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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for TFAP4_MSC
Z-value: 1.13
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Transcription factors associated with TFAP4_MSC
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TFAP4 | hg38_v1_chr16_-_4273014_4273065 | 0.01 | 8.5e-01 | Click! |
| MSC | hg38_v1_chr8_-_71844402_71844429 | -0.00 | 9.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TFAP4_MSC
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 64.7 | GO:0006261 | DNA-dependent DNA replication(GO:0006261) |
| 4.9 | 43.8 | GO:0070315 | G1 to G0 transition involved in cell differentiation(GO:0070315) |
| 0.5 | 38.6 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 1.6 | 27.8 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.8 | 26.2 | GO:0090383 | phagosome acidification(GO:0090383) |
| 3.5 | 21.2 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 2.2 | 19.4 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 3.2 | 19.2 | GO:0014005 | microglia differentiation(GO:0014004) microglia development(GO:0014005) collateral sprouting in absence of injury(GO:0048669) smooth endoplasmic reticulum calcium ion homeostasis(GO:0051563) cellular response to norepinephrine stimulus(GO:0071874) |
| 1.9 | 19.2 | GO:0036309 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.9 | 18.9 | GO:0034389 | lipid particle organization(GO:0034389) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 81.6 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.6 | 59.5 | GO:0030315 | T-tubule(GO:0030315) |
| 0.1 | 37.5 | GO:0031965 | nuclear membrane(GO:0031965) |
| 1.7 | 27.2 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.9 | 26.5 | GO:0033176 | proton-transporting V-type ATPase complex(GO:0033176) |
| 3.6 | 21.4 | GO:0033269 | internode region of axon(GO:0033269) |
| 2.1 | 21.2 | GO:0045180 | basal cortex(GO:0045180) |
| 0.5 | 21.2 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.0 | 20.6 | GO:0019866 | organelle inner membrane(GO:0019866) |
| 2.1 | 19.2 | GO:1990761 | growth cone lamellipodium(GO:1990761) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 70.5 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 2.3 | 50.2 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 2.6 | 43.4 | GO:0031432 | titin binding(GO:0031432) |
| 0.7 | 39.5 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.9 | 27.0 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.9 | 24.5 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 21.0 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.3 | 19.7 | GO:0030507 | spectrin binding(GO:0030507) |
| 3.2 | 19.4 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 1.8 | 18.2 | GO:0051425 | PTB domain binding(GO:0051425) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 86.8 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.3 | 21.3 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.4 | 19.7 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.4 | 14.6 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.3 | 11.8 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.2 | 9.3 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.2 | 7.9 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.2 | 7.4 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 6.9 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.1 | 6.5 | PID RHOA PATHWAY | RhoA signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 26.2 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.1 | 22.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.1 | 19.2 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.4 | 16.8 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 1.3 | 15.5 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.1 | 14.7 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.5 | 14.2 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.2 | 12.3 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.6 | 10.8 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.1 | 10.0 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |