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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for TLX1_NFIC
Z-value: 1.92
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Transcription factors associated with TLX1_NFIC
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFIC | hg38_v1_chr19_+_3366549_3366621 | 0.42 | 6.6e-11 | Click! |
| TLX1 | hg38_v1_chr10_+_101131284_101131321 | 0.24 | 4.6e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TLX1_NFIC
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 121.2 | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919) |
| 20.9 | 104.6 | GO:1902998 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 5.3 | 89.5 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 13.6 | 67.8 | GO:1904209 | regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
| 13.3 | 53.3 | GO:1902228 | positive regulation of odontogenesis of dentin-containing tooth(GO:0042488) mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 1.7 | 51.5 | GO:0031639 | plasminogen activation(GO:0031639) |
| 2.4 | 49.5 | GO:0032060 | bleb assembly(GO:0032060) |
| 4.1 | 49.4 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 11.7 | 46.9 | GO:1903631 | regulation of calcium-dependent ATPase activity(GO:1903610) negative regulation of calcium-dependent ATPase activity(GO:1903611) regulation of dUTP diphosphatase activity(GO:1903627) positive regulation of dUTP diphosphatase activity(GO:1903629) negative regulation of aminoacyl-tRNA ligase activity(GO:1903631) regulation of leucine-tRNA ligase activity(GO:1903633) negative regulation of leucine-tRNA ligase activity(GO:1903634) |
| 2.5 | 45.5 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.6 | 129.5 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 5.6 | 89.5 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.1 | 70.6 | GO:0045177 | apical part of cell(GO:0045177) |
| 11.3 | 67.8 | GO:0033269 | internode region of axon(GO:0033269) |
| 8.9 | 53.3 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.1 | 50.7 | GO:0030424 | axon(GO:0030424) |
| 0.1 | 50.2 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.5 | 49.7 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.4 | 49.4 | GO:0005604 | basement membrane(GO:0005604) |
| 2.6 | 43.7 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 33.2 | 132.8 | GO:0005163 | nerve growth factor receptor binding(GO:0005163) |
| 4.5 | 104.3 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 3.3 | 99.5 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 5.6 | 67.8 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 10.7 | 53.3 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.4 | 51.1 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.4 | 48.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 11.7 | 46.9 | GO:0004341 | gluconolactonase activity(GO:0004341) |
| 10.9 | 43.7 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
| 9.1 | 36.6 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 90.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.2 | 61.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 1.2 | 58.4 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 1.3 | 57.7 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.3 | 57.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 55.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 1.3 | 50.8 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.5 | 37.5 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.3 | 33.9 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.9 | 33.4 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 106.1 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 1.5 | 53.6 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.3 | 40.2 | REACTOME SIGNALING BY PDGF | Genes involved in Signaling by PDGF |
| 0.3 | 29.7 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.4 | 28.9 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 1.1 | 27.0 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.5 | 25.1 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.9 | 21.7 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.2 | 19.3 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.9 | 17.4 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |