ISMARA results: TGIF1

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for TGIF1

Z-value: 1.08

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Transcription factors associated with TGIF1

Gene Symbol	Gene ID	Gene Info
TGIF1 Ensembl NCBI GeneCards UniProt	ENSG00000177426.22	TGIF1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TGIF1	hg38_v1_chr18_+_3451647_3451724	-0.71	4.5e-35	Click!

Activity profile of TGIF1 motif

Sorted Z-values of TGIF1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TGIF1

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr18_+_56651335 Show fit	23.11	ENST00000589935.1 ENST00000254442.8 ENST00000357574.7	WDR7 Ensembl NCBI GeneCards UniProt Show fit	WD repeat domain 7
chr4_+_127965429 Show fit	22.85	ENST00000513371.1 ENST00000611882.1	ABHD18 Ensembl NCBI GeneCards UniProt Show fit	abhydrolase domain containing 18
chr18_+_56651385 Show fit	21.96	ENST00000615645.4	WDR7 Ensembl NCBI GeneCards UniProt Show fit	WD repeat domain 7
chr11_-_111910830 Show fit	18.89	ENST00000526167.5 ENST00000651650.1	CRYAB Ensembl NCBI GeneCards UniProt Show fit	crystallin alpha B
chr11_-_111910888 Show fit	18.86	ENST00000525823.1 ENST00000528961.6	CRYAB Ensembl NCBI GeneCards UniProt Show fit	crystallin alpha B
chr14_+_99684283 Show fit	16.85	ENST00000261835.8	CYP46A1 Ensembl NCBI GeneCards UniProt Show fit	cytochrome P450 family 46 subfamily A member 1
chr11_-_111923722 Show fit	16.64	ENST00000527950.5	CRYAB Ensembl NCBI GeneCards UniProt Show fit	crystallin alpha B
chr1_-_11848345 Show fit	16.33	ENST00000376476.1	NPPA Ensembl NCBI GeneCards UniProt Show fit	natriuretic peptide A
chr2_-_71227055 Show fit	15.38	ENST00000244221.9	PAIP2B Ensembl NCBI GeneCards UniProt Show fit	poly(A) binding protein interacting protein 2B
chr1_-_149917826 Show fit	14.41	ENST00000369145.1 ENST00000369146.8	SV2A Ensembl NCBI GeneCards UniProt Show fit	synaptic vesicle glycoprotein 2A

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.2	54.4	GO:0007021	tubulin complex assembly(GO:0007021)
0.1	41.0	GO:0002244	hematopoietic progenitor cell differentiation(GO:0002244)
5.7	28.4	GO:1901628	positive regulation of postsynaptic membrane organization(GO:1901628)
4.7	28.4	GO:1902261	positive regulation of delayed rectifier potassium channel activity(GO:1902261)
2.6	23.8	GO:2000124	regulation of endocannabinoid signaling pathway(GO:2000124)
0.6	23.7	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
1.3	22.8	GO:0090361	platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.1	20.7	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.1	18.2	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
5.8	17.5	GO:0046878	positive regulation of saliva secretion(GO:0046878)

Showing 1 to 10 of 218 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.4	54.4	GO:0097512	cardiac myofibril(GO:0097512)
0.7	28.4	GO:0042629	mast cell granule(GO:0042629)
0.2	28.3	GO:0030426	growth cone(GO:0030426)
0.2	26.7	GO:0005905	clathrin-coated pit(GO:0005905)
0.1	25.9	GO:0019898	extrinsic component of membrane(GO:0019898)
0.5	25.8	GO:0031430	M band(GO:0031430)
0.2	25.8	GO:0008021	synaptic vesicle(GO:0008021)
0.2	22.4	GO:0005901	caveola(GO:0005901)
0.5	22.1	GO:0097542	ciliary tip(GO:0097542)
0.3	19.9	GO:0048786	presynaptic active zone(GO:0048786)

Showing 1 to 10 of 107 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	51.8	GO:0005212	structural constituent of eye lens(GO:0005212)
1.0	39.7	GO:0005184	neuropeptide hormone activity(GO:0005184)
0.1	27.3	GO:0008017	microtubule binding(GO:0008017)
1.7	23.8	GO:0061578	Lys63-specific deubiquitinase activity(GO:0061578)
1.6	23.8	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.4	19.7	GO:0030507	spectrin binding(GO:0030507)
0.8	18.2	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.3	17.4	GO:0030552	cAMP binding(GO:0030552)
0.5	16.9	GO:0008395	steroid hydroxylase activity(GO:0008395)
0.3	16.6	GO:0050699	WW domain binding(GO:0050699)

Showing 1 to 10 of 173 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	34.7	PID AP1 PATHWAY	AP-1 transcription factor network
0.5	25.8	ST GAQ PATHWAY	G alpha q Pathway
0.1	18.6	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4	17.3	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.3	17.3	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.2	15.7	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.4	14.9	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.5	14.7	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.4	14.4	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.4	13.8	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events

Showing 1 to 10 of 46 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	34.6	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.9	31.3	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.4	20.0	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
1.4	16.9	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1	16.9	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.4	15.8	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
1.2	15.4	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.6	13.7	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
1.1	11.8	REACTOME OPSINS	Genes involved in Opsins
0.4	11.6	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling

Showing 1 to 10 of 74 entries

Results for TGIF1

Z-value: 1.08

Motif logo

Transcription factors associated with TGIF1

Activity-expression correlation:

Activity profile of TGIF1 motif

Sorted Z-values of TGIF1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TGIF1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: