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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for TEAD3_TEAD1
Z-value: 2.66
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Transcription factors associated with TEAD3_TEAD1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TEAD3 | hg38_v1_chr6_-_35497042_35497117 | 0.52 | 1.0e-16 | Click! |
| TEAD1 | hg38_v1_chr11_+_12674397_12674442 | 0.47 | 1.5e-13 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TEAD3_TEAD1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_131951364 Show fit | 203.18 |
ENST00000367976.4
|
cellular communication network factor 2 |
|
| chr10_-_88952763 Show fit | 100.60 |
ENST00000224784.10
|
actin alpha 2, smooth muscle |
|
| chr7_+_116525524 Show fit | 90.10 |
ENST00000405348.6
|
caveolin 1 |
|
| chr1_+_85580751 Show fit | 87.95 |
ENST00000451137.7
|
cellular communication network factor 1 |
|
| chr7_+_116525028 Show fit | 82.67 |
ENST00000341049.7
|
caveolin 1 |
|
| chr15_+_63042632 Show fit | 69.76 |
ENST00000288398.10
ENST00000358278.7 ENST00000610733.1 ENST00000403994.9 ENST00000357980.9 ENST00000559556.5 ENST00000267996.11 ENST00000559397.6 ENST00000561266.6 ENST00000560970.6 |
tropomyosin 1 |
|
| chr7_+_116524984 Show fit | 67.62 |
ENST00000614113.5
ENST00000393470.1 |
caveolin 1 |
|
| chr5_-_39424966 Show fit | 60.57 |
ENST00000515700.5
ENST00000320816.11 ENST00000339788.10 |
DAB adaptor protein 2 |
|
| chr7_+_134779663 Show fit | 58.93 |
ENST00000361901.6
|
caldesmon 1 |
|
| chr7_+_134779625 Show fit | 58.06 |
ENST00000454108.5
ENST00000361675.7 |
caldesmon 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 60.1 | 240.4 | GO:1903609 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
| 3.4 | 161.7 | GO:0035329 | hippo signaling(GO:0035329) |
| 1.1 | 122.0 | GO:0070527 | platelet aggregation(GO:0070527) |
| 0.2 | 111.4 | GO:0006936 | muscle contraction(GO:0006936) |
| 21.7 | 108.4 | GO:0090131 | mesenchyme migration(GO:0090131) |
| 30.9 | 92.6 | GO:0035026 | leading edge cell differentiation(GO:0035026) |
| 0.7 | 74.1 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 14.0 | 69.8 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
| 6.3 | 69.8 | GO:0021730 | trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 2.7 | 60.3 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 244.0 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 14.0 | 238.0 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 8.5 | 127.5 | GO:0030478 | actin cap(GO:0030478) |
| 2.8 | 112.5 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 33.5 | 100.6 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 15.4 | 92.6 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 7.7 | 92.4 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.6 | 90.0 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.3 | 88.1 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.4 | 83.2 | GO:0030027 | lamellipodium(GO:0030027) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 60.1 | 240.4 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
| 5.5 | 148.9 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 1.3 | 127.9 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 4.8 | 99.8 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 4.3 | 98.3 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.1 | 83.4 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.7 | 67.7 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.2 | 67.2 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 2.5 | 63.7 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 14.1 | 56.3 | GO:0042134 | rRNA primary transcript binding(GO:0042134) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.5 | 241.3 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 2.4 | 167.5 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 1.5 | 117.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.6 | 116.8 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 1.2 | 111.9 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 1.4 | 111.7 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.3 | 57.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.6 | 50.7 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.8 | 47.0 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.6 | 43.4 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.4 | 405.9 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 7.7 | 269.5 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 4.1 | 110.5 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 4.6 | 97.5 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 2.6 | 62.2 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 1.8 | 60.8 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 4.4 | 47.9 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 2.7 | 42.5 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.4 | 41.7 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.3 | 36.3 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |