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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for TBX21_TBR1
Z-value: 0.76
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Transcription factors associated with TBX21_TBR1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBX21 | hg38_v1_chr17_+_47733228_47733242 | 0.52 | 2.8e-16 | Click! |
| TBR1 | hg38_v1_chr2_+_161416273_161416325 | 0.25 | 2.2e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBX21_TBR1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.4 | 27.1 | GO:0002904 | positive regulation of B cell apoptotic process(GO:0002904) |
| 0.9 | 25.8 | GO:0035428 | hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659) |
| 2.6 | 23.3 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 0.0 | 16.7 | GO:0002250 | adaptive immune response(GO:0002250) |
| 0.0 | 15.8 | GO:0006954 | inflammatory response(GO:0006954) |
| 0.1 | 12.7 | GO:0060333 | interferon-gamma-mediated signaling pathway(GO:0060333) |
| 1.5 | 12.2 | GO:0002074 | extraocular skeletal muscle development(GO:0002074) |
| 1.9 | 11.7 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
| 2.7 | 11.0 | GO:0042663 | regulation of endodermal cell fate specification(GO:0042663) |
| 1.1 | 10.8 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 23.3 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.2 | 20.9 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.1 | 15.8 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.4 | 15.3 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.1 | 14.4 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.2 | 12.3 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.0 | 12.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.4 | 11.9 | GO:0032982 | myosin filament(GO:0032982) |
| 0.1 | 11.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.4 | 10.8 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 36.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 6.9 | 27.5 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.4 | 26.2 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 1.8 | 25.8 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
| 8.5 | 25.4 | GO:0050528 | acyloxyacyl hydrolase activity(GO:0050528) |
| 0.0 | 15.0 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.6 | 12.5 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.5 | 11.9 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 2.8 | 11.3 | GO:0032184 | SUMO polymer binding(GO:0032184) |
| 0.3 | 11.3 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 24.3 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.2 | 17.2 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 15.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 14.7 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.3 | 13.0 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.2 | 12.3 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.2 | 11.9 | PID FGF PATHWAY | FGF signaling pathway |
| 0.3 | 10.9 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 10.0 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.2 | 9.5 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 28.8 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.9 | 25.4 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.2 | 20.3 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.2 | 13.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 12.0 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.7 | 11.0 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.1 | 8.7 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.4 | 7.1 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.2 | 6.1 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.2 | 6.1 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |