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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for TFCP2L1
Z-value: 0.77
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Transcription factors associated with TFCP2L1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TFCP2L1 | hg38_v1_chr2_-_121285194_121285209 | 0.25 | 1.7e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TFCP2L1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.6 | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter(GO:0000122) |
| 0.5 | 9.7 | GO:0097186 | amelogenesis(GO:0097186) |
| 0.4 | 8.8 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.5 | 7.9 | GO:0060174 | limb bud formation(GO:0060174) |
| 1.1 | 5.4 | GO:0044375 | regulation of peroxisome size(GO:0044375) |
| 0.2 | 5.4 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.0 | 5.3 | GO:0002433 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) |
| 0.0 | 5.3 | GO:0002576 | platelet degranulation(GO:0002576) |
| 0.0 | 5.1 | GO:0043401 | steroid hormone mediated signaling pathway(GO:0043401) |
| 0.8 | 4.7 | GO:0010734 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 23.4 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.3 | 8.8 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.5 | 6.8 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.0 | 6.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 5.8 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 5.6 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.2 | 5.4 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.1 | 5.2 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.0 | 5.1 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.2 | 4.9 | GO:0016580 | Sin3 complex(GO:0016580) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.4 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 2.8 | 11.2 | GO:0032184 | SUMO polymer binding(GO:0032184) |
| 1.6 | 9.7 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
| 0.3 | 8.8 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.5 | 8.7 | GO:0019864 | IgG binding(GO:0019864) |
| 0.0 | 7.4 | GO:0005509 | calcium ion binding(GO:0005509) |
| 1.0 | 6.8 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.5 | 5.2 | GO:0005237 | inhibitory extracellular ligand-gated ion channel activity(GO:0005237) |
| 0.3 | 4.9 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.1 | 4.9 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.9 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 7.1 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 6.8 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 6.6 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 5.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 5.5 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 5.0 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 3.6 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 3.1 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 2.9 | PID NOTCH PATHWAY | Notch signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 33.7 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 10.4 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.3 | 8.8 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 6.9 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 5.6 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.1 | 5.5 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 5.3 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 5.2 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 5.0 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.1 | 4.0 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |