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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for TFCP2
Z-value: 1.02
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Transcription factors associated with TFCP2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TFCP2 | hg38_v1_chr12_-_51172779_51172912 | 0.19 | 4.8e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TFCP2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr21_-_39349048 Show fit | 28.18 |
ENST00000380748.5
ENST00000380749.10 |
high mobility group nucleosome binding domain 1 |
|
| chr2_-_61538180 Show fit | 21.31 |
ENST00000677150.1
ENST00000678182.1 ENST00000677928.1 ENST00000406957.5 |
exportin 1 |
|
| chr2_-_61538313 Show fit | 20.83 |
ENST00000677803.1
ENST00000677239.1 ENST00000401558.7 |
exportin 1 |
|
| chr2_-_61538290 Show fit | 20.20 |
ENST00000678790.1
|
exportin 1 |
|
| chr4_-_173334385 Show fit | 19.91 |
ENST00000446922.6
|
high mobility group box 2 |
|
| chr4_-_173334249 Show fit | 19.08 |
ENST00000506267.1
ENST00000296503.10 |
high mobility group box 2 |
|
| chr2_-_61538516 Show fit | 16.82 |
ENST00000676771.1
ENST00000677814.1 ENST00000443240.5 ENST00000677556.1 ENST00000676553.1 |
exportin 1 |
|
| chr14_+_93185304 Show fit | 16.77 |
ENST00000415050.3
|
transmembrane protein 251 |
|
| chrX_+_119468436 Show fit | 15.93 |
ENST00000317881.9
|
solute carrier family 25 member 5 |
|
| chr2_-_89160329 Show fit | 15.16 |
ENST00000390256.2
|
immunoglobulin kappa variable 6-21 (non-functional) |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.7 | 84.2 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 0.3 | 49.6 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 3.2 | 39.0 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
| 0.4 | 30.0 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 1.4 | 28.3 | GO:0006527 | arginine catabolic process(GO:0006527) |
| 0.7 | 24.9 | GO:0032786 | positive regulation of DNA-templated transcription, elongation(GO:0032786) |
| 1.4 | 24.0 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
| 1.7 | 23.8 | GO:0001522 | pseudouridine synthesis(GO:0001522) |
| 2.8 | 19.9 | GO:0030421 | defecation(GO:0030421) |
| 0.2 | 18.8 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.9 | 79.2 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.6 | 36.7 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.2 | 31.7 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.1 | 31.6 | GO:0000785 | chromatin(GO:0000785) |
| 0.6 | 30.0 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 28.9 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.2 | 25.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 4.0 | 15.9 | GO:0071817 | MMXD complex(GO:0071817) |
| 0.0 | 15.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 2.2 | 15.2 | GO:0031415 | NatA complex(GO:0031415) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.3 | 79.2 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.3 | 52.3 | GO:0003823 | antigen binding(GO:0003823) |
| 0.8 | 40.8 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 9.7 | 39.0 | GO:0044378 | non-sequence-specific DNA binding, bending(GO:0044378) |
| 0.5 | 30.0 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 4.0 | 28.3 | GO:0016403 | dimethylargininase activity(GO:0016403) |
| 2.0 | 23.8 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.3 | 21.1 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 19.9 | GO:0008083 | growth factor activity(GO:0008083) |
| 4.0 | 15.9 | GO:0015207 | ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 79.2 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.5 | 32.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.3 | 21.1 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 13.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.6 | 11.4 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 10.9 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.2 | 9.0 | PID ATR PATHWAY | ATR signaling pathway |
| 0.2 | 8.6 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 8.6 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 8.3 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 79.2 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 2.6 | 39.0 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 1.3 | 36.7 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.6 | 27.3 | REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |
| 0.2 | 25.6 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.5 | 16.3 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.6 | 15.2 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.2 | 11.4 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.4 | 10.9 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.5 | 8.4 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |