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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for TBX19
Z-value: 1.06
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Transcription factors associated with TBX19
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBX19 | hg38_v1_chr1_+_168280872_168280882 | -0.13 | 5.4e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBX19
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_106185387 Show fit | 20.99 |
ENST00000390605.2
|
immunoglobulin heavy variable 1-18 |
|
| chrX_+_120604084 Show fit | 19.75 |
ENST00000371317.10
|
MCTS1 re-initiation and release factor |
|
| chr16_+_84768246 Show fit | 18.96 |
ENST00000569925.1
ENST00000567526.1 |
ubiquitin specific peptidase 10 |
|
| chr6_-_36547400 Show fit | 18.74 |
ENST00000229812.8
|
serine/threonine kinase 38 |
|
| chr9_-_113410666 Show fit | 18.65 |
ENST00000374171.5
|
DNA polymerase epsilon 3, accessory subunit |
|
| chr10_-_119536533 Show fit | 18.45 |
ENST00000392865.5
|
regulator of G protein signaling 10 |
|
| chrX_+_120604199 Show fit | 16.03 |
ENST00000371315.3
|
MCTS1 re-initiation and release factor |
|
| chr15_+_41286011 Show fit | 15.76 |
ENST00000661438.1
|
novel protein |
|
| chr2_-_85409805 Show fit | 15.18 |
ENST00000449030.5
|
capping actin protein, gelsolin like |
|
| chr10_-_93482326 Show fit | 15.03 |
ENST00000359263.9
|
myoferlin |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 42.2 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 8.9 | 35.8 | GO:0002188 | translation reinitiation(GO:0002188) |
| 0.3 | 29.5 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 1.9 | 28.0 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 0.1 | 22.1 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 6.8 | 20.5 | GO:0035744 | T-helper 1 cell cytokine production(GO:0035744) |
| 0.5 | 19.0 | GO:0019985 | translesion synthesis(GO:0019985) |
| 0.6 | 18.7 | GO:0032201 | telomere maintenance via semi-conservative replication(GO:0032201) |
| 0.2 | 18.7 | GO:0043407 | negative regulation of MAP kinase activity(GO:0043407) |
| 0.9 | 18.4 | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 44.5 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.8 | 42.2 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.2 | 29.6 | GO:0005901 | caveola(GO:0005901) |
| 3.7 | 18.7 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
| 0.1 | 18.3 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.1 | 16.9 | GO:0043679 | axon terminus(GO:0043679) |
| 0.0 | 16.1 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 15.9 | GO:0005769 | early endosome(GO:0005769) |
| 1.3 | 15.2 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.2 | 15.2 | GO:0035580 | specific granule lumen(GO:0035580) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 64.9 | GO:0003823 | antigen binding(GO:0003823) |
| 0.7 | 48.6 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.7 | 42.2 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 21.6 | GO:0008134 | transcription factor binding(GO:0008134) |
| 0.0 | 21.5 | GO:0005543 | phospholipid binding(GO:0005543) |
| 0.2 | 19.0 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 1.0 | 18.7 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.6 | 18.7 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.6 | 18.4 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.1 | 15.8 | GO:0051015 | actin filament binding(GO:0051015) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 29.6 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.2 | 14.4 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.6 | 13.3 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 13.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.3 | 13.0 | PID MYC PATHWAY | C-MYC pathway |
| 0.2 | 11.6 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.0 | 11.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 11.0 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.1 | 10.7 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.1 | 9.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 24.3 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.4 | 13.3 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.5 | 11.5 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.3 | 11.0 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.5 | 10.7 | REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS | Genes involved in NRIF signals cell death from the nucleus |
| 0.2 | 7.0 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.1 | 6.8 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.3 | 6.5 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.3 | 6.4 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 6.1 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |