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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for TFDP1
Z-value: 2.24
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Transcription factors associated with TFDP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TFDP1 | hg38_v1_chr13_+_113584683_113584762 | 0.71 | 3.3e-35 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TFDP1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 24.3 | 339.9 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 1.6 | 278.3 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 1.8 | 151.0 | GO:0071349 | interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349) |
| 15.4 | 138.7 | GO:0006265 | DNA topological change(GO:0006265) |
| 4.8 | 138.3 | GO:0006337 | nucleosome disassembly(GO:0006337) |
| 3.3 | 131.3 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 2.6 | 130.7 | GO:0070911 | global genome nucleotide-excision repair(GO:0070911) |
| 12.5 | 124.8 | GO:0060136 | enucleate erythrocyte differentiation(GO:0043353) embryonic process involved in female pregnancy(GO:0060136) |
| 21.0 | 104.8 | GO:0006344 | optic cup formation involved in camera-type eye development(GO:0003408) maintenance of chromatin silencing(GO:0006344) |
| 24.2 | 96.9 | GO:0002270 | plasmacytoid dendritic cell activation(GO:0002270) regulation of restriction endodeoxyribonuclease activity(GO:0032072) negative regulation of apoptotic cell clearance(GO:2000426) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 385.5 | GO:0016607 | nuclear speck(GO:0016607) |
| 1.7 | 339.5 | GO:0000793 | condensed chromosome(GO:0000793) |
| 2.3 | 335.7 | GO:0016605 | PML body(GO:0016605) |
| 26.0 | 286.3 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
| 5.6 | 258.7 | GO:0090544 | BAF-type complex(GO:0090544) |
| 1.5 | 189.0 | GO:0016363 | nuclear matrix(GO:0016363) |
| 8.2 | 188.6 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 1.6 | 162.8 | GO:0005811 | lipid particle(GO:0005811) |
| 8.0 | 127.7 | GO:0005642 | annulate lamellae(GO:0005642) |
| 2.2 | 116.4 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.9 | 268.8 | GO:0008143 | poly(A) binding(GO:0008143) |
| 1.8 | 231.7 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 1.8 | 196.9 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.9 | 192.4 | GO:0051015 | actin filament binding(GO:0051015) |
| 4.2 | 172.2 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 3.8 | 172.2 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
| 3.0 | 170.4 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 8.5 | 143.9 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 3.6 | 142.3 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 2.4 | 135.8 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 293.2 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 2.6 | 265.9 | PID E2F PATHWAY | E2F transcription factor network |
| 4.2 | 198.5 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 4.1 | 144.6 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 1.8 | 141.8 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 3.1 | 123.8 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 1.2 | 114.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 1.5 | 110.3 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 2.1 | 107.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 1.9 | 98.9 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 390.1 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 14.7 | 220.4 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 5.5 | 158.3 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 4.6 | 146.3 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 2.5 | 132.5 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 5.5 | 127.3 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 3.3 | 120.3 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.8 | 115.1 | REACTOME DIABETES PATHWAYS | Genes involved in Diabetes pathways |
| 3.1 | 112.5 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 2.7 | 106.0 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |