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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for TAF1
Z-value: 4.52
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Transcription factors associated with TAF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TAF1 | hg38_v1_chrX_+_71366290_71366368 | -0.53 | 4.9e-17 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TAF1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 1192.8 | GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 12.7 | 962.3 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 3.5 | 506.7 | GO:0045047 | protein targeting to ER(GO:0045047) |
| 7.2 | 500.9 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 18.1 | 325.8 | GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) |
| 8.2 | 319.7 | GO:0045841 | negative regulation of mitotic metaphase/anaphase transition(GO:0045841) mitotic spindle checkpoint(GO:0071174) |
| 19.5 | 312.8 | GO:0043248 | proteasome assembly(GO:0043248) |
| 4.4 | 289.1 | GO:0051439 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) |
| 3.5 | 242.3 | GO:0035722 | interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349) |
| 14.9 | 237.8 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 772.0 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 17.9 | 502.2 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 4.2 | 437.4 | GO:0015934 | large ribosomal subunit(GO:0015934) |
| 15.5 | 434.8 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 6.2 | 359.6 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 7.2 | 324.6 | GO:0000313 | organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761) |
| 33.8 | 304.1 | GO:0042382 | paraspeckles(GO:0042382) |
| 2.7 | 291.4 | GO:0005840 | ribosome(GO:0005840) |
| 0.8 | 250.6 | GO:0016607 | nuclear speck(GO:0016607) |
| 10.4 | 229.3 | GO:0071141 | SMAD protein complex(GO:0071141) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 1730.4 | GO:0003723 | RNA binding(GO:0003723) |
| 4.9 | 1051.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 7.3 | 462.5 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 8.1 | 437.0 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 6.3 | 338.5 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 6.7 | 272.7 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 9.5 | 266.9 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 3.1 | 231.1 | GO:0019003 | GDP binding(GO:0019003) |
| 4.9 | 220.1 | GO:0061650 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
| 6.1 | 206.8 | GO:0001671 | ATPase activator activity(GO:0001671) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.8 | 394.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 6.7 | 322.6 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 4.8 | 308.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 2.7 | 284.9 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 1.4 | 251.3 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 1.9 | 211.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 7.1 | 191.2 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 3.6 | 158.9 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 4.9 | 151.0 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 2.3 | 140.8 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.2 | 821.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 10.4 | 757.2 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 4.8 | 751.7 | REACTOME TRANSLATION | Genes involved in Translation |
| 5.0 | 667.0 | REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | Genes involved in Processing of Capped Intron-Containing Pre-mRNA |
| 6.4 | 470.5 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 2.8 | 416.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 7.5 | 367.4 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 5.2 | 337.7 | REACTOME SIGNAL TRANSDUCTION BY L1 | Genes involved in Signal transduction by L1 |
| 7.3 | 262.2 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 7.0 | 245.2 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |