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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for TCF21
Z-value: 0.74
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Transcription factors associated with TCF21
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TCF21 | hg38_v1_chr6_+_133889105_133889120 | 0.19 | 4.9e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TCF21
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_10723307 Show fit | 10.58 |
ENST00000279550.11
ENST00000228251.9 |
Y-box binding protein 3 |
|
| chr17_+_47209035 Show fit | 7.72 |
ENST00000572316.5
ENST00000354968.5 ENST00000576874.5 ENST00000536623.6 |
myosin light chain 4 |
|
| chr19_-_45322867 Show fit | 7.51 |
ENST00000221476.4
|
creatine kinase, M-type |
|
| chr22_+_22922594 Show fit | 7.30 |
ENST00000390331.3
|
immunoglobulin lambda constant 7 |
|
| chr16_-_31428325 Show fit | 7.16 |
ENST00000287490.5
|
cytochrome c oxidase subunit 6A2 |
|
| chr11_-_5243644 Show fit | 5.90 |
ENST00000643122.1
|
hemoglobin subunit delta |
|
| chr9_-_33447553 Show fit | 5.65 |
ENST00000645858.1
ENST00000297991.6 |
aquaporin 3 (Gill blood group) |
|
| chr2_-_218010202 Show fit | 5.40 |
ENST00000646520.1
|
tensin 1 |
|
| chr17_+_47209338 Show fit | 5.29 |
ENST00000393450.5
|
myosin light chain 4 |
|
| chr13_-_41061373 Show fit | 5.24 |
ENST00000405737.2
|
E74 like ETS transcription factor 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 20.1 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 3.7 | 18.7 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
| 0.3 | 12.8 | GO:0002026 | regulation of the force of heart contraction(GO:0002026) |
| 1.3 | 10.6 | GO:1902219 | negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219) |
| 0.1 | 8.0 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.5 | 7.5 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.4 | 7.4 | GO:0006527 | arginine catabolic process(GO:0006527) |
| 0.4 | 7.2 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.3 | 6.6 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
| 2.1 | 6.2 | GO:0090341 | negative regulation of secretion of lysosomal enzymes(GO:0090341) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.8 | GO:0016459 | myosin complex(GO:0016459) |
| 1.3 | 18.7 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.3 | 14.8 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.2 | 11.4 | GO:0005844 | polysome(GO:0005844) |
| 0.0 | 9.7 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.6 | 9.2 | GO:0045277 | respiratory chain complex IV(GO:0045277) |
| 0.0 | 6.7 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 1.3 | 6.6 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.0 | 6.4 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.4 | 5.9 | GO:0005833 | hemoglobin complex(GO:0005833) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 23.1 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.2 | 14.8 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 2.2 | 13.0 | GO:0032038 | myosin II heavy chain binding(GO:0032038) |
| 0.1 | 11.6 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.3 | 9.2 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 7.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.9 | 7.5 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 1.1 | 7.4 | GO:0016403 | dimethylargininase activity(GO:0016403) |
| 0.6 | 6.6 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 1.6 | 6.2 | GO:0032810 | sterol response element binding(GO:0032810) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.3 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 9.4 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 9.0 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 8.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 7.7 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 5.0 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 4.9 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 4.4 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.0 | 4.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 3.8 | PID EPO PATHWAY | EPO signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 31.7 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 10.9 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 7.9 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.1 | 7.9 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.0 | 7.2 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.0 | 6.0 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.4 | 5.7 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.3 | 5.6 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.1 | 4.9 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 4.9 | REACTOME AMYLOIDS | Genes involved in Amyloids |