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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for TFEC_MITF_ARNTL_BHLHE41
Z-value: 0.97
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Transcription factors associated with TFEC_MITF_ARNTL_BHLHE41
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ARNTL | hg38_v1_chr11_+_13277639_13277877 | -0.47 | 1.4e-13 | Click! |
| TFEC | hg38_v1_chr7_-_116030750_116030813, hg38_v1_chr7_-_116030735_116030746, hg38_v1_chr7_-_115968302_115968319 | -0.22 | 1.1e-03 | Click! |
| MITF | hg38_v1_chr3_+_69936583_69936600, hg38_v1_chr3_+_69866217_69866230, hg38_v1_chr3_+_69739425_69739543, hg38_v1_chr3_+_69763726_69763811, hg38_v1_chr3_+_69763549_69763560 | 0.20 | 3.0e-03 | Click! |
| BHLHE41 | hg38_v1_chr12_-_26125023_26125047 | -0.09 | 1.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TFEC_MITF_ARNTL_BHLHE41
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_57752265 Show fit | 59.93 |
ENST00000547281.5
ENST00000257904.11 ENST00000546489.5 ENST00000552388.1 |
cyclin dependent kinase 4 |
|
| chr12_-_57752345 Show fit | 56.83 |
ENST00000551800.5
ENST00000549606.5 ENST00000312990.10 |
cyclin dependent kinase 4 |
|
| chr1_-_25906457 Show fit | 36.06 |
ENST00000426559.6
|
stathmin 1 |
|
| chr1_-_25906931 Show fit | 32.76 |
ENST00000357865.6
|
stathmin 1 |
|
| chrX_-_101407893 Show fit | 27.77 |
ENST00000676156.1
ENST00000675592.1 ENST00000674634.2 ENST00000649178.1 ENST00000218516.4 |
galactosidase alpha |
|
| chr6_-_109382397 Show fit | 26.13 |
ENST00000512821.5
|
CD164 molecule |
|
| chr10_+_69124152 Show fit | 25.81 |
ENST00000395098.5
ENST00000263559.11 |
VPS26, retromer complex component A |
|
| chr6_+_159969070 Show fit | 24.55 |
ENST00000356956.6
|
insulin like growth factor 2 receptor |
|
| chr12_-_2877113 Show fit | 24.50 |
ENST00000627656.2
ENST00000359843.8 |
forkhead box M1 |
|
| chr12_-_2876986 Show fit | 24.42 |
ENST00000342628.6
ENST00000361953.7 |
forkhead box M1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 23.2 | 116.2 | GO:1904636 | response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637) |
| 3.3 | 113.4 | GO:0090383 | phagosome acidification(GO:0090383) |
| 8.5 | 101.8 | GO:0070495 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 1.4 | 81.6 | GO:0070911 | global genome nucleotide-excision repair(GO:0070911) |
| 0.9 | 57.7 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 7.7 | 54.1 | GO:1902963 | regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) |
| 3.8 | 48.9 | GO:2000781 | positive regulation of double-strand break repair(GO:2000781) |
| 2.2 | 44.7 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 4.3 | 39.0 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
| 2.9 | 37.7 | GO:0021769 | orbitofrontal cortex development(GO:0021769) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 19.5 | 116.8 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.4 | 68.3 | GO:0000776 | kinetochore(GO:0000776) |
| 10.8 | 54.1 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 1.0 | 50.9 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 4.5 | 44.7 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.3 | 41.4 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 4.9 | 39.5 | GO:0098575 | lumenal side of lysosomal membrane(GO:0098575) |
| 0.1 | 39.2 | GO:0005925 | focal adhesion(GO:0005925) |
| 1.9 | 37.7 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 3.3 | 33.0 | GO:0000439 | core TFIIH complex(GO:0000439) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 127.5 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 3.7 | 81.1 | GO:0036442 | hydrogen-exporting ATPase activity(GO:0036442) |
| 0.2 | 76.1 | GO:0015631 | tubulin binding(GO:0015631) |
| 3.9 | 54.1 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 5.0 | 44.7 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
| 0.9 | 42.5 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 6.9 | 41.3 | GO:0008309 | double-stranded DNA exodeoxyribonuclease activity(GO:0008309) |
| 2.9 | 40.3 | GO:0031386 | protein tag(GO:0031386) |
| 0.2 | 39.5 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 6.4 | 38.5 | GO:0004308 | exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.0 | 120.9 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.8 | 100.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 5.1 | 96.7 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 1.0 | 66.8 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.2 | 48.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.9 | 44.8 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.5 | 38.1 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.4 | 35.4 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.4 | 32.0 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.2 | 18.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 151.4 | REACTOME TRANS GOLGI NETWORK VESICLE BUDDING | Genes involved in trans-Golgi Network Vesicle Budding |
| 4.0 | 111.2 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 2.9 | 104.4 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.4 | 65.1 | REACTOME MRNA PROCESSING | Genes involved in mRNA Processing |
| 1.2 | 60.2 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.2 | 55.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 2.3 | 45.7 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 1.9 | 44.7 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 1.1 | 37.6 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.3 | 36.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |