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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for TFAP2B
Z-value: 1.22
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Transcription factors associated with TFAP2B
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TFAP2B | hg38_v1_chr6_+_50818857_50818877 | 0.27 | 6.5e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TFAP2B
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 40.5 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 26.2 | GO:0042119 | neutrophil activation involved in immune response(GO:0002283) neutrophil activation(GO:0042119) neutrophil degranulation(GO:0043312) |
| 1.9 | 24.2 | GO:2001199 | negative regulation of dendritic cell differentiation(GO:2001199) |
| 1.8 | 23.4 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 5.0 | 19.8 | GO:0042663 | regulation of endodermal cell fate specification(GO:0042663) |
| 3.5 | 17.4 | GO:1904501 | glial cell fate determination(GO:0007403) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of chromatin-mediated maintenance of transcription(GO:1904499) positive regulation of chromatin-mediated maintenance of transcription(GO:1904501) regulation of euchromatin binding(GO:1904793) |
| 0.3 | 15.1 | GO:0034314 | Arp2/3 complex-mediated actin nucleation(GO:0034314) |
| 4.7 | 14.2 | GO:0046586 | regulation of calcium-dependent cell-cell adhesion(GO:0046586) |
| 0.9 | 13.3 | GO:1901978 | positive regulation of cell cycle checkpoint(GO:1901978) |
| 0.4 | 12.5 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 51.0 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.4 | 38.1 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.3 | 37.5 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.9 | 23.4 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 7.4 | 22.2 | GO:0036284 | tubulobulbar complex(GO:0036284) |
| 0.0 | 21.4 | GO:0005667 | transcription factor complex(GO:0005667) |
| 2.9 | 17.4 | GO:0034750 | Scrib-APC-beta-catenin complex(GO:0034750) |
| 0.2 | 16.2 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 1.4 | 15.5 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.1 | 14.7 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 42.8 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.2 | 33.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 27.8 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 1.3 | 24.5 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 1.1 | 23.4 | GO:0008494 | translation activator activity(GO:0008494) |
| 1.3 | 19.8 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 16.8 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.1 | 16.5 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.5 | 15.9 | GO:0004467 | long-chain fatty acid-CoA ligase activity(GO:0004467) |
| 0.4 | 14.4 | GO:0042605 | peptide antigen binding(GO:0042605) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 29.5 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.3 | 26.1 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 24.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 23.6 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.6 | 20.9 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.1 | 19.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 15.1 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.3 | 13.9 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.2 | 11.9 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 11.2 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 39.1 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 1.2 | 32.3 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 0.7 | 23.4 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.8 | 17.4 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.2 | 12.4 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.3 | 12.3 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.3 | 10.6 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.1 | 10.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.3 | 10.0 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.8 | 9.8 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |