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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for TP53
Z-value: 0.97
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Transcription factors associated with TP53
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TP53 | hg38_v1_chr17_-_7687427_7687538 | 0.39 | 3.3e-09 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TP53
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 25.7 | GO:0034314 | Arp2/3 complex-mediated actin nucleation(GO:0034314) |
| 2.6 | 23.0 | GO:0060574 | intestinal epithelial cell maturation(GO:0060574) |
| 0.1 | 22.0 | GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling(GO:0014066) |
| 1.4 | 21.5 | GO:0070986 | left/right axis specification(GO:0070986) |
| 1.6 | 19.4 | GO:0060056 | mammary gland involution(GO:0060056) |
| 4.7 | 18.9 | GO:0016334 | morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247) |
| 1.5 | 18.9 | GO:0071550 | death-inducing signaling complex assembly(GO:0071550) |
| 0.7 | 18.9 | GO:0032802 | low-density lipoprotein particle receptor catabolic process(GO:0032802) |
| 0.1 | 18.9 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
| 6.1 | 18.3 | GO:0001732 | formation of cytoplasmic translation initiation complex(GO:0001732) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.5 | 32.4 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 0.1 | 28.7 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 8.6 | 25.7 | GO:0036284 | tubulobulbar complex(GO:0036284) |
| 0.9 | 21.5 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 21.4 | GO:0005925 | focal adhesion(GO:0005925) |
| 3.8 | 18.9 | GO:0042643 | actomyosin, actin portion(GO:0042643) |
| 0.9 | 18.9 | GO:0036020 | endolysosome membrane(GO:0036020) |
| 1.8 | 18.3 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 2.8 | 17.1 | GO:1990357 | terminal web(GO:1990357) |
| 0.2 | 16.5 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 42.8 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 4.6 | 23.0 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
| 0.1 | 22.9 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.9 | 21.4 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 3.2 | 19.4 | GO:0043120 | tumor necrosis factor binding(GO:0043120) |
| 0.5 | 19.1 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 6.1 | 18.3 | GO:0098808 | mRNA cap binding(GO:0098808) |
| 3.0 | 17.9 | GO:0016900 | oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057) |
| 1.8 | 16.5 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.2 | 15.2 | GO:0070063 | RNA polymerase binding(GO:0070063) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 26.1 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.3 | 25.6 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 1.6 | 23.0 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.2 | 19.5 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.7 | 18.9 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.5 | 18.9 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 18.7 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.3 | 17.9 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 17.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.5 | 15.0 | PID ALK1 PATHWAY | ALK1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 30.6 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.7 | 24.0 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.3 | 22.9 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.2 | 18.5 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.9 | 17.9 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.8 | 16.3 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.7 | 16.0 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.2 | 15.2 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.5 | 14.7 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |
| 0.2 | 13.9 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |