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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for THRA_RXRB
Z-value: 1.04
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Transcription factors associated with THRA_RXRB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| THRA | hg38_v1_chr17_+_40062810_40062901 | -0.40 | 1.3e-09 | Click! |
| RXRB | hg38_v1_chr6_-_33200614_33200680 | -0.01 | 9.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of THRA_RXRB
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 158.9 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 0.4 | 65.8 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 5.6 | 50.6 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 2.6 | 20.8 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 0.9 | 20.0 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.1 | 19.2 | GO:0002576 | platelet degranulation(GO:0002576) |
| 0.7 | 16.5 | GO:0044130 | negative regulation of growth of symbiont in host(GO:0044130) |
| 0.0 | 15.6 | GO:0002250 | adaptive immune response(GO:0002250) |
| 2.1 | 14.5 | GO:1901315 | negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915) |
| 1.2 | 10.4 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 76.7 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 58.8 | GO:0005615 | extracellular space(GO:0005615) |
| 16.9 | 50.6 | GO:0071750 | dimeric IgA immunoglobulin complex(GO:0071750) secretory dimeric IgA immunoglobulin complex(GO:0071752) |
| 0.4 | 26.9 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 22.2 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 20.8 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.0 | 13.5 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 12.7 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.5 | 11.8 | GO:0001891 | phagocytic cup(GO:0001891) |
| 1.7 | 10.4 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 151.4 | GO:0003823 | antigen binding(GO:0003823) |
| 2.1 | 127.4 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 2.6 | 20.8 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 1.6 | 18.0 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
| 0.1 | 15.3 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.3 | 13.9 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.1 | 12.2 | GO:0008565 | protein transporter activity(GO:0008565) |
| 1.0 | 10.0 | GO:0050692 | DBD domain binding(GO:0050692) |
| 1.0 | 8.9 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.0 | 8.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 30.9 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.2 | 16.5 | PID GMCSF PATHWAY | GMCSF-mediated signaling events |
| 0.2 | 12.4 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.2 | 9.8 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 8.4 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 8.0 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 8.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 6.6 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.3 | 5.8 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 3.8 | PID MYC PATHWAY | C-MYC pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 20.3 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.2 | 19.6 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 14.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 11.0 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 8.8 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.2 | 8.0 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.1 | 7.3 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 5.8 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.4 | 4.8 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.4 | 4.8 | REACTOME PROSTANOID LIGAND RECEPTORS | Genes involved in Prostanoid ligand receptors |