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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for THRB

Z-value: 0.62

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Transcription factors associated with THRB

Gene Symbol Gene ID Gene Info
THRB
ENSG00000151090.20 THRB

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
THRBhg38_v1_chr3_-_24494842_24494866,
hg38_v1_chr3_-_24165548_24165595,
hg38_v1_chr3_-_24494875_24494882		-0.212.2e-03Click!

Activity profile of THRB motif

Sorted Z-values of THRB motif

Network of associatons between targets according to the STRING database.

First level regulatory network of THRB

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr12_-_21657792 16.06 ENST00000396076.5
LDHB
lactate dehydrogenase B
chr12_-_21657831 15.95 ENST00000450584.5
ENST00000350669.5
ENST00000673047.2
LDHB
lactate dehydrogenase B
chr13_-_23433735 13.96 ENST00000423156.2
ENST00000683210.1
ENST00000682775.1
ENST00000684497.1
ENST00000682944.1
ENST00000683489.1
ENST00000684385.1
ENST00000683680.1
SACS
sacsin molecular chaperone
chr13_-_23433676 13.91 ENST00000682547.1
ENST00000455470.6
ENST00000382292.9
SACS
sacsin molecular chaperone
chr10_+_60778331 12.51 ENST00000519078.6
ENST00000316629.8
ENST00000395284.8
CDK1
cyclin dependent kinase 1
chr10_+_60778490 11.97 ENST00000448257.6
ENST00000614696.4
CDK1
cyclin dependent kinase 1
chr11_-_64246907 8.57 ENST00000309318.8
PPP1R14B
protein phosphatase 1 regulatory inhibitor subunit 14B
chr11_+_73787853 8.43 ENST00000310614.12
ENST00000497094.6
ENST00000411840.6
ENST00000535277.5
ENST00000398483.7
ENST00000542303.5
MRPL48
mitochondrial ribosomal protein L48
chr6_-_99394164 7.90 ENST00000254759.8
COQ3
coenzyme Q3, methyltransferase
chr10_+_58385395 7.77 ENST00000487519.6
ENST00000373895.7
TFAM
transcription factor A, mitochondrial
chr2_-_9423340 7.08 ENST00000484735.5
ENST00000456913.6
ITGB1BP1
integrin subunit beta 1 binding protein 1
chr8_-_123025627 6.85 ENST00000519018.5
DERL1
derlin 1
chr8_-_130016414 6.19 ENST00000401979.6
ENST00000517654.5
ENST00000522361.1
ENST00000518167.5
CYRIB
CYFIP related Rac1 interactor B
chr16_-_69334871 5.85 ENST00000562949.1
ENSG00000272617.3
novel protein, COG8-PDF readthrough
chr8_-_130016622 5.61 ENST00000518283.5
ENST00000519110.5
CYRIB
CYFIP related Rac1 interactor B
chr20_+_408030 5.50 ENST00000640614.1
ENST00000475269.5
RBCK1
RANBP2-type and C3HC4-type zinc finger containing 1
chr8_-_99893697 4.94 ENST00000518171.5
ENST00000520468.7
COX6C
cytochrome c oxidase subunit 6C
chr2_-_9423190 4.68 ENST00000497105.1
ENST00000360635.7
ENST00000359712.7
ITGB1BP1
integrin subunit beta 1 binding protein 1
chr7_+_103297425 4.00 ENST00000428154.5
ENST00000249269.9
PMPCB
peptidase, mitochondrial processing subunit beta
chrX_+_102599168 3.94 ENST00000246174.6
ARMCX5
armadillo repeat containing X-linked 5
chr8_-_99893622 3.61 ENST00000520271.5
ENST00000522940.5
ENST00000523016.1
ENST00000517682.6
ENST00000297564.6
COX6C
cytochrome c oxidase subunit 6C
chr8_-_99893135 3.15 ENST00000524245.5
COX6C
cytochrome c oxidase subunit 6C
chr22_+_19950896 3.11 ENST00000412786.5
COMT
catechol-O-methyltransferase
chr1_-_160647287 2.85 ENST00000235739.6
SLAMF1
signaling lymphocytic activation molecule family member 1
chr11_-_47378391 2.85 ENST00000227163.8
SPI1
Spi-1 proto-oncogene
chr11_-_47378494 2.68 ENST00000533030.1
SPI1
Spi-1 proto-oncogene
chr19_+_54573781 2.59 ENST00000391738.8
ENST00000251376.7
ENST00000391737.3
ENST00000629481.1
LILRA2
leukocyte immunoglobulin like receptor A2
chr7_+_107580454 2.52 ENST00000379117.6
ENST00000473124.1
BCAP29
B cell receptor associated protein 29
chr11_-_47378527 1.38 ENST00000378538.8
SPI1
Spi-1 proto-oncogene
chr16_+_8642375 1.19 ENST00000562973.1
METTL22
methyltransferase like 22
chr8_+_28316979 0.94 ENST00000518479.5
PNOC
prepronociceptin
chr9_-_136373613 0.73 ENST00000641290.1
ENST00000371732.10
ENST00000371734.7
CARD9
caspase recruitment domain family member 9
chr20_+_408147 0.67 ENST00000441733.5
ENST00000353660.7
RBCK1
RANBP2-type and C3HC4-type zinc finger containing 1
chr20_+_38805686 0.31 ENST00000299824.6
ENST00000373331.2
PPP1R16B
protein phosphatase 1 regulatory subunit 16B
chr22_-_30560759 0.21 ENST00000437282.5
ENST00000447224.5
ENST00000427899.5
ENST00000406955.5
ENST00000452827.5
GAL3ST1
galactose-3-O-sulfotransferase 1
chr17_+_7630094 0.19 ENST00000441599.6
ENST00000380450.9
ENST00000416273.7
ENST00000575903.5
ENST00000571153.5
ENST00000575618.5
ENST00000576152.1
ENST00000576830.5
SHBG
sex hormone binding globulin
chr7_-_38354517 0.13 ENST00000390345.2
TRGV4
T cell receptor gamma variable 4
chr17_+_1742836 0.04 ENST00000324015.7
ENST00000450523.6
ENST00000453723.5
ENST00000453066.6
ENST00000382061.5
SERPINF2
serpin family F member 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 24.5 GO:0090166 regulation of Schwann cell differentiation(GO:0014038) Golgi disassembly(GO:0090166)
2.6 7.8 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
2.4 11.8 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
1.9 32.0 GO:0006089 lactate metabolic process(GO:0006089)
1.5 27.9 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
1.4 6.9 GO:0044027 hypermethylation of CpG island(GO:0044027)
1.1 6.8 GO:0030581 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.9 2.8 GO:0035744 T-helper 1 cell cytokine production(GO:0035744)
0.7 6.2 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.6 11.7 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.5 3.1 GO:0016036 cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) positive regulation of homocysteine metabolic process(GO:0050668)
0.5 2.5 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.4 7.9 GO:0010566 ubiquinone biosynthetic process(GO:0006744) regulation of ketone biosynthetic process(GO:0010566) quinone biosynthetic process(GO:1901663)
0.3 4.0 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.1 8.4 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 0.3 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.1 0.7 GO:0032494 response to peptidoglycan(GO:0032494)
0.0 0.2 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 24.5 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
2.8 27.9 GO:0070852 cell body fiber(GO:0070852)
1.7 6.8 GO:0036502 Derlin-1-VIMP complex(GO:0036502)
1.0 6.2 GO:0071797 LUBAC complex(GO:0071797)
0.3 4.0 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.2 8.4 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 7.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 32.0 GO:0043209 myelin sheath(GO:0043209)
0.0 11.8 GO:0001726 ruffle(GO:0001726)
0.0 13.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 2.8 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 3.1 GO:0043197 dendritic spine(GO:0043197)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 32.0 GO:0004459 lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459)
2.6 7.9 GO:0008169 C-methyltransferase activity(GO:0008169)
1.9 7.8 GO:0070363 mitochondrial light strand promoter sense binding(GO:0070363)
1.1 24.5 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
1.0 27.9 GO:0070628 proteasome binding(GO:0070628)
0.6 6.9 GO:0051525 NFAT protein binding(GO:0051525)
0.5 6.8 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.5 11.8 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.4 11.7 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 3.1 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.2 8.6 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 0.9 GO:0001515 opioid peptide activity(GO:0001515)
0.1 0.7 GO:0050700 CARD domain binding(GO:0050700)
0.0 6.2 GO:0043130 ubiquitin binding(GO:0043130)
0.0 4.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.2 GO:0005497 androgen binding(GO:0005497)
0.0 0.2 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 5.4 GO:0003823 antigen binding(GO:0003823)
0.0 1.2 GO:0016278 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 24.5 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 8.6 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 6.9 PID IL4 2PATHWAY IL4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 24.5 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.9 31.1 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.1 11.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 4.6 REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
0.0 3.1 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.0 6.2 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.7 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway