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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for TLX2
Z-value: 0.87
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Transcription factors associated with TLX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TLX2 | hg38_v1_chr2_+_74514442_74514494, hg38_v1_chr2_+_74513441_74513559 | 0.31 | 4.1e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TLX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 13.5 | GO:1900138 | negative regulation of phospholipase A2 activity(GO:1900138) |
| 2.2 | 13.0 | GO:0051138 | positive regulation of NK T cell differentiation(GO:0051138) |
| 2.9 | 11.5 | GO:0031117 | positive regulation of microtubule depolymerization(GO:0031117) |
| 1.4 | 9.8 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 0.1 | 9.4 | GO:0061028 | establishment of endothelial barrier(GO:0061028) |
| 0.7 | 9.0 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.1 | 9.0 | GO:0030330 | DNA damage response, signal transduction by p53 class mediator(GO:0030330) |
| 0.1 | 8.9 | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502) |
| 2.9 | 8.8 | GO:0002884 | negative regulation of hypersensitivity(GO:0002884) |
| 0.2 | 7.6 | GO:0014072 | response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.9 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 13.9 | GO:0009986 | cell surface(GO:0009986) |
| 0.1 | 13.7 | GO:0030426 | growth cone(GO:0030426) |
| 0.1 | 13.0 | GO:0016605 | PML body(GO:0016605) |
| 1.2 | 9.4 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.7 | 9.0 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.1 | 9.0 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.4 | 8.8 | GO:0001931 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.1 | 8.5 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.4 | 8.4 | GO:0016461 | unconventional myosin complex(GO:0016461) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 24.6 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.7 | 19.7 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.0 | 17.6 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.1 | 15.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.1 | 13.4 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.1 | 11.2 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 3.6 | 10.7 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 0.3 | 9.4 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.0 | 9.3 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 2.8 | 8.4 | GO:0060001 | minus-end directed microfilament motor activity(GO:0060001) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 45.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 13.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 10.9 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.2 | 10.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.3 | 9.7 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 9.6 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.3 | 7.8 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.1 | 7.6 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 5.7 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.3 | 4.3 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.3 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.2 | 9.7 | REACTOME G PROTEIN ACTIVATION | Genes involved in G-protein activation |
| 0.3 | 9.0 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.4 | 8.4 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.1 | 7.1 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 6.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 5.8 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 5.8 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.2 | 5.7 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.1 | 5.4 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |