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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for TFAP2E
Z-value: 0.66
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Transcription factors associated with TFAP2E
Network of associatons between targets according to the STRING database.
First level regulatory network of TFAP2E
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.8 | 22.6 | GO:0070829 | response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829) |
| 1.7 | 13.6 | GO:0050882 | voluntary musculoskeletal movement(GO:0050882) |
| 0.8 | 12.5 | GO:0070777 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.2 | 11.1 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.0 | 10.5 | GO:0007050 | cell cycle arrest(GO:0007050) |
| 0.5 | 10.1 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
| 2.9 | 8.8 | GO:2000296 | lysosomal membrane organization(GO:0097212) negative regulation of hydrogen peroxide catabolic process(GO:2000296) regulation of oxygen metabolic process(GO:2000374) |
| 1.7 | 8.3 | GO:0071233 | cellular response to leucine(GO:0071233) |
| 0.0 | 6.2 | GO:0018108 | peptidyl-tyrosine phosphorylation(GO:0018108) |
| 0.9 | 5.5 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 13.6 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.1 | 12.7 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.3 | 12.5 | GO:0030673 | axolemma(GO:0030673) |
| 2.8 | 11.1 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 1.1 | 8.8 | GO:0097450 | astrocyte end-foot(GO:0097450) |
| 0.2 | 6.5 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 1.1 | 5.7 | GO:0005854 | nascent polypeptide-associated complex(GO:0005854) |
| 0.0 | 5.3 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 5.1 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.1 | 5.0 | GO:0005930 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.8 | 22.6 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 1.7 | 13.6 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
| 0.9 | 12.5 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.1 | 11.5 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 2.8 | 11.1 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.7 | 8.8 | GO:0046870 | cadmium ion binding(GO:0046870) |
| 1.4 | 8.3 | GO:0070728 | leucine binding(GO:0070728) |
| 0.2 | 6.7 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.2 | 5.5 | GO:0031434 | mitogen-activated protein kinase kinase binding(GO:0031434) |
| 0.2 | 5.1 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 14.0 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.3 | 5.5 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 4.8 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.1 | 4.1 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 3.3 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 3.3 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 3.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 2.6 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.2 | 2.4 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 22.6 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.2 | 12.7 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.2 | 12.5 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.6 | 11.1 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.1 | 6.6 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.2 | 5.5 | REACTOME SIGNALLING TO P38 VIA RIT AND RIN | Genes involved in Signalling to p38 via RIT and RIN |
| 0.2 | 5.3 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 5.2 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.3 | 4.9 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.3 | 4.6 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |