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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for TBX2
Z-value: 0.70
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Transcription factors associated with TBX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBX2 | hg38_v1_chr17_+_61399835_61399851 | -0.07 | 3.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 40.7 | GO:2000680 | rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680) |
| 0.4 | 14.4 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 1.2 | 12.9 | GO:1903944 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
| 2.1 | 10.7 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 0.5 | 9.9 | GO:0070914 | UV-damage excision repair(GO:0070914) |
| 0.4 | 9.8 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.1 | 9.0 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.3 | 8.8 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 2.1 | 8.4 | GO:0090096 | metanephric cap development(GO:0072185) metanephric cap morphogenesis(GO:0072186) metanephric cap mesenchymal cell proliferation involved in metanephros development(GO:0090094) regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096) |
| 0.6 | 8.3 | GO:0043983 | histone H4-K12 acetylation(GO:0043983) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 40.7 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 0.0 | 21.0 | GO:0005730 | nucleolus(GO:0005730) |
| 0.2 | 14.7 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.6 | 12.9 | GO:0097342 | ripoptosome(GO:0097342) |
| 1.3 | 11.9 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 1.7 | 11.7 | GO:0034715 | U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715) |
| 0.7 | 10.1 | GO:0070938 | contractile ring(GO:0070938) |
| 0.4 | 9.8 | GO:0032982 | myosin filament(GO:0032982) |
| 0.2 | 9.8 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 9.6 | GO:0010008 | endosome membrane(GO:0010008) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.5 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
| 0.4 | 12.9 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.0 | 11.9 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.1 | 11.8 | GO:0003823 | antigen binding(GO:0003823) |
| 0.4 | 8.8 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.0 | 8.5 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.3 | 8.4 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.1 | 8.3 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 0.0 | 8.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.4 | 7.9 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 26.8 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.2 | 11.9 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.4 | 11.5 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 9.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.4 | 8.8 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.2 | 8.0 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 7.7 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.3 | 7.4 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 7.2 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.4 | 6.8 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 28.1 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.4 | 14.0 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.4 | 11.5 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.4 | 10.6 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 1.0 | 10.4 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.7 | 10.3 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.2 | 10.1 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.6 | 9.3 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.3 | 9.3 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.2 | 9.0 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |