ISMARA results: TCF3

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for TCF3_MYOG

Z-value: 1.31

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Transcription factors associated with TCF3_MYOG

Gene Symbol	Gene ID	Gene Info
TCF3 Ensembl NCBI GeneCards UniProt	ENSG00000071564.17	TCF3
MYOG Ensembl NCBI GeneCards UniProt	ENSG00000122180.5	MYOG

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MYOG	hg38_v1_chr1_-_203086001_203086019	-0.34	2.4e-07	Click!
TCF3	hg38_v1_chr19_-_1652576_1652622	-0.04	5.8e-01	Click!

Activity profile of TCF3_MYOG motif

Sorted Z-values of TCF3_MYOG motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF3_MYOG

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Promoter	Score	Transcript	Gene	Gene Info
chr8_+_97775775 Show fit	40.23	ENST00000521545.7	LAPTM4B Ensembl NCBI GeneCards UniProt Show fit	lysosomal protein transmembrane 4 beta
chr22_+_37675629 Show fit	38.76	ENST00000215909.10	LGALS1 Ensembl NCBI GeneCards UniProt Show fit	galectin 1
chr17_+_41255384 Show fit	27.67	ENST00000394008.1	KRTAP9-9 Ensembl NCBI GeneCards UniProt Show fit	keratin associated protein 9-9
chr3_+_159852933 Show fit	24.76	ENST00000482804.1	SCHIP1 Ensembl NCBI GeneCards UniProt Show fit	schwannomin interacting protein 1
chr2_-_17800195 Show fit	22.10	ENST00000402989.5 ENST00000428868.1	SMC6 Ensembl NCBI GeneCards UniProt Show fit	structural maintenance of chromosomes 6
chr3_+_49022077 Show fit	21.38	ENST00000326925.11	NDUFAF3 Ensembl NCBI GeneCards UniProt Show fit	NADH:ubiquinone oxidoreductase complex assembly factor 3
chrX_+_150983350 Show fit	21.32	ENST00000455596.5 ENST00000448905.6	HMGB3 Ensembl NCBI GeneCards UniProt Show fit	high mobility group box 3
chr12_-_123268244 Show fit	20.91	ENST00000618072.4	CDK2AP1 Ensembl NCBI GeneCards UniProt Show fit	cyclin dependent kinase 2 associated protein 1
chr3_+_49021605 Show fit	20.73	ENST00000451378.2	NDUFAF3 Ensembl NCBI GeneCards UniProt Show fit	NADH:ubiquinone oxidoreductase complex assembly factor 3
chr12_-_123268077 Show fit	20.20	ENST00000542174.5	CDK2AP1 Ensembl NCBI GeneCards UniProt Show fit	cyclin dependent kinase 2 associated protein 1

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	76.0	GO:0010257	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
1.0	70.9	GO:0030049	muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.3	39.5	GO:0031424	keratinization(GO:0031424)
9.7	38.8	GO:0002317	plasma cell differentiation(GO:0002317)
0.3	35.9	GO:0006261	DNA-dependent DNA replication(GO:0006261)
2.5	35.6	GO:0035826	rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
0.4	34.9	GO:0032392	DNA geometric change(GO:0032392)
2.0	25.7	GO:0000722	telomere maintenance via recombination(GO:0000722)
1.4	25.4	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
6.3	25.0	GO:1900085	negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)

Showing 1 to 10 of 371 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	76.8	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.2	53.1	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.9	42.2	GO:0045095	keratin filament(GO:0045095)
0.6	40.3	GO:0032154	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1	40.1	GO:0015629	actin cytoskeleton(GO:0015629)
0.2	36.2	GO:0005795	Golgi stack(GO:0005795)
3.0	35.6	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.7	34.5	GO:0031430	M band(GO:0031430)
0.5	31.4	GO:0045171	intercellular bridge(GO:0045171)
2.1	29.8	GO:0005862	muscle thin filament tropomyosin(GO:0005862)

Showing 1 to 10 of 189 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	58.0	GO:0008307	structural constituent of muscle(GO:0008307)
1.6	46.2	GO:0000400	four-way junction DNA binding(GO:0000400)
1.3	45.7	GO:0070182	DNA polymerase binding(GO:0070182)
0.3	44.2	GO:0005178	integrin binding(GO:0005178)
1.8	41.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	40.9	GO:0005525	GTP binding(GO:0005525)
12.9	38.8	GO:0048030	disaccharide binding(GO:0048030)
0.2	29.2	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1	27.0	GO:0003729	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.5	25.5	GO:0030276	clathrin binding(GO:0030276)

Showing 1 to 10 of 268 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	36.5	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.3	35.5	ST FAS SIGNALING PATHWAY	Fas Signaling Pathway
0.3	33.4	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.4	32.7	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.2	31.1	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.4	29.7	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.3	27.3	PID E2F PATHWAY	E2F transcription factor network
1.0	26.5	PID ARF 3PATHWAY	Arf1 pathway
0.4	25.9	PID ATR PATHWAY	ATR signaling pathway
0.5	19.5	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway

Showing 1 to 10 of 54 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	67.7	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
1.0	35.9	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.8	29.0	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.3	26.3	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.3	22.5	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.7	21.6	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.6	21.2	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.6	19.3	REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	Genes involved in Activation of ATR in response to replication stress
0.5	18.2	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.8	17.8	REACTOME RNA POL III CHAIN ELONGATION	Genes involved in RNA Polymerase III Chain Elongation

Showing 1 to 10 of 100 entries

Results for TCF3_MYOG

Z-value: 1.31

Motif logo

Transcription factors associated with TCF3_MYOG

Activity-expression correlation:

Activity profile of TCF3_MYOG motif

Sorted Z-values of TCF3_MYOG motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF3_MYOG

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: