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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for TBX15_MGA
Z-value: 1.03
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Transcription factors associated with TBX15_MGA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MGA | hg38_v1_chr15_+_41660397_41660471 | -0.03 | 6.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBX15_MGA
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 31.9 | GO:0034315 | regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315) |
| 3.0 | 21.0 | GO:0030421 | defecation(GO:0030421) |
| 1.4 | 20.2 | GO:0035826 | rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680) |
| 5.0 | 20.0 | GO:0010652 | regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652) |
| 0.3 | 18.2 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.1 | 18.2 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
| 0.5 | 16.3 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 2.6 | 15.3 | GO:0006001 | fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) |
| 1.4 | 15.3 | GO:0021740 | trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.2 | 14.8 | GO:0048208 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 36.1 | GO:0030018 | Z disc(GO:0030018) |
| 0.1 | 30.4 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 28.3 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 1.4 | 26.0 | GO:0005922 | connexon complex(GO:0005922) |
| 2.1 | 25.8 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 0.2 | 22.1 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.2 | 21.8 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.7 | 15.0 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.5 | 13.6 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.0 | 13.5 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) nuclear outer membrane-endoplasmic reticulum membrane network(GO:0042175) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 32.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.2 | 30.9 | GO:0008201 | heparin binding(GO:0008201) |
| 1.0 | 22.9 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.7 | 21.5 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 3.3 | 20.0 | GO:0086075 | gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) |
| 0.7 | 18.2 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 18.1 | GO:0003924 | GTPase activity(GO:0003924) |
| 2.5 | 15.1 | GO:0018479 | benzaldehyde dehydrogenase (NAD+) activity(GO:0018479) |
| 0.1 | 14.8 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.1 | 13.7 | GO:0008083 | growth factor activity(GO:0008083) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 28.8 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.4 | 27.1 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.4 | 25.7 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 24.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.4 | 22.3 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.3 | 21.3 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.5 | 17.7 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.5 | 13.8 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.1 | 13.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.3 | 13.1 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 46.4 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 1.4 | 26.0 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.5 | 19.4 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.5 | 18.9 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.5 | 17.7 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.4 | 17.3 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.4 | 15.3 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 1.5 | 15.1 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 1.0 | 14.0 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.5 | 12.0 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |