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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for TEAD4
Z-value: 1.14
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Transcription factors associated with TEAD4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TEAD4 | hg38_v1_chr12_+_2959870_2959953, hg38_v1_chr12_+_2959296_2959431 | -0.60 | 6.0e-23 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TEAD4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 54.2 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.4 | 35.9 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.2 | 32.4 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.5 | 31.9 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.2 | 23.8 | GO:1990823 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.3 | 20.6 | GO:0050771 | negative regulation of axonogenesis(GO:0050771) |
| 0.2 | 19.7 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 1.9 | 19.1 | GO:0090292 | nuclear matrix anchoring at nuclear membrane(GO:0090292) |
| 0.1 | 17.2 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 2.0 | 16.3 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 54.2 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 47.2 | GO:0005886 | plasma membrane(GO:0005886) |
| 0.1 | 44.5 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.1 | 42.1 | GO:0009986 | cell surface(GO:0009986) |
| 0.6 | 31.9 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.3 | 29.0 | GO:0044291 | cell-cell contact zone(GO:0044291) |
| 0.1 | 25.5 | GO:0030426 | growth cone(GO:0030426) |
| 0.5 | 21.8 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.1 | 21.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 1.5 | 19.1 | GO:0034992 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 54.2 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.3 | 47.7 | GO:0003823 | antigen binding(GO:0003823) |
| 0.4 | 35.9 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.5 | 31.9 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.3 | 29.6 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.6 | 24.4 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.2 | 23.3 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.1 | 22.8 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.6 | 19.1 | GO:0005521 | lamin binding(GO:0005521) |
| 0.1 | 17.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 54.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 23.8 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.2 | 18.1 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.2 | 13.4 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.4 | 13.2 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.1 | 13.2 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 12.3 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.5 | 12.2 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.3 | 12.2 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.2 | 11.9 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 54.2 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.4 | 35.9 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.3 | 31.9 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.4 | 19.1 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.4 | 19.0 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.2 | 18.6 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.3 | 14.0 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.3 | 13.6 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 0.1 | 12.8 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 1.7 | 12.2 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |