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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for TBX5
Z-value: 1.06
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Transcription factors associated with TBX5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBX5 | hg38_v1_chr12_-_114406133_114406150 | 0.46 | 9.1e-13 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBX5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 36.9 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 4.5 | 36.1 | GO:0070235 | regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 3.6 | 32.7 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 4.3 | 25.7 | GO:0070829 | response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829) |
| 0.2 | 21.2 | GO:0007422 | peripheral nervous system development(GO:0007422) |
| 0.9 | 20.3 | GO:0006853 | carnitine shuttle(GO:0006853) |
| 0.2 | 19.0 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 1.5 | 17.6 | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus(GO:1990416) |
| 0.4 | 17.6 | GO:0021952 | central nervous system projection neuron axonogenesis(GO:0021952) |
| 4.1 | 16.3 | GO:1905205 | positive regulation of connective tissue replacement(GO:1905205) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 34.2 | GO:0043204 | perikaryon(GO:0043204) |
| 4.1 | 32.7 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.5 | 32.2 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.2 | 29.6 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.1 | 25.4 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 2.1 | 22.9 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.2 | 21.5 | GO:0005604 | basement membrane(GO:0005604) |
| 0.4 | 17.8 | GO:0097546 | ciliary base(GO:0097546) |
| 1.1 | 17.5 | GO:0098563 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.5 | 12.4 | GO:0044295 | axonal growth cone(GO:0044295) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 52.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.6 | 38.6 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 4.0 | 36.1 | GO:0043426 | MRF binding(GO:0043426) |
| 1.3 | 34.2 | GO:0043274 | phospholipase binding(GO:0043274) |
| 4.3 | 25.7 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 2.0 | 25.6 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 4.4 | 22.2 | GO:0004095 | carnitine O-palmitoyltransferase activity(GO:0004095) |
| 0.1 | 21.5 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.2 | 18.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.4 | 17.5 | GO:0046875 | ephrin receptor binding(GO:0046875) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 32.7 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.4 | 29.1 | SIG BCR SIGNALING PATHWAY | Members of the BCR signaling pathway |
| 0.3 | 22.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 16.1 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.6 | 16.0 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.5 | 14.7 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 12.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 11.8 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.3 | 10.4 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 10.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 49.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 39.8 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 1.2 | 32.7 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.7 | 23.9 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.3 | 23.0 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.5 | 16.0 | REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA | Genes involved in G beta:gamma signalling through PI3Kgamma |
| 0.2 | 15.5 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.3 | 15.4 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.3 | 14.4 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.5 | 10.4 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |