ISMARA results: TCF12

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for TCF12_ASCL2

Z-value: 1.57

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Transcription factors associated with TCF12_ASCL2

Gene Symbol	Gene ID	Gene Info
TCF12 Ensembl NCBI GeneCards UniProt	ENSG00000140262.18	TCF12
ASCL2 Ensembl NCBI GeneCards UniProt	ENSG00000183734.5	ASCL2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TCF12	hg38_v1_chr15_+_56918763_56918832	-0.37	1.3e-08	Click!
ASCL2	hg38_v1_chr11_-_2270584_2270595	0.17	1.2e-02	Click!

Activity profile of TCF12_ASCL2 motif

Sorted Z-values of TCF12_ASCL2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF12_ASCL2

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr22_+_22899481 Show fit	44.41	ENST00000390322.2	IGLJ2 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda joining 2
chr21_-_44910630 Show fit	32.41	ENST00000320216.10 ENST00000397852.5	ITGB2 Ensembl NCBI GeneCards UniProt Show fit	integrin subunit beta 2
chr22_-_37486357 Show fit	27.22	ENST00000356998.8 ENST00000416983.7 ENST00000424765.2	MFNG Ensembl NCBI GeneCards UniProt Show fit	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr16_+_23835946 Show fit	26.83	ENST00000321728.12 ENST00000643927.1	PRKCB Ensembl NCBI GeneCards UniProt Show fit	protein kinase C beta
chr2_+_90234809 Show fit	26.66	ENST00000443397.5	IGKV3D-7 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 3D-7
chr14_-_106658251 Show fit	25.55	ENST00000454421.2	IGHV3-64 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin heavy variable 3-64
chr1_-_27635176 Show fit	23.87	ENST00000374005.8	FGR Ensembl NCBI GeneCards UniProt Show fit	FGR proto-oncogene, Src family tyrosine kinase
chr11_-_33869816 Show fit	22.94	ENST00000395833.7	LMO2 Ensembl NCBI GeneCards UniProt Show fit	LIM domain only 2
chr22_+_22922594 Show fit	22.87	ENST00000390331.3	IGLC7 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda constant 7
chr15_-_19965101 Show fit	22.36	ENST00000338912.5	IGHV1OR15-9 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin heavy variable 1/OR15-9 (non-functional)

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.4	246.8	GO:0006910	phagocytosis, recognition(GO:0006910)
2.3	217.3	GO:0006958	complement activation, classical pathway(GO:0006958)
1.3	197.7	GO:0002377	immunoglobulin production(GO:0002377)
0.9	60.7	GO:0030049	muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.9	50.5	GO:0050853	B cell receptor signaling pathway(GO:0050853)
4.6	37.1	GO:0070235	regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
12.1	36.2	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
2.1	31.4	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
4.4	30.6	GO:0045079	negative regulation of chemokine biosynthetic process(GO:0045079)
5.9	29.4	GO:0050861	positive regulation of B cell receptor signaling pathway(GO:0050861)

Showing 1 to 10 of 709 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.4	218.1	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.1	68.1	GO:0005615	extracellular space(GO:0005615)
0.3	45.8	GO:0072562	blood microparticle(GO:0072562)
0.1	40.6	GO:0016604	nuclear body(GO:0016604)
2.1	39.6	GO:0042613	MHC class II protein complex(GO:0042613)
1.4	35.8	GO:0031095	platelet dense tubular network membrane(GO:0031095)
6.5	32.4	GO:0034688	integrin alphaM-beta2 complex(GO:0034688)
0.5	29.6	GO:0015030	Cajal body(GO:0015030)
0.4	28.0	GO:0008023	transcription elongation factor complex(GO:0008023)
0.7	26.3	GO:0042629	mast cell granule(GO:0042629)

Showing 1 to 10 of 247 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	336.4	GO:0003823	antigen binding(GO:0003823)
4.4	241.4	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.1	124.1	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.3	76.0	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.2	75.2	GO:0005096	GTPase activator activity(GO:0005096)
0.1	65.1	GO:0001071	nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.8	50.3	GO:0001102	RNA polymerase II activating transcription factor binding(GO:0001102)
3.1	43.6	GO:0032395	MHC class II receptor activity(GO:0032395)
0.7	41.6	GO:0001784	phosphotyrosine binding(GO:0001784)
4.2	37.5	GO:0043426	MRF binding(GO:0043426)

Showing 1 to 10 of 463 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	114.9	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
1.0	68.5	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
2.3	50.1	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.8	47.4	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.1	46.2	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	35.3	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.6	30.8	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
1.0	30.1	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.7	26.5	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
1.0	24.7	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Showing 1 to 10 of 101 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	101.0	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
2.2	58.6	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.6	55.4	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.3	54.2	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
1.6	49.1	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.7	46.9	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.6	45.0	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.3	41.1	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels
1.4	35.5	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.5	34.7	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines

Showing 1 to 10 of 149 entries

Results for TCF12_ASCL2

Z-value: 1.57

Motif logo

Transcription factors associated with TCF12_ASCL2

Activity-expression correlation:

Activity profile of TCF12_ASCL2 motif

Sorted Z-values of TCF12_ASCL2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF12_ASCL2

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: