Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for T
Z-value: 0.81
Motif logo
Transcription factors associated with T
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBXT | hg38_v1_chr6_-_166168612_166168619, hg38_v1_chr6_-_166167832_166167861, hg38_v1_chr6_-_166168700_166168727 | -0.44 | 6.9e-12 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of T
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 25.5 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 1.9 | 24.9 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 2.4 | 24.2 | GO:0045716 | positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716) |
| 0.7 | 16.1 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 3.2 | 15.8 | GO:1902896 | terminal web assembly(GO:1902896) |
| 0.8 | 14.9 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 2.5 | 14.8 | GO:0043103 | hypoxanthine salvage(GO:0043103) |
| 1.4 | 14.3 | GO:0060235 | lens induction in camera-type eye(GO:0060235) |
| 1.2 | 13.4 | GO:0021520 | spinal cord motor neuron cell fate specification(GO:0021520) |
| 4.0 | 12.1 | GO:0031550 | positive regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031550) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 21.5 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.1 | 16.5 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.7 | 16.1 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 2.6 | 15.8 | GO:1990357 | terminal web(GO:1990357) |
| 1.2 | 14.9 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 1.1 | 13.7 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 1.5 | 13.4 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 0.6 | 11.8 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.1 | 10.6 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 10.2 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 30.6 | GO:0051015 | actin filament binding(GO:0051015) |
| 8.3 | 24.9 | GO:0003974 | UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978) |
| 0.0 | 17.5 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.2 | 14.8 | GO:0016763 | transferase activity, transferring pentosyl groups(GO:0016763) |
| 0.5 | 13.7 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 3.0 | 12.1 | GO:0005169 | neurotrophin TRKB receptor binding(GO:0005169) |
| 0.5 | 11.8 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.1 | 11.8 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 3.2 | 9.7 | GO:0043035 | chromatin insulator sequence binding(GO:0043035) |
| 0.6 | 9.3 | GO:0000150 | recombinase activity(GO:0000150) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.1 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 14.4 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 9.6 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 8.8 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 8.6 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 8.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 7.2 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.1 | 5.5 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 5.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 4.9 | PID ATM PATHWAY | ATM pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 25.5 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.1 | 24.9 | REACTOME METABOLISM OF CARBOHYDRATES | Genes involved in Metabolism of carbohydrates |
| 0.3 | 17.8 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.6 | 14.8 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.5 | 9.6 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.1 | 9.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 8.8 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.1 | 8.6 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.6 | 8.4 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.8 | 8.2 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |