.2 12.1 GO:0030507 spectrin binding(GO:0030507)
0.2 1.1 GO:1990460 leptin receptor binding(GO:1990460)
0.2 4.2 GO:0005522 profilin binding(GO:0005522)
0.2 0.8 GO:0004994 somatostatin receptor activity(GO:0004994)
0.2 2.1 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.2 0.6 GO:0016019 peptidoglycan receptor activity(GO:0016019)
0.2 0.8 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 1.5 GO:0005549 odorant binding(GO:0005549)
0.1 1.7 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 4.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 2.4 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.1 2.5 GO:0038191 neuropilin binding(GO:0038191)
0.1 1.0 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.1 3.0 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 4.6 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 0.7 GO:0046979 peptide-transporting ATPase activity(GO:0015440) TAP2 binding(GO:0046979)
0.1 26.4 GO:0044325 ion channel binding(GO:0044325)
0.1 2.4 GO:0050786 RAGE receptor binding(GO:0050786)
0.1 0.6 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 5.5 GO:0015485 cholesterol binding(GO:0015485)
0.1 1.4 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 7.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 1.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 0.9 GO:0019864 IgG binding(GO:0019864)
0.1 1.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 2.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 3.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 0.3 GO:0019863 IgE binding(GO:0019863)
0.1 2.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 2.1 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 0.2 GO:0071566 UFM1 activating enzyme activity(GO:0071566)
0.1 1.2 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.6 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 1.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0090555 phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.0 0.3 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.6 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 4.1 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 1.1 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.7 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 2.4 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.1 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 0.3 GO:0004568 chitinase activity(GO:0004568) chitin binding(GO:0008061)
0.0 3.1 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.2 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.0 0.5 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 1.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.2 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.7 GO:0030332 cyclin binding(GO:0030332)
0.0 0.4 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 0.5 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 3.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.1 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 7.4 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 5.3 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 4.5 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 2.4 PID IL1 PATHWAY IL1-mediated signaling events
0.1 4.5 PID FGF PATHWAY FGF signaling pathway
0.1 1.4 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 8.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.7 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.1 4.1 PID ATR PATHWAY ATR signaling pathway
0.1 6.2 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.1 5.2 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 1.2 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.1 10.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 3.3 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 1.8 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 3.8 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 2.4 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 1.7 PID BMP PATHWAY BMP receptor signaling
0.0 1.1 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 4.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 6.8 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.6 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.3 4.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.3 4.7 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.3 21.8 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 5.8 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 9.3 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 7.1 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.4 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 6.3 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 6.1 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.7 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 1.5 REACTOME GABA B RECEPTOR ACTIVATION Genes involved in GABA B receptor activation
0.1 9.8 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.3 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 1.5 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 0.6 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.9 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.6 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 1.5 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 8.0 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.7 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 1.8 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 1.1 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.0 0.9 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 6.1 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 0.2 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.5 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.7 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 1.2 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 2.4 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.0 0.5 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 3.1 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 0.8 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.5 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 1.5 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis