ISMARA results: TCF7

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for TCF7

Z-value: 0.72

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Transcription factors associated with TCF7

Gene Symbol	Gene ID	Gene Info
TCF7 Ensembl NCBI GeneCards UniProt	ENSG00000081059.20	TCF7

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TCF7	hg38_v1_chr5_+_134142212_134142268	0.10	1.4e-01	Click!

Activity profile of TCF7 motif

Sorted Z-values of TCF7 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF7

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr22_-_41940208 Show fit	17.52	ENST00000472374.6	CENPM Ensembl NCBI GeneCards UniProt Show fit	centromere protein M
chr2_-_150487658 Show fit	12.38	ENST00000375734.6 ENST00000263895.9 ENST00000454202.5	RND3 Ensembl NCBI GeneCards UniProt Show fit	Rho family GTPase 3
chr5_+_32531786 Show fit	11.34	ENST00000512913.5	SUB1 Ensembl NCBI GeneCards UniProt Show fit	SUB1 regulator of transcription
chr12_+_68686951 Show fit	11.14	ENST00000378905.6 ENST00000229179.9	NUP107 Ensembl NCBI GeneCards UniProt Show fit	nucleoporin 107
chr17_+_36492202 Show fit	10.22	ENST00000612494.4 ENST00000622013.1	ZNHIT3 Ensembl NCBI GeneCards UniProt Show fit	zinc finger HIT-type containing 3
chr1_+_67685342 Show fit	9.54	ENST00000617962.2	GADD45A Ensembl NCBI GeneCards UniProt Show fit	growth arrest and DNA damage inducible alpha
chr10_+_52314272 Show fit	8.82	ENST00000373970.4	DKK1 Ensembl NCBI GeneCards UniProt Show fit	dickkopf WNT signaling pathway inhibitor 1
chr12_-_49188811 Show fit	8.81	ENST00000295766.9	TUBA1A Ensembl NCBI GeneCards UniProt Show fit	tubulin alpha 1a
chr1_-_45542726 Show fit	7.97	ENST00000676549.1	PRDX1 Ensembl NCBI GeneCards UniProt Show fit	peroxiredoxin 1
chr13_+_28659100 Show fit	7.93	ENST00000460403.1 ENST00000380842.5	POMP Ensembl NCBI GeneCards UniProt Show fit	proteasome maturation protein

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	26.2	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1	17.9	GO:0030705	cytoskeleton-dependent intracellular transport(GO:0030705)
0.5	17.5	GO:0034080	chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.7	16.8	GO:1900745	positive regulation of p38MAPK cascade(GO:1900745)
0.4	13.9	GO:0019372	lipoxygenase pathway(GO:0019372)
0.8	13.2	GO:0042178	xenobiotic catabolic process(GO:0042178)
0.4	12.1	GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261)
1.9	11.1	GO:0000973	posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.7	10.5	GO:0030150	protein import into mitochondrial matrix(GO:0030150)
2.9	8.8	GO:0009996	negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) negative regulation of cell fate specification(GO:0009996)

Showing 1 to 10 of 139 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	29.7	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.1	28.2	GO:0016607	nuclear speck(GO:0016607)
0.2	19.3	GO:0000777	condensed chromosome kinetochore(GO:0000777)
0.1	15.3	GO:0048770	melanosome(GO:0042470) pigment granule(GO:0048770)
0.7	11.1	GO:0031080	nuclear pore outer ring(GO:0031080)
0.0	11.1	GO:0005925	focal adhesion(GO:0005925)
0.2	11.0	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.0	7.8	GO:0005667	transcription factor complex(GO:0005667)
0.2	7.7	GO:0005871	kinesin complex(GO:0005871)
1.9	7.6	GO:0005960	glycine cleavage complex(GO:0005960)

Showing 1 to 10 of 85 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	33.1	GO:0003735	structural constituent of ribosome(GO:0003735)
0.1	21.5	GO:0047485	protein N-terminus binding(GO:0047485)
0.0	16.6	GO:0045296	cadherin binding(GO:0045296)
3.5	13.9	GO:0102007	lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
3.3	13.2	GO:0070404	NADH binding(GO:0070404)
0.4	11.1	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.2	11.1	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.3	10.2	GO:0046966	thyroid hormone receptor binding(GO:0046966)
0.4	9.9	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1	9.2	GO:0005200	structural constituent of cytoskeleton(GO:0005200)

Showing 1 to 10 of 111 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	16.8	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.2	10.7	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.1	9.1	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.3	8.8	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.5	8.6	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.2	8.3	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.1	7.9	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.2	7.6	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.1	7.6	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.1	6.5	ST B CELL ANTIGEN RECEPTOR	B Cell Antigen Receptor

Showing 1 to 10 of 35 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	33.1	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.6	19.3	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.2	17.5	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.1	13.3	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.2	12.3	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.1	12.2	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.3	11.1	REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.4	9.9	REACTOME KINESINS	Genes involved in Kinesins
0.2	9.9	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.2	8.5	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity

Showing 1 to 10 of 64 entries

Results for TCF7

Z-value: 0.72

Motif logo

Transcription factors associated with TCF7

Activity-expression correlation:

Activity profile of TCF7 motif

Sorted Z-values of TCF7 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF7

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: