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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for TBX20
Z-value: 1.11
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Transcription factors associated with TBX20
Network of associatons between targets according to the STRING database.
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 32.2 | 418.6 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 1.4 | 41.5 | GO:0006465 | signal peptide processing(GO:0006465) |
| 3.0 | 18.0 | GO:0019255 | UDP-glucuronate biosynthetic process(GO:0006065) glucose 1-phosphate metabolic process(GO:0019255) |
| 0.2 | 17.0 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 1.1 | 15.8 | GO:2000680 | rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680) |
| 0.2 | 15.6 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.0 | 12.5 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 0.8 | 10.1 | GO:0043983 | histone H4-K12 acetylation(GO:0043983) |
| 0.0 | 7.7 | GO:0001649 | osteoblast differentiation(GO:0001649) |
| 1.4 | 7.2 | GO:1902896 | terminal web assembly(GO:1902896) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 59.8 | 418.6 | GO:0097451 | glial limiting end-foot(GO:0097451) |
| 5.0 | 45.3 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.4 | 17.0 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 1.3 | 15.8 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 0.5 | 15.6 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 12.5 | GO:0034774 | secretory granule lumen(GO:0034774) |
| 0.1 | 10.1 | GO:0000123 | histone acetyltransferase complex(GO:0000123) |
| 0.1 | 7.4 | GO:0005604 | basement membrane(GO:0005604) |
| 1.2 | 7.2 | GO:1990357 | terminal web(GO:1990357) |
| 0.2 | 7.0 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 426.0 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 37.8 | GO:0008236 | serine-type peptidase activity(GO:0008236) |
| 4.5 | 18.0 | GO:0003983 | UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748) |
| 0.1 | 17.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 15.6 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.1 | 12.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 7.7 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 7.2 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 7.0 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 1.5 | 6.2 | GO:0016230 | sphingomyelin phosphodiesterase activator activity(GO:0016230) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 7.4 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 7.0 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.2 | 6.2 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 5.3 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 0.9 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 45.3 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.7 | 18.0 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 15.8 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 7.4 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 7.0 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.2 | 6.2 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.3 | 6.0 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.2 | 4.6 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.1 | 3.5 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 2.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |