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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for TCF7L1
Z-value: 0.85
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Transcription factors associated with TCF7L1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TCF7L1 | hg38_v1_chr2_+_85133376_85133474 | 0.02 | 7.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TCF7L1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_106975452 Show fit | 14.70 |
ENST00000619869.1
ENST00000619133.4 |
CD24 molecule |
|
| chr6_-_106975309 Show fit | 14.70 |
ENST00000615659.1
|
CD24 molecule |
|
| chr1_-_153550083 Show fit | 12.28 |
ENST00000368714.1
|
S100 calcium binding protein A4 |
|
| chr14_+_75280078 Show fit | 11.07 |
ENST00000555347.1
|
Fos proto-oncogene, AP-1 transcription factor subunit |
|
| chr6_-_106974721 Show fit | 10.86 |
ENST00000606017.2
ENST00000620405.1 |
CD24 molecule |
|
| chr18_+_3450036 Show fit | 10.66 |
ENST00000546979.5
ENST00000343820.10 ENST00000551402.1 ENST00000577543.5 |
TGFB induced factor homeobox 1 |
|
| chr18_+_3449817 Show fit | 10.56 |
ENST00000407501.6
|
TGFB induced factor homeobox 1 |
|
| chr14_-_22982258 Show fit | 9.57 |
ENST00000555074.1
ENST00000361265.8 |
novel protein ajuba LIM protein |
|
| chr21_-_44910630 Show fit | 9.32 |
ENST00000320216.10
ENST00000397852.5 |
integrin subunit beta 2 |
|
| chr7_+_80602150 Show fit | 8.77 |
ENST00000309881.11
|
CD36 molecule |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.3 | 45.1 | GO:0033606 | B cell receptor transport within lipid bilayer(GO:0032595) B cell receptor transport into membrane raft(GO:0032597) protein transport out of membrane raft(GO:0032599) chemokine receptor transport out of membrane raft(GO:0032600) negative regulation of transforming growth factor beta3 production(GO:0032913) chemokine receptor transport within lipid bilayer(GO:0033606) |
| 3.3 | 29.3 | GO:2000332 | response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
| 1.2 | 21.2 | GO:0017121 | phospholipid scrambling(GO:0017121) |
| 0.2 | 18.0 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.4 | 17.1 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
| 0.2 | 17.1 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 4.0 | 15.9 | GO:1902544 | regulation of DNA N-glycosylase activity(GO:1902544) |
| 0.0 | 15.7 | GO:0042493 | response to drug(GO:0042493) |
| 0.1 | 14.7 | GO:0006261 | DNA-dependent DNA replication(GO:0006261) |
| 0.1 | 12.3 | GO:0001837 | epithelial to mesenchymal transition(GO:0001837) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 45.1 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.9 | 34.0 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.2 | 18.0 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 17.1 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 16.5 | GO:0016605 | PML body(GO:0016605) |
| 4.7 | 14.0 | GO:0008623 | CHRAC(GO:0008623) |
| 0.4 | 13.3 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 12.6 | GO:0005667 | transcription factor complex(GO:0005667) |
| 1.4 | 11.1 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.0 | 9.7 | GO:0005925 | focal adhesion(GO:0005925) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 45.5 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 3.7 | 29.3 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 1.3 | 21.2 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.7 | 21.2 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.1 | 18.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.9 | 17.1 | GO:0015037 | peptide disulfide oxidoreductase activity(GO:0015037) |
| 5.3 | 15.9 | GO:0043739 | G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739) |
| 0.1 | 14.1 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.2 | 13.5 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.1 | 13.1 | GO:0001047 | core promoter binding(GO:0001047) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 21.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.4 | 15.1 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 14.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 14.1 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.5 | 11.1 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 11.1 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.1 | 10.0 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.4 | 9.6 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 8.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 6.5 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 32.7 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.3 | 29.3 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.4 | 21.2 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 1.0 | 19.1 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.1 | 18.0 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 15.6 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.4 | 11.1 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 9.3 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.2 | 7.3 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.2 | 6.8 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |